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Joined: Jul 28, 2005 Posts: 1279 Location: Sydney, Australia
Posted: Tue May 30, 2006 6:08 am Post subject: Chinese herb? FTY720 (fingolimod)
FTY720 (fingolimod) from all my reaading appears to originate from a chinese herb or such. Does anyone know what it is called and if it can be purchased from a chinese remedy store? is it called "fingolimod"?
Posted: Sat Jun 24, 2006 8:57 am Post subject: fungalicious
perhaps it is isaria sinclairii, cure? "Isaria sinclairii, a traditional Chinese medicine composed of the fruiting bodies of I. sinclairii and its parasitic host larva" <shortened url>
also:
so, when you want to read about it in supplement form you look for cordyceps, apparently. this gets far better shopping type results in google than the latin name.
here's where i found the name cordyceps
http://planetherbs-com.site-etc.net/discus/messages/59/490.html?1149367524
and here's one online store selling the supplement but i haven't done really any reading about it and i don't know or use this product or this store:
http://www.1fast400.com/i24_Cordyceps.html
and:
J Antibiot (Tokyo). 1994 Feb;47(2):208-15.
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.
Fujita T, Inoue K, Yamamoto S, Ikumoto T, Sasaki S, Toyama R, Chiba K, Hoshino Y, Okumoto T.
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
A potent immunosuppressive activity was found in the culture broth of the fungus Isaria sinclairii (ATCC 24400). The metabolite, ISP-I ((2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2- hydroxymethyl-14-oxoeicos-6-enoic acid, myriocin = thermozymocidin) suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction, but had no effect on the growth of human tumor cell lines. It also suppressed the appearance of plaque-forming cells in response to sheep red blood cells and the generation of allo-reactive cytotoxic T lymphocytes in mice after intraperitoneal or oral administration. The metabolite was 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo, and appears to be a candidate for clinical application as a powerful immunosuppressant.
Joined: Jul 28, 2005 Posts: 1279 Location: Sydney, Australia
Posted: Sat Jul 08, 2006 1:28 am Post subject:
I got my hands on some "Cordyceps". When I first opened the pack, something smelt very familiar. NOW i have realized that the capsules smell like chocolate cake mix!
Well, isaria sinclairii,(not iscaria !) is not exactly a plant. it is a microscopic fungus. And it does not produce fingolimod and myriocin. Nor efficiently, at least. The right fungus is called Mycelia sterilia , see here:
http://www.fermentek.co.il/myriocin.htm
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Myriocin
Identifiers
CAS number [35891-70-4]
Properties
Molecular formula C21H39NO6
Molar mass 401.54 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox references
Myriocin, also known as Antibiotic ISP-1, Thermozymocidin, is an atypic amino acid, an antibiotic derived from certain thermophilic fungi. Among the producing strains are Mycelia sterilia[1]and Isaria sinclairii.
Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis[2]. Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids.
Myriocin was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line.
Myriocin possesses immunosuppressant activity. It is reported to be 10 to 100 fold more potent than cyclosporin.
I believe sphingolipids play a part in MS
Quote:
1: Expert Opin Investig Drugs. 2007 Mar;16(3):283-9. Links
FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.Baumruker T, Billich A, Brinkmann V.
Novartis Institutes for BioMedical Research, Autoimmunity & Transplantation, Brunner Strasse 59, A-1235 Vienna, Austria. thomas.baumruker@novartis.com
FTY720 (fingolimod; 2-amino-2[2-(4-octylphenyl)ethyl]-1,3-propanediol, Novartis) is the prototype of a new generation of immunomodulators. The drug is the result of extensive chemical derivatisation based on the natural product myriocin, isolated from the ascomycete Isaria sinclairii. FTY720 bears structural similarity to sphingosine, a naturally occurring sphingolipid. As with sphingosine, FTY720 is effectively phosphorylated by sphingosine kinases in vivo and the phosphorylated drug targets G-protein-coupled receptors for sphingosine-1-phosphate (S1P). Gene deletion and reverse pharmacology studies have shown that FTY720 acts at S1P1 receptors on lymphocytes and the endothelium, thereby inhibiting the egress of T- and B cells from secondary lymphoid organs into the blood and their recirculation to inflamed tissues. Animal studies suggest that this novel mechanism translates into effective treatments for several autoimmune diseases and a recently completed Phase II clinical trial highlighted FTY720 as a potential therapy for relapsing-remitting multiple sclerosis.
PMID: 17302523 [PubMed - indexed for MEDLINE]
link _________________ 1st traceable symptoms Jan 01, last edss by doctor 6.5. Feeling better on ginkgo, salvia, capsaicin, curcumin, scutellaria. Interested in other vascular strengthening herbs; pycnogenol, butcher's broom, horsechestnut, centenella, hersperidin
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Carole
