Teriflunomide

tobi · Posted: Sat Dec 12, 2009 10:14 am Post subject:

here you can look for the different teriflunomide trials:

http://clinicaltrials.gov/ct2/results?term=teriflunomide[/url]

domheldercamara

My MD asked me if I was interested in participating in the phase III study as I am pretty well petrified of needles...
I am reading the consent form and it says something to the effect that the drug has shown (in test tube studies) alterations to DNA- and can potentially cause cancer..but there is no proof yet in humans.
Rolling Eyes

It makes me equally nervous.
Can anyone speak to the effects the drug has had on them. I understand that hair loss is one of them- its the cancer that really scares me, any words of advice?

Thanks Smile

DM · Posted: Fri Dec 18, 2009 7:14 pm Post subject:

Dom,

I'm in Ottawa as well. Just finished up the 2 year trial. Now I am on the expanded trial. Except for some thinning of the hair, no sidefx whatsoever.

Don't worry about it. They'll look after you well with frequent visits, ultrasounds, and MRIs.

Guess you are at the General?

domheldercamara · Posted: Sun Dec 20, 2009 10:15 pm Post subject: Teriflunomide

Hey DM,

Thanks for making me less nervous about teriflunomide. I will be at the General with Dr. Christie for the trials.

I am glad to know that there is someone on the forum not only in proximity, but on the same trial.

Thanks again, I think now I will have less trepidation to try this drug out.

DM · Posted: Fri Jan 01, 2010 5:07 pm Post subject:

It may be the same drug but a different trial. As far as I know, I was the last at the clinic to be in the particular study.

Jaguar · Posted: Wed Jan 06, 2010 12:55 pm Post subject:

I have been in trials for I think it is now 8 years. Definite hair thinning - happened right at the beginning, then stopped.

But hey, I'm a guy, what can I really expect?

DM · Posted: Wed Jan 06, 2010 1:52 pm Post subject:

Did it just stop, or start to grow back a bit once the body adjusted to the drug?

Jaguar · Posted: Wed Jan 06, 2010 2:15 pm Post subject:

No growing back

just thinner and thinner over 4 years or so
now stable

DM · Posted: Thu Jan 07, 2010 9:34 pm Post subject:

At the rate its going lately, I won't have any left in 2 years, and I did have a lot of hair on my head. I am not happy!

MartynW · Newbie Joined: Jun 08, 2009 Posts: 8

So, it seems I have 3 new lesions, so am washing out of the drug next week. Oh well, was worth a try. 9 months, no symptoms, perhaps the Placebo, will never know.

Looking into Avonex now.

tbh, its good timing, i was about to go travelling for a year, and the drug company was insist that i travel back to London every 6 weeks for blood tests, which would have been expensive.

Still don't have MS by definition, but as the Doctor says "the ongoing activity is highly suggestive".

Good news in the paper yesterday

Hope for MS pill after cladribine and fingolimod trials
http://news.bbc.co.uk/1/hi/health/8470138.stm

sneakypuss_01 · Posted: Mon Apr 19, 2010 5:56 am Post subject:

Hi All

Just wanted to let you know that I am participating in the phase III trial here in Australia.

I get put into 'randomization' ion May 4th. So far, I am only the second person at my MS Clinic to go into the trial.

Hope everyone is well.
Sneaky P
_________________
There's not brain lesions...their bright ideas.
DX July 1st 2009 RRMS

sneakypuss_01 · Posted: Wed Apr 21, 2010 12:19 am Post subject:

For those interested in the trial, here's the offical website:

http://tower3.msstudies.com/index.php
_________________
There's not brain lesions...their bright ideas.
DX July 1st 2009 RRMS

DM · Posted: Wed Apr 21, 2010 3:34 pm Post subject:

I completed the Phase 3 trial this past November. Haven't found out yet what I was taking. On the extended study now, and on the real thing, 7 or 14mg. No noticeable differences except my hair has thinned. No sfx whatsoever. Good luck and let us know how you progress!

sneakypuss_01 · Posted: Tue May 04, 2010 4:51 am Post subject:

Hey DM

Well, I got given something today...frustrating that we can't know what it is, but I do understand why.

Will definitely keep you posted on my progress.
_________________
There's not brain lesions...their bright ideas.
DX July 1st 2009 RRMS