Creatine

NHE · Volunteer Moderator Joined: Nov 21, 2004 Posts: 769

Here's a nice drawing of one...

cheerleader · Posted: Tue Sep 16, 2008 7:49 pm Post subject:

Went back to creatine supplements in the last couple of weeks. Stopping didn't change the spasms. We think the painful spasms were due to excessive heat in LA, and not the creatine.

Jeff does well on 6g. of powder mixed in his morning juice or coffee. The powder doesn't have a taste. It's helping him get thru the afternoon without a nap, and now that the weather is cooler, his spasms and pain are less.
whew,
AC
_________________
Husband diagnosed RRMS March 2007
pursuing endothelial healing
Copaxone, Swank, supplements, laughter

Cojack · Getting to Know You... Joined: Nov 12, 2008 Posts: 23

Hi Cheerleader et al,

I've recently considered taking creatine....found some articles that i interpret as being good for fighting glutamate issues in the brain....anybody have a take on this?

The protective effects of creatine against glutamate cytotoxicity have been demonstrated in neuronal cells and animal models of neurodegenerative diseases. The mechanisms underlying creatine neuroprotection against glutamate-induced cell death are understood poorly. For the first time, we demonstrate a correlation between the protective effect of creatine and the modulation of Ras-mediated redox-dependent signaling pathways, which involve nuclear factor B (NF-B) and reactive oxygen species (ROS). In primary cerebrocortical cultures of mixed neurons and glia, creatine significantly reduced glutamate-induced cell death. The increase in cell survival was accompanied by increased generation of oxygen radicals and decreased levels of farnesylated Ras and IB, an inhibitor of NF-B. Non-farnesylated Ras and ROS-dependent activation of NF-B have been shown to promote neuronal survival. Our data suggest that creatine may enhance survival signaling via activation of the Ras/NF-B system. Possible mechanisms underlying the protective effect of creatine are discussed, including normalization of cellular GTP levels. © 2004 Wiley-Liss, Inc.
ad that creatine