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Joined: May 26, 2004 Posts: 1355 Location: London, ON, Canada
Posted: Tue May 06, 2008 2:19 pm Post subject: Bone marrow transplant
Dr. Freedman in Ottawa, continues to monitor his MS bone marrow transplant patients. He is getting some interesting results. Here is the link to the article.
Joined: May 04, 2006 Posts: 3371 Location: Mid-Michigan
Posted: Tue May 06, 2008 2:48 pm Post subject:
Thanks Harry, interesting link!
Now, consider that Revimmune is basically the same process, with the same or better results and doesn't require killing the bone marrow, which creates the immune system....and so doesn't carry nearly the risk over the longer time period necessary for the bone marrow to regenerate and then create the new immune system.
At that point you might consider that eliminating the disease process might not be enough. People who currently have MS have obviously shown to have the necessary predispositions and are obvious candidates to be stricken with MS again in a matter of time.
Whether it will prove out or not I can't say, but after Revimmune treatment JH researchers are using Copaxone, which is thought to work by sending out myelin decoys for the myelin reactive T cells to attack, reducing the likelihood that they will be attacking real myelin.
By using the copaxone on the virgin or naive immune system, the hope is that the experience with the myelin decoys will mature the immune system to respond appropriately in the future. In other words, exposing the naive immune system to a modern version of evolutionary normal conditions.
Bob _________________ Wife diagnosed with MS in Feb. 2006 and is a participant in the Tovaxin IIb clinical trial.
I think the point of the article is that it is not the eradication of the immunesystem (improvements started 2 years after removing the immunesystem), but the introduction of the bonemarrow stem cells.
If this is truely the case then RevImmune will not do the trick.
--Frank _________________ Current regime: Tysabri restarted 05/2008 after LDN, ABX Wheldon Regime for 1 year, interested in T-Cell vaccination, helminth immunomodulation
Joined: May 04, 2006 Posts: 3371 Location: Mid-Michigan
Posted: Thu May 08, 2008 1:43 pm Post subject:
Frank wrote:
I think the point of the article is that it is not the eradication of the immune system (improvements started 2 years after removing the immune system), but the introduction of the bone marrow stem cells.
If this is truly the case then RevImmune will not do the trick.
Hi Frank, thanks for pointing that out. I think you're right, in that they didn't seem to eliminate the immune system, only the bone marrow.
Kind of an interesting experiment but doesn't really reflect on Revimmune at all. What Freedman did in this one (evidently) was eliminate the only the bone marrow and so it took two years for enough of the old immune system to die off and be replaced with healthy T cells and show improvement.
The end result will eventually be the same as with Revimmune, but Revimmune starts eliminating the immune system immediately and starts showing improvements quickly.
Bob _________________ Wife diagnosed with MS in Feb. 2006 and is a participant in the Tovaxin IIb clinical trial.
Joined: Sep 26, 2007 Posts: 133 Location: East Coast USA
Posted: Thu May 08, 2008 9:46 pm Post subject:
Very interesting stuff, I had not heard they were doing that. I had a very close friend and relative who had a bone marrow transplant and I knew how this stuff worked since I was a kid. I am surprised I had not thought of this before. A very scary thing to go through for sure. Hope the results are great for those people.
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