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read: "you can get as much sun as you want but if you have certain screwed up vitamin D receptors, you're in for it anyway".
which i take to mean, if you don't have the right receptor functionality your body can't effectively undertake the first and second hydroxylations of cholecalciferol needed to get your immune system functioning effectively.
not covered in the abstract:
UNLESS... you were to input dietary or pharmaceutical forms that were already hydroxylated, at least to 25-hydroxycholecalciferol (25OHD).
i don't know enough details of the d3 process to say whether this study indicates anything about capacity to complete the second hydroxylation to 1,25 dihydroxycholecalciferol - 1,25(OH)2D3. i can't quickly find any foods that already contain that form, but i'd guess that if you eat something with 25OHD, it probably has 1,25(OH)2D3 too.
I agree the abstract is a little THIN shall we say for any interpretation and I agree with Jimmy but want to add that 1,25 dihydroxyvitamin d is always made in the body through hydroxylation of 25OH d either by the kidneys or sometimes by activated macrophages locally. It is never ingested.
It is the active form of the vitaim and is essentially a hormone so it is tightly regulated and created by the body only at need and in response to parathyroid hormone, calcuim levels and overall d status.
Personally my d status, both 1,25d and 25d are in the 60 range.
It'd be interesting to read the whole citation and see if they correlate their material to d status, both 25 and 1,25d, to draw the conslusions.
interesting, m. so you can't eat a critter that has previously hydroxylated d3 to the 1,25 form? or is it that even if you do, it doesn't do anything for your immune system? i'm sure i have read about dietary supplementation with 1,25 (OH)2D3 though... in chickens mostly, but still. i just can't find an example of a regular food that specifically mentions this as a component. i'm still going to try to track down whether there are foods with 25OHD3 in them that also have 1,25(OH)2D3. to me it makes sense that something would. and of course we also do make it in our own bodies, predominantly in the kidneys as you noted.
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