Vitamin D News

NHE · Volunteer Moderator Joined: Nov 21, 2004 Posts: 769

Not MS related but still interesting nonetheless...

Low vitamin D seen more in patient deaths
http://seattlepi.nwsource.com/national/368175_vitamins24.html

Research backs importance of dose of 'sunshine'

Last updated June 23, 2008 9:13 p.m. PT
By Lindsey Tanner, The New York Times

CHICAGO -- New research linking low vitamin D levels with deaths from heart disease and other causes bolsters mounting evidence about the "sunshine" vitamin's role in good health.

Patients with the lowest blood levels of vitamin D were about two times more likely to die from any cause during the next eight years than those with the highest levels, the study found. The link with heart-related deaths was particularly strong in those with low vitamin D levels.

Experts say the results shouldn't be seen as a reason to start popping vitamin D pills or to spend hours in the sun, which is the main source for vitamin D.

For one thing, megadoses of vitamin D pills can be dangerous and skin cancer risks from too much sunshine are well-known. But also, it can't be determined from this type of study whether lack of vitamin D caused the deaths, or whether increasing vitamin D intake would make any difference.

Low vitamin D levels could reflect age, lack of physical activity and other lifestyle factors that also affect health, said American Heart Association spokeswoman Alice Lichtenstein, director of the Cardiovascular Nutrition Laboratory at Tufts University.

Still, she said the study is an important addition to an emerging area of research.

"This is something that should not be ignored," Lichtenstein said.

The study led by Austrian researchers involved 3,258 men and women in southwest Germany. Participants were aged 62 on average, most with heart disease, whose vitamin D levels were checked in weekly blood tests. During roughly eight years of follow-up, 737 died, including 463 from heart-related problems.

According to one of the vitamin tests they used, there were 307 deaths in patients with the lowest levels, versus 103 deaths in those with the highest levels. Counting age, physical activity and other factors, the researchers calculated that deaths from all causes were about twice as common in patients in the lowest-level group.

Results appear in Monday's Archives of Internal Medicine.

The study's lead author, Dr. Harald Dobnig of the Medical University of Graz in Austria, said the results don't prove that low levels of vitamin D are harmful "but the evidence is just becoming overwhelming at this point."

Scientists used to think that the only role of vitamin D was to prevent rickets and strengthen bones, Dobnig said.

"Now we are beginning to realize that there is much more (to) it," he said.

Exactly how low vitamin D levels might contribute to heart problems and deaths from other illnesses is uncertain, although it is has been shown to help regulate the body's disease-fighting immune system, he said.

It has been estimated that at least 50 percent of older adults worldwide have low vitamin D levels, and the problem is also thought to affect substantial numbers of younger people. Possible reasons include decreased outdoor activities, air pollution and, as people age, a decline in the skin's ability to produce vitamin D.

Some doctors believe overuse of sunscreen lotions has contributed, and say just 10 to 15 minutes daily in the sun without sunscreen is safe and enough to ensure adequate vitamin D, although there's no consensus on that.

Diet sources include fortified milk, which generally contains 100 international units of vitamin D per cup, and fatty fish -- 3 ounces of canned tuna has 200 units.

The Institute of Medicine's vitamin D recommendations are 200 units daily for children and adults up to 50, and 400 to 600 units for older adults.

Cyclops · Family Member Joined: May 13, 2008 Posts: 29

From the ECTRIMS website:

Cyclops

A Phase I/II dose-escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis
J. M. Burton1; S. Kimball2; R. Vieth2; A. Bar-Or3; H. Dosch4; L. Thibault5; S. Kilborn5; C. D'Souza6; R. Cheung4; M. Ursell7; P. O'Connor1
1. St. Michael's Hospital, Toronto, ON, Canada.
2. Mount Sinai Hospital, Toronto, ON, Canada.
3. Montreal Neurological Institute, Montreal, QC, Canada.
4. Hospital for Sick Children, Toronto, ON, Canada.
5. McGill University, Montreal, QC, Canada.
6. University of Toronto, Toronto, ON, Canada.
7. Etobicoke General Hospital, Etobicoke, ON, Canada.

Increasing distance from the equator, low UV radiation and low serum 25-hydroxyvitamin D [25(OH)D] are associated with increased multiple sclerosis (MS) prevalence and risk. While this relationship provides insight into prevention, it begs the question, ‘Is vitamin D3 (VD3), known to have immunoregulatory properties, beneficial in established MS?’ To answer this, a safe, effective dose must be determined.

To characterize the safety profile of high-dose oral VD3 in MS.

A prospective controlled 52-week trial matched MS patients for demographic and disease characteristics, randomizing them to treatment or control groups. Treatment patients started VD3 at 4000 IU/day and escalated over 28 weeks to 40 000 IU/day. This was followed by maintenance with 10 000 IU/day for 12 weeks, 4000 IU/day for 8 weeks and a 4-week wash-out, translating into roughly 14 000 IU/day over 52 weeks. Calcium (1200mg/day) was given throughout the trial. The primary endpoint was mean change in serum calcium in treatment patients at each VD3 dose, and a comparison of calcium between treatment and control groups. Secondary endpoints included 25(OH)D, urine calcium/creatinine (Ca/Cr) and PTH. Cytokines, lymphocyte response and matrix metalloproteinase-9 were also measured, as were Expanded Disability Status Scale (EDSS) and relapses.

Forty-nine patients were enrolled (25 treatment, 24 control) with mean age 40.5 years (21–54 years), EDSS 1.34 (0-6.0) and 25(OH)D 78nmol/l (38–154). No abnormalities or differences in serum calcium, urine Ca/Cr or PTH occurred, nor were there differences in calcium between groups. Despite a maximum mean 25(OH)D of 413nmol/l (66–729), no significant clinical or biochemical adverse events occurred. A greater proportion of treatment patients had stable/improved EDSS vs. control patients (p=0.018). Treatment patients also had fewer relapses and a greater reduction in relapse rate vs. controls. Immunological data will be presented.

High-dose VD3 (~10 000 IU/day, possibly higher) in MS is safe and tolerable, with evidence of clinical improvement.

cheerleader · Posted: Thu Oct 30, 2008 8:18 am Post subject: Re: Vitamin D News

Edit...
just reread the thread and noticed NHE posted the article last June. There's been alot of press on vit. D in the past few months-

"Exactly how low vitamin D levels might contribute to heart problems and deaths from other illnesses is uncertain, although it is has been shown to help regulate the body's disease-fighting immune system, he said."

Thanks for the links guys. That quote from the article is interesting. We DO have research linking vitamin D to endothelial dysfunction.

Many doctors now understand that vitamin D deficiency leads to oxidative stress, artherosclerosis, and heart disease. Vitamin D supplementation improves lipid peroxidation and heals the endothelium.
http://www.endocrine-abstracts.org/ea/0014/ea0014p275.htm
http://ajpheart.physiology.org/cgi/content/abstract/00116.2008v1

This is no longer a mystery...the endothelium connects every system in the body, from vasculature to the blood brain barrier. And vitamin D supplementation can help heal breeches in this system. The institute's daily rec. is WAY too low...we're doing 4,000IU daily, and the ECTRIM study shows 10,000IU is safely tolerated.
AC
_________________
Husband diagnosed RRMS March 2007
pursuing endothelial healing
Copaxone, Swank, supplements, laughter