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Experience Project.
Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review)
M. S. Seelig
Stress intensifies release of catecholamines and corticosteroids that increase survival of normal animals when their lives are threatened. When magnesium (Mg) deficiency exists, stress paradoxically increases risk of cardiovascular damage including hypertension, cerebrovascular and coronary constriction and occlusion, arrhythmias and sudden cardiac death (SCD). In affluent societies, severe dietary Mg deficiency is uncommon, but dietary imbalances such as high intakes of fat and/or calcium (Ca) can intensify Mg inadequacy, especially under conditions of stress. Adrenergic stimulation of lipolysis can intensify its deficiency by complexing Mg with liberated fatty acids (FA), A low Mg/Ca ratio increases release of catecholamines, which lowers tissue (i.e. myocardial) Mg levels. It also favors excess release or formation of factors (derived both from FA metabolism and the endothelium), that are vasoconstrictive and platelet aggregating; a high Ca/Mg ratio also directly favors blood coagulation, which is also favored by excess fat and its mobilization during adrenergic lipolysis. Auto-oxidation of catecholamines yields free radicals, which explains the enhancement of the protective effect of Mg by anti-oxidant nutrients against cardiac damage caused by beta-catecholamines. Thus, stress, whether physical (i.e. exertion, heat, cold, trauma--accidental or surgical, burns), or emotional (i.e. pain, anxiety, excitement or depression) and dyspnea as in asthma increases need for Mg. Genetic differences in Mg utilization may account for differences in vulnerability to Mg deficiency and differences in body responses to stress.
Noise-induced hypertension and magnesium in rats: relationship to microcirculation and calcium
B. M. Altura, B. T. Altura, A. Gebrewold, H. Ising and T. Gunther
It has been demonstrated that audiogenic stress (AS) can induce elevation of arterial blood pressure (ABP) in animals and humans and that noise-induced hearing loss may be associated with alterations in Mg metabolism. Experiments were designed to determine whether 1) there is a causal relationship among environmental noise stress, serum and vascular tissue (aortas and portal veins) Mg contents, and development of hypertension and 2) such noise-induced hypertension has a microcirculatory basis and what the mechanism may be. Rats maintained on normal Mg-containing diets for 12 wk (plasma [Mg] = 0.96 +/- 0.02 mM) and subjected to AS (85 dB(A), 12 h/day for 8 wk; 95 dB(A), 16 h/day for 4 wk) demonstrated significant elevation in systolic and diastolic ABP; plasma [Mg] showed a 15% deficit, whereas aortic and portal vein muscle exhibited slight reductions in Mg content and elevation in Ca. Moderate and more severely Mg-deficient animals not subjected to AS also exhibited significant elevations in systolic and diastolic ABP; vascular tissue Mg content decreased, whereas Ca content rose. Animals subjected to combined Mg deficiency and AS for 12 wk exhibited the greatest deficits in plasma and vascular muscle Mg and the greatest elevations in systolic and diastolic ABP; vascular tissue Ca contents also showed the greatest increases. In situ measurements of mesenteric arterioles, venules, and precapillary sphincters in the various subgroups revealed that the lower the plasma [Mg], the more constricted the microvessels, and the higher the ABP, the lower the plasma [Mg]. Capillary blood flow velocities were decreased in relation to the degree of plasma Mg deficit.(ABSTRACT TRUNCATED AT 250 WORDS)
Joined: Apr 21, 2008 Posts: 216 Location: New Brunswick, Canada
Posted: Wed May 07, 2008 7:26 pm Post subject:
That's a lot of info to digest :p~ On to reading I go! _________________ Dx RRMS March 5, 2008. I achieved my dx in absence of a GP, by being proactive and telling my story. An ENT listened and ordered my MRI, leading to my dx.
Joined: Apr 21, 2008 Posts: 216 Location: New Brunswick, Canada
Posted: Wed May 07, 2008 8:34 pm Post subject:
All good. Course, the crazy pain from this mouth is not good lol.
I figured I could control the stress I'm experiencing somehow with mind control... uh, it's not happening.
Interestingly I read about Klonopin (sp) and it's positive effects treating BMS. I'm calling the neuro tomorrow to ask about this, because wow this is intense.
