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Posted: Sat Oct 27, 2007 7:16 pm Post subject: Progesterone--Mice
Hi all
I’m happy to report that I think it’s finally time to start a progesterone thread.
I know the confidence level in mouse research (mine included) ranges from 0 to –0, but I wanted to initiate a timeline of the development of progesterone starting with the early research in mice. And, the mouse trials are off and running…..
Here’s some postive info (for the mice at least) and the studies have been on the traditional (EAE) and non-traditional (not auto-immune) animal models.
Clinically, PROG produced a moderate delay of disease onset and reduced the clinical scores. Thus, PROG attenuated disease severity, and reduced the inflammatory response and the occurrence of demyelination in the spinal cord during the acute phase of EAE
I found the second study (from Ectrims 2007) even more interesting because it appears to be based on a “not auto-immune” perspective of MS. It’s based on a mouse model that takes into account the research findings of Prineas and Barnett (oligodendrocytes die first).
Barnett and Prineas (Ann Neurol 2004, 55:458) described extensive oligodendrocyte apoptosis and microglia activation in myelinated tissues of young MS patients with relapsing and remitting MS revealing no or few invading lymphocytes.
These data clearly indicate that both sex hormones are required to fully prevent cuprizone-induced demyelination in the CC. We conclude that P and E supplementation of MS patients may represent a valuable clinical tool.
Guys—note that this was a study in male mice and both progesterone and estrogen were found to “represent” a potentially valuable clinical tool.
Let’s hope clinical trials don’t take forever…I of course assume it will make it that far. The countdown begins.....
Since the Phase II Clinical Trial of progesterone in traumatic brain injury was positive I do have some confidence the mice research might actually translate to humans.
RESULTS: Progesterone given prior to EAE induction attenuated the clinical scores of the disease, slightly delayed disease onset and decreased demyelination foci,
In turn, combined E(2) plus progesterone therapy more effectively prevented neurological deficits, fully restored LFB staining, MBP and PLP immunoreactivity and avoided inflammatory cell infiltration.
On the neuronal side, steroid biotherapy increased brain-derived neurotrophic factor (BDNF) mRNA.
CONCLUSION:.... Therefore, sex steroids should be considered as potential novel therapeutic strategies for MS.
I think the "news" here is that someone is at least considering both progesterone and estrogen.
I added progesterone 50mg about 2 weeks ago and 25mg DHEA about a week ago as my hormone levels are all out of syn (low progesterone and luteinizing hormone). I have continued to enjoy considerable improvements in all of my deficits which began when increasing the herbs so there has certainly been no negative impact. I cannot determine any immediate improvement on taking them such as I noticed when I increased the salvia and scutelleria. _________________ 1st traceable symptoms Jan 01, last edss by doctor 6.5. Feeling better on ginkgo, salvia, capsaicin, curcumin, scutellaria. Interested in other vascular strengthening herbs; pycnogenol, butcher's broom, horsechestnut, centenella, hersperidin
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