Fruit juices and drug absorbtion

Frank · Posted: Wed Aug 20, 2008 5:34 am Post subject: Fruit juices and drug absorbtion

How do you feel about that? Will it have an impact your diet?
--Frank

http://www.sciencedaily.com/releases/2008/08/080819160050.htm
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Current regime: Tysabri restarted 05/2008 after LDN, ABX Wheldon Regime for 1 year, interested in T-Cell vaccination, helminth immunomodulation

VodooDoll · Posted: Wed Aug 20, 2008 10:36 am Post subject:

Thanks for posting this. I knew about the orange & apple juice..not the grapefruit juice.

Very helpful!

NHE · Volunteer Moderator Joined: Nov 21, 2004 Posts: 769

Here's a paper relevant to the topic and which may be of interest to MS folks.

Grapefruit juice can increase the plasma concentrations of oral methylprednisolone.
Eur J Clin Pharmacol. 2000 Sep;56(6-7):489-93.

OBJECTIVE: To investigate whether the pharmacokinetics of orally administered methylprednisolone and plasma cortisol concentrations are affected by administration of grapefruit juice. METHODS: In a randomised, two-phase, cross-over study, ten healthy subjects received either 200 ml double-strength grapefruit juice or water three times a day for 2 days. On day 3, 16 mg methylprednisolone was given orally with 200 ml grapefruit juice or water. Additionally, 200 ml grapefruit juice or water was ingested 0.5 h and 1.5 h after methylprednisolone administration. Plasma concentrations of methylprednisolone and cortisol were determined using liquid chromatography/mass spectrometry (LC/MS/MS) over a 47-h period. RESULTS: Grapefruit juice increased the total area under the plasma methylprednisolone concentration-time curve (AUC 0--infinity) by 75% (P < 0.001) and the elimination half-life (t1/2) of methylprednisolone by 35% (P < 0.001). The peak plasma concentration of methylprednisolone (Cmax) was increased by 27% (P < 0.01). Grapefruit juice delayed the time to the Cmax from 2.0 h to 3.0 h (P < 0.05). There was no significant difference in the plasma cortisol concentrations, measured after methylprednisolone administration, between the water and grapefruit juice phases. However, grapefruit juice slightly decreased the morning plasma cortisol concentrations before methylprednisolone administration (P < 0.05). CONCLUSIONS: Grapefruit juice given in high amounts moderately increases the AUC 0--infinity and t1/2 of oral methylprednisolone. The increase in t1/2 suggests that grapefruit juice can affect the systemic methylprednisolone metabolism. The clinical significance of the grapefruit juice-methylprednisolone interaction is small, but in some sensitive subjects high doses of grapefruit juice might enhance the effects of oral methylprednisolone.

NHE

whyRwehere · Family Member Joined: Oct 04, 2005 Posts: 87

what bothers me about this news, is that the media says juice isn't good for you, when what they should say is: juice isn't good for you, if you are taking medication.