Sticking with my magnesium increase in the meantime, but this is way out of control that only rest will calm it down a bit. _________________ Dx RRMS March 5, 2008. I achieved my dx in absence of a GP, by being proactive and telling my story. An ENT listened and ordered my MRI, leading to my dx.
ugh sounds so yuck! so it's gotten bad in the evening again i take it.
ya hopefully the klonopin will help with it too. hope you can find some way to relax ... i guess only time will get rid of the house stress huh bummer
Joined: Apr 21, 2008 Posts: 216 Location: New Brunswick, Canada
Posted: Wed May 07, 2008 10:13 pm Post subject:
Well, it's the sale of house plus the fact that 1h of sitting on the floor going through boxes nearly killed me, realizing that I am unable to move myself right now, no car, no idea who I can get to help move... etc. I just need to move LOL.
I haven't seen my parents in a few years, and they're coming at the end of May. That's my 1 saving grace right now.
Oh MY. My friend linked me to a public webcam of 3 kittens in a cage. I've been watching them for a good hour, and I'm beginning to feel better because it takes my mind off the symptoms _________________ Dx RRMS March 5, 2008. I achieved my dx in absence of a GP, by being proactive and telling my story. An ENT listened and ordered my MRI, leading to my dx.
Joined: Apr 21, 2008 Posts: 216 Location: New Brunswick, Canada
Posted: Thu May 08, 2008 1:34 pm Post subject:
Just to add, I thought with MS that since I now knew what I was dealing with, if symptoms reappeared, I could calm myself down and thus calm the symptoms in turn. I guess the burst of complete relief I felt hearing my diagnosis was enough to sway me for the positive back in March... because right now, while I did get a lot of sleep and I am feeling a teeny bit better now, I can tell you that my symptoms are far from returned to that good status.. they're just lurking and ready to flare back up again. _________________ Dx RRMS March 5, 2008. I achieved my dx in absence of a GP, by being proactive and telling my story. An ENT listened and ordered my MRI, leading to my dx.
hey nenu, glad u have a couple of plusses at least!
sorry you're feelin generally crappy still though. that's so lame that you have to deal with pain as part of your ms symptoms. the only pain i've had is not ms-related, but definitely requires rest. i'm also hitting it with zinc - and b100-complex - aiming for improvement! might help more if i actually took my stuff REGULARLY again, yikes.
Joined: Apr 21, 2008 Posts: 216 Location: New Brunswick, Canada
Posted: Thu May 08, 2008 1:55 pm Post subject:
Yeah, it's the nerves... my head feels like it's swimming today lol. I imagine they're going to have me back on steroids tomorrow, but we'll see what my doctor does I guess. _________________ Dx RRMS March 5, 2008. I achieved my dx in absence of a GP, by being proactive and telling my story. An ENT listened and ordered my MRI, leading to my dx.
Joined: Apr 21, 2008 Posts: 216 Location: New Brunswick, Canada
Posted: Thu May 08, 2008 4:21 pm Post subject:
Well I honestly hope I'm not put on as many/as much as before. 6 days on IV was unreal lol. Is it unheard of to go through 6 days/1 month oral to taper off, and then 2 months after the initial IV dose, fall back into the symptoms again?
I start my copaxone finally on Saturday.. perhaps had I began copaxone prior to now, I wouldn't be in such a mess? _________________ Dx RRMS March 5, 2008. I achieved my dx in absence of a GP, by being proactive and telling my story. An ENT listened and ordered my MRI, leading to my dx.
i couldn't tell you nenu! by the time they were ready for me to start rebif, i had been reading enough that i changed my mind and i never got any ms drugs period. at this stage i reckon i'd have to ask for steroids lol!
Joined: Apr 21, 2008 Posts: 216 Location: New Brunswick, Canada
Posted: Fri May 09, 2008 7:42 am Post subject:
Well I saw my GP this morning, and she went over a ton of things with me. She suggested waiting till Tuesday to see if the symptoms clear up, and if they do, no worries. If not, then I'll do the steroid route again. My neurologist wanted me back on them, but I'd rather see if I can avoid them before putting myself through them, because they were not fun _________________ Dx RRMS March 5, 2008. I achieved my dx in absence of a GP, by being proactive and telling my story. An ENT listened and ordered my MRI, leading to my dx.
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