Omega 3 and 6 research

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1212

More supporting evidence that PUFAs could be helpful for MS sufferers...

Polyunsaturated Fatty Acid supplementation stimulates differentiation of oligodendroglia cells.

Dev Neurosci. 2006;28(3):196-208.
van Meeteren ME, Baron W, Beermann C, Dijkstra CD, van Tol EA.
Biomedical Research Department, Numico Research B.V., Wageningen, The Netherlands.

Dietary polyunsaturated fatty acids (PUFAs) have been postulated as alternative supportive treatment for multiple sclerosis, since they may promote myelin repair. We set out to study the effect of supplementation with n-3 and n-6 PUFAs on OLN-93 oligodendroglia and rat primary oligodendrocyte differentiation in vitro.

It appeared that OLN-93 cells actively incorporate and metabolise the supplemented PUFAs in their cell membrane. The effect of PUFAs on OLN-93 differentiation was further assessed by morphological and Western blot evaluation of markers of oligodendroglia differentiation: 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), zonula occludens-1 (ZO-1) and myelin-associated glycoprotein (MAG). Supplementation of the OLN-93 cells with n-3 and n-6 PUFAs increased the degree of differentiation determined by morphological analysis. Moreover, CNP protein expression was significantly increased by gamma-linolenic acid (GLA, 18:3n-6) supplementation. In accordance with the OLN-93 results, studies with rat primary oligodendrocytes, a more advanced model of cell differentiation, showed GLA supplementation to promote oligodendrocyte differentiation. Following GLA supplementation, increased numbers of proteolipid protein (PLP)-positive oligodendrocytes and increased myelin sheet formation was observed during differentiation of primary oligodendrocytes. Moreover, increased CNP, and enhanced PLP and myelin basic protein expression were found after GLA administration.

These studies provide support for the dietary supplementation of specific PUFAs to support oligodendrocyte differentiation and function.

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carolew · Posted: Fri Aug 11, 2006 9:26 am Post subject:

I just started taking Omega3 capsules. Is there a trick to avoid the burping that tastes like fish???? I take it in the morning with my hot coco and I think it melts the capsule too fast. I will try with just cold water next time. They should make these mint flavored or something.... Laughing

verminsquibble · Posted: Fri Aug 11, 2006 9:35 am Post subject:

You may want to try storing the capusles in the refrigerator. A dietician I saw while in the hospital for a relapse suggested it to me. It does the trick for me. And I think avoiding any hot liquids is a good idea too.

VS

jimmylegs · Family Elder Joined: Mar 12, 2006 Posts: 2117

when you are finished the fishy ones you could consider a veggie omega blend containing things like flax seed and evening primrose oils. i think borage is the other one usually seen in such blends. but your vitamin d would have to come from elsewhere of course!

NHE · Volunteer Moderator Joined: Nov 21, 2004 Posts: 776

carolew · Posted: Sat Aug 12, 2006 9:12 am Post subject:

Thanks every one. Those are really helpful hints. Will try those today and the bottle is going in the fridge right now. Wink

Melody · Posted: Thu Aug 31, 2006 4:59 am Post subject:

Who ever said leave it in the fridge hit the nail on the head. Also did you know if you don't refrigerate them it can go rancid in a matter of days depending on the house temperature. No hot liquids either it dissolves it in your mouth or throat. Once rancid it is a free radical that causes damage to your system.Do yourself a favor store all fat soluble vitamins in the fridge. No exceptions. All water soluble needs to be in a dry dark place like a cupboard and not the one over the stove to much steam. Fresh is always best in supplements. IMO
_________________
John was diagnosed Jan 2005. On lipitor 20mg .On Copaxone since July 4,2005. Vitamin D3 2000iu-4000iu (depending on sunshine months)June 10 2005(RX: Very Happy

r. O'Connor) Omega 3 as well Turmeric since April 2005. Q10 60mg. 1500mg liquid Glucosamine Nov 2005.

Kt · Newbie Joined: Jul 20, 2006 Posts: 9 Location: Bath, UK

Melody those are some interesting points you wrote about. I didn't realise that Fish Oil capsules go rancid and would explain why my new pack of Krill Oil smelt really bad when I opened it. Embarassed

It had been sitting outside my flat for 3days during the hot weather! Putting it in the fridge didn't help either so I just learnt to contain my gagging!! I am just about to start on Hemp Seed Oil Confused

(recommended to me by my homeopath).

Kt

jim4030 · Getting to Know You... Joined: Oct 05, 2006 Posts: 18

why don't you try it with honey?? i use to take each every morning and add some honey with it all around... mmmmmm
try it and you will see that you will not get the bad taste that goe s up. Embarassed