Research presentation movie

Damjan · Newbie Joined: Apr 09, 2005 Posts: 5

Not really an FDA approved (yet), but looks promising... Worth watching, at least was for me... Any comments?

http://www.youtube.com/watch?v=uzw6_cWqdkY

Regards from Slovenia, Europe.

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1138

Good find, this is the research group that I was talking about here:

http://www.thisisms.com/ftopict-1441.html

It sounds like they don't have the money to do a trial, but if they can find a pharma company partner, they could be ready to start human trials in a year.

gwa · Family Elder Joined: Dec 02, 2005 Posts: 679

Fascinating presentation! This is the best discussion as to what is going on with us that I have seen.

gwa

cheerleader · Posted: Tue May 06, 2008 9:05 pm Post subject:

Looks like Dr. Chandy and his team have found a drug development deal with Airmid, but they still need big pharma partnership money...

I'm surprised big pharma isn't all over this, since it can be used in all auto-immune situations. I'd invest Smile

http://www.airmid.com/shk.html#

AC
_________________
Husband diagnosed RRMS March 2007
20 lesions brain/spine
Copaxone, Swank, supplements, laughter

rainer · Family Elder Joined: Jan 18, 2008 Posts: 151

I passed this on to the fast forward group and they say they've been in contact with Dr. Chandy. Hopefully, they hook him up with some $$$.

Damjan · Newbie Joined: Apr 09, 2005 Posts: 5

I have some questions about this movie, maybe worth of discussion:

Are all the cells that use the "red" potassium channel bad? It seemed to me that those are the cells that sustain our life-time immunity (some of them attacking our own body chronically)... Wouldn't blocking those cells (and leaving us with only those ad-hoc T-cells) make us vulnerable to other diseases? It was said that 95% of the cells in lesions are using this potassium channel, but once again - are those all of them? Why did the nature (evolution) "invent" the "red" potassium channel then? Any opinions?

I agree that the presentation is great.

Best regards.

cheerleader · Posted: Wed May 07, 2008 2:31 pm Post subject:

Hi Damjan-
From what I understood, this is a very selective potassium channel blocker. Dr. Chandy was speaking in general terms so that we lay folk could grasp how the process works. Not all "red channels" will be affected. Just the "professional T cells."

Here are the specifics-

The structurally defined sea anemone peptide toxins ShK and BgK potently block the intermediate conductance, Ca2+-activated potassium channel IKCa1, a well recognized therapeutic target present in erythrocytes, human T-lymphocytes, and the colon. The well characterized voltage-gated Kv1.3 channel in human T-lymphocytes is also blocked by both peptides, although ShK has a ~1,000-fold greater affinity for Kv1.3 than IKCa1.

http://www.jbc.org/cgi/content/abstract/274/31/21885

Much easier to understand Dr. Chandy's red and blue pictures Smile

AC
_________________
Husband diagnosed RRMS March 2007
20 lesions brain/spine
Copaxone, Swank, supplements, laughter

gwa · Family Elder Joined: Dec 02, 2005 Posts: 679

It seemed strange to me that Pfizer and AstraZeneca, who Dr. Chandry spent years with going over their compounds, did not step up to become his venture capital partners.

Is it possible that he and his colleagues don't want to turn the research over to a pharma company because they lose control of the project?

Beats me why he would have trouble getting money because this looks like it could be the real deal for curing autoimmune diseases.

gwa

rainer · Family Elder Joined: Jan 18, 2008 Posts: 151

Anyone know if what he refers to as Professional T-Cells is what we often hear as Killer T-Cells?

dignan · Family Elder Joined: Aug 12, 2004 Posts: 1138

GWA, I think your suggestion about control makes sense. I saw something on the Bionomics website (company coming out with their own kv1.3 inhibitor, so take this with a grain or two of salt) that could possibly make some big pharma less interested:

ShK-L5 advantages: High Selectivity to KV1.3
ShK-L5 disadvantages: Polypeptide (Large Molecule), Not orally available, Expensive

Also, this report does make for an interesting read if you want to know where things stood with Kv1.3 research 2 years ago (and who doesn't?!)...
http://www.bionomics.com.au/siteFiles/files/Intersuisse_April_2006_Report.pdf

cheerleader · Posted: Wed May 07, 2008 11:17 pm Post subject:

Dr. Chandy has founded his own company- Airmid. He is founder, director, and on the "drug development committee." I'm sure there are control issues and proprietary ones, as well. My uncle was a developer for a large international chemical corporation, and had to sign over all of his research and patents to his company. He did not receive revenues or royalties on his inventions.

The site states that Airmid is" seeking a committed pharma partner for development of any or all of three autoimmune products:
ORAL OR TOPICAL PSORIASIS DRUG
ORAL MULTIPLE SCLEROSIS DRUG
INJECTABLE MULTIPLE SCLEROSIS DRUG"

I hope they can work out any issues, find a partner, and get going on trials. It would really be a huge loss to everyone if this drug was held up because of money issues.

sigh,
AC
_________________
Husband diagnosed RRMS March 2007
20 lesions brain/spine
Copaxone, Swank, supplements, laughter

gwa · Family Elder Joined: Dec 02, 2005 Posts: 679

gwa · Family Elder Joined: Dec 02, 2005 Posts: 679