CCSVI RESEARCH here

kenneb9

http://jrsm.rsmjournals.com/cgi/content/full/99/11/589
Zamboni
Royal Society of medicine

mrhodes40 · Posted: Tue Jan 26, 2010 11:53 am Post subject:

I added a link to Dr B Lee's new paper on venous malformation in the replicating studies section....page one post 2 of this thread.

The big links are so numerous now it is hard to keep them organized...that seemed the best location for the new information. Any better ideas let me know.
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Regimen thread

thisisalex · Posted: Tue Jan 26, 2010 1:29 pm Post subject: Re: Haacke MR prot.

Dear administrator,

please do update the first post with this document, becauseits a very good and detailed document about dr Haacke's knowledge:

AndrewKFletcher · Posted: Wed Jan 27, 2010 4:27 am Post subject:

Thanks Alex.
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William57 · Posted: Wed Jan 27, 2010 7:02 am Post subject: Re: Haacke MR prot.

thisisalex · Posted: Sun Jan 31, 2010 10:54 am Post subject: Re: Haacke MR prot.

thisisalex · Posted: Sun Jan 31, 2010 10:55 am Post subject:

I have just checked Hacke's site and it looks like there is a protocol for 1.5 Tesla also (not just for 3 Tesla)
http://www.ms-mri.com/potential.php

alex

Sotiris · Posted: Sun Jan 31, 2010 1:59 pm Post subject: Re: Haacke MR prot.

zap · Family Elder Joined: Apr 21, 2009 Posts: 298

Hmm, did the paper I found get snipped on purpose or just get left out in a revision? It's not medical research, but I think it's VERY darn interesting and relevant anyway:

Social constructionism and medical sociology: a study of the vascular theory of multiple sclerosis

http://www3.interscience.wiley.com/cgi-bin/fulltext/119454590/PDFSTART

... and from the late 80s!

(edited to fix link to full text)

taxi · Posted: Sun Feb 07, 2010 1:37 am Post subject:

fiddler · Posted: Fri Mar 12, 2010 11:19 am Post subject: Another kind of research

Folks, as reported in the posting http://www.thisisms.com/ftopicp-97519-intelligence.html#97519, it is good to know that Charity Intelligence Canada has, on the basis of its own analysis, recommended to institutional and private donors that CCSVI research in Canada should be a high priority target for donations since it is likely to produce tremendous social and economic dividends.

Perhaps others outside of Canada should bring this to the attention of similar organizations in their own countries, since it would bring CCSVI research to the attention of donors who might otherwise not be aware of the potential value of CCSVI research and intervention.

The Ci report itself can be found at: http://charityintelligence.ca/pdfs/Ci_CCSVI_in_Canada_FINAL_Disclaimer.pdf

...Ted
_________________
Dx SPMS in 2004. Liberated 29/04/2010.
My blog: www.my-darn-ms.blogspot.com

sbr487 · Posted: Mon Mar 22, 2010 2:38 am Post subject:

I dont know if anyone has seen this paper. Its more like a summary of work Dr. Z has carried out.

http://www.fondazionehilarescere.org/pdf/CX.PDF

Rose2 · Posted: Sat Mar 27, 2010 3:36 pm Post subject:

Hi. Just wondering if I post will this Bump the RESEARCH Sticky to the top of the Stickies?? It seems like the RESEARCH Sticky should hold the top slot for newcomers. just my thoughts. Rose Smile

eric593 · Family Elder Joined: Feb 18, 2008 Posts: 255

http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=historysearch&querykey=1

April, 2010 International Journal of Angiology, etc.

Multiple articles on CCSVI (#1-12) on Pub-Med list (at link and below)

1. Chronic cerebro-spinal venous insufficiency: report of transcranial magnetic stimulation follow-up study in a patient with multiple sclerosis.

Plasmati R, Pastorelli F, Fini N, Salvi F, Galeotti R, Zamboni P.

Int Angiol. 2010 Apr;29(2):189-92.
PMID: 20351675 [PubMed - in process]

2. Hemodynamic patterns of chronic cerebrospinal venous insufficiency in multiple sclerosis. Correlation with symptoms at onset and clinical course.

Bartolomei I, Salvi F, Galeotti R, Salviato E, Alcanterini M, Menegatti E, Mascalchi M, Zamboni P.

Int Angiol. 2010 Apr;29(2):183-8.
PMID: 20351674 [PubMed - in process]

3. Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study.

Malagoni AM, Galeotti R, Menegatti E, Manfredini F, Basaglia N, Salvi F, Zamboni P.

Int Angiol. 2010 Apr;29(2):176-82.
PMID: 20351673 [PubMed - in process]

4.Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study.

Zivadinov R, Schirda C, Dwyer MG, Haacke ME, Weinstock-Guttman B, Menegatti E, Heininen-Brown M, Magnano C, Malagoni AM, Wack DS, Hojnacki D, Kennedy C, Carl E, Bergsland N, Hussein S, Poloni G, Bartolomei I, Salvi F, Zamboni P.

Int Angiol. 2010 Apr;29(2):158-75.
PMID: 20351672 [PubMed - in process]

5. Iron stores and cerebral veins in MS studied by susceptibility weighted imaging.

Haacke EM, Garbern J, Miao Y, Habib C, Liu M.

Int Angiol. 2010 Apr;29(2):149-57.
PMID: 20351671 [PubMed - in process]

6. CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies: a pilot study.

Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojnacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, Ramanathan M, Zivadinov R.

Int Angiol. 2010 Apr;29(2):140-8.
PMID: 20351670 [PubMed - in process]

7. Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls.

Hojnacki D, Zamboni P, Lopez-Soriano A, Galleotti R, Menegatti E, Weinstock-Guttman B, Schirda C, Magnano C, Malagoni AM, Kennedy C, Bartolomei I, Salvi F, Zivadinov R.

Int Angiol. 2010 Apr;29(2):127-39.
PMID: 20351669 [PubMed - in process]

8. The reproducibility of colour Doppler in chronic cerebrospinal venous insufficiency associated with multiple sclerosis.

Menegatti E, Genova V, Tessari M, Malagoni AM, Bartolomei I, Zuolo M, Galeotti R, Salvi F, Zamboni P.

Int Angiol. 2010 Apr;29(2):121-6.
PMID: 20351668 [PubMed - in process]

9. Internal jugular vein morphology and hemodynamics in patients with multiple sclerosis.

Al-Omari MH, Rousan LA.

Int Angiol. 2010 Apr;29(2):115-20.
PMID: 20351667 [PubMed - in process]

10. Extracranial Doppler sonographic criteria of chronic cerebrospinal venous insufficiency in the patients with multiple sclerosis.

Simka M, Kostecki J, Zaniewski M, Majewski E, Hartel M.

Int Angiol. 2010 Apr;29(2):109-14.
PMID: 20351666 [PubMed - in process]

11. Embryological background of truncular venous malformation in the extracranial venous pathways as the cause of chronic cerebro spinal venous insufficiency.

Lee AB, Laredo J, Neville R.

Int Angiol. 2010 Apr;29(2):95-108.
PMID: 20351665 [PubMed - in process]

12. Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis.

Marrie RA, Rudick R, Horwitz R, Cutter G, Tyry T, Campagnolo D, Vollmer T.

Neurology. 2010 Mar 30;74(13):1041-7.
PMID: 20350978 [PubMed - in process]

SoberSandy · Posted: Sun Apr 04, 2010 10:02 pm Post subject:

NEUROLOGY 2010;74:1041-1047
© 2010 American Academy of Neurology
Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis
R.A. Marrie, MD, PhD, R. Rudick, MD, R. Horwitz, MD, G. Cutter, PhD, T. Tyry, PhD, D. Campagnolo, MD and T. Vollmer, MD
From the Department of Medicine (R.A.M.), University of Manitoba, Winnipeg, Canada; Neurological Institute (R.R.), Cleveland Clinic, Cleveland, OH; Department of Medicine (R.H.), Stanford University, Stanford, CA; Department of Biostatistics (G.C.), University of Alabama at Birmingham; and Division of Neurology (T.T., D.C., T.V.), Barrow Neurological Institute, Phoenix, AZ.
Address correspondence and reprint requests to Dr. Ruth Ann Marrie, Health Sciences Center, GF-533, 820 Sherbrook Street, Winnipeg, MB R3A 1R9, Canada rmarrie@hsc.mb.ca .
Background: Vascular comorbidity adversely influences health outcomes in several chronic conditions. Vascular comorbidities are common in multiple sclerosis (MS), but their impact on disease severity is unknown. Vascular comorbidities may contribute to the poorly understood heterogeneity in MS disease severity. Treatment of vascular comorbidities may represent an avenue for treating MS.
Methods: A total of 8,983 patients with MS enrolled in the North American Research Committee on Multiple Sclerosis Registry participated in this cohort study. Time from symptom onset or diagnosis until ambulatory disability was compared for patients with or without vascular comorbidities to determine their impact on MS severity. Multivariable proportional hazards models were adjusted for sex, race, age at symptom onset, year of symptom onset, socioeconomic status, and region of residence.
Results: Participants reporting one or more vascular comorbidities at diagnosis had an increased risk of ambulatory disability, and risk increased with the number of vascular conditions reported (hazard ratio [HR]/condition for early gait disability 1.51; 95% confidence interval [CI] 1.41–1.61). Vascular comorbidity at any time during the disease course also increased the risk of ambulatory disability (adjusted HR for unilateral walking assistance 1.54; 95% CI 1.44–1.65). The median time between diagnosis and need for ambulatory assistance was 18.8 years in patients without and 12.8 years in patients with vascular comorbidities.
Conclusions: Vascular comorbidity, whether present at symptom onset, diagnosis, or later in the disease course, is associated with a substantially increased risk of disability progression in multiple sclerosis. The impact of treating vascular comorbidities on disease progression deserves investigation.
Abbreviations: EDSS = Expanded Disability Status Scale; HR = hazard ratio; MS = multiple sclerosis; NARCOMS = North American Research Committee on Multiple Sclerosis; PDDS = Patient Determined Disease Steps