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Posted: Tue Jan 30, 2007 9:06 am Post subject: More evidence on Cannabis for pain
Hopefully regulators around the world get their thumbs out and start approving cannabis in whatever form for MS-related pain.
Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.
Curr Med Res Opin. 2007 Jan;23(1):17-24.
Iskedjian M, Bereza B, Gordon A, Piwko C, Einarson TR.
PharmIdeas Research & Consulting Inc., Oakville, ON, Canada; PharmIdeas USA Inc., Charlotte, NC, USA.
OBJECTIVE: Debilitating pain, occurring in 50-70% of multiple sclerosis (MS) patients, is poorly understood and infrequently studied. We summarized efficacy and safety data of cannabinoid-based drugs for neuropathic pain. Data sources: Studies were identified from Medline, Embase, and Cochrane databases; Bayer Healthcare provided additional trials.
STUDY SELECTION: Accepted were randomized, double-blinded placebo-controlled trials of cannabinoid-based treatments for MS-related/neuropathic pain in adults >/= 18 years of age. Data extraction: Two reviewers identified studies and extracted data; a third adjudicated disagreements. Data included baseline and endpoint pain scores on visual analog or 11-point ordinal scales.
DATA SYNTHESIS: Of 18 articles and three randomized controlled trial (RCT) reports identified, 12 articles and two reports were rejected (9 = inappropriate disease or outcome, 1 = duplicate, 1 = review, and 1 = abstract); six accepted articles and one RCT-report involved 298 patients (222 treated, 76 placebo); four examined Sativex (a cannabidiol/delta-9-tetrahydrocannabinol (THC) buccal spray) (observations = 196), five cannabidiol (n = 41), and three dronabinol (n = 91). Homogeneity chi(2) values were non-significant, allowing data combination. Analyses focused on baseline-endpoint score differences. The cannabidiol/THC buccal spray decreased pain 1.7 +/- 0.7 points (p = 0.018), cannabidiol 1.5 +/- 0.7 (p = 0.044), dronabinol 1.5 +/- 0.6 (p = 0.013), and all cannabinoids pooled together 1.6 +/- 0.4 (p < 0.001). Placebo baseline-endpoint scores did not differ (0.8 +/- 0.4 points, p = 0.023). At endpoint, cannabinoids were superior to placebo by 0.8 +/- 0.3 points (p = 0.029). Dizziness was the most commonly observed adverse event in the cannabidiol/THC buccal spray arms (39 +/- 16%), across all cannabinoid treatments (32.5 +/- 16%) as well as in the placebo arms (10 +/- 4%).
CONCLUSION: Cannabinoids including the cannabidiol/THC buccal spray are effective in treating neuropathic pain in MS.
LIMITATIONS: This review was based on a small number of trials and patients. Pain related to MS was assumed to be similar to neuropathic pain.
Posted: Tue Jan 30, 2007 10:32 am Post subject: Re: More evidence on Cannabis for pain
dignan wrote:
Hopefully regulators around the world get their thumbs out and start approving cannabis in whatever form for MS-related pain.
Meanwhile we see this injustice:
Quote:
Couple escape jail over MS cannabis bars
Patrick Barkham
Saturday January 27, 2007
The Guardian
A couple who supplied thousands of bars of chocolate laced with cannabis to ease the pain of multiple sclerosis sufferers escaped jail yesterday.
Lezley and Mark Gibson, both 42, got nine-month jail sentences, suspended for two years, after being found guilty at Carlisle crown court of conspiring to supply the class C drug. Marcus Davies, 36, who ran a PO box and website for their organisation, received the same sentence.
Judge John Phillips accepted that their motives were "altruistic", but said they had no defence for their "sophisticated" scheme which involved making and distributing up to 100 bars a week from their home in Alston, Cumbria.
"In the case against Mr Gibson I accept that he believed he was correct in what he was doing and that there was no profit," said the judge. "In the case of Mrs Gibson her motive was altruistic and unfortunately she already suffers from MS."
The couple began making the bars after Mrs Gibson found that cannabis greatly improved her condition. She was diagnosed with MS in 1985, but defied predictions that she would be in a wheelchair within five years. They sent free bars to more than 1,600 people - almost 2% of MS sufferers in the country. Police raided their home in 2005 after a bag of the bars spilled open in a sorting office.
Greeted with cheers from supporters after the case, the couple said they were disappointed with the sentence and would appeal against it. They were concerned they could be jailed if Mr Gibson helped his wife to continue taking cannabis.
"This is not a fair sentence. How can it be wrong to help sick people by giving them something that helps them?" said Mrs Gibson. "I cannot not use cannabis. I'm not prepared to be incontinent and in a wheelchair. I'm afraid I'll still be doing what I shouldn't be doing."
She was proud of helping other MS sufferers. Mr Gibson called for an amnesty for medicinal users of cannabis.
Joined: Sep 12, 2006 Posts: 901 Location: Dayton, Ohio USA
Posted: Tue Jan 30, 2007 12:17 pm Post subject:
Amen to that dignan. I'm all about whatever works. Hell, half the stuff we can get for pain is dangerous as hell in the wrong amounts and tends to peter out over time. I can say with confidence from my youth that I don't think you can screw up dosing with marijuana. I have also used it occasionally for that pain that makes your clothes hurt your skin. Not a medical description, but those who get it know what I'm talking aobut. It eliminates that pain temporarily better than anything I've ever tried.
I can't wait until they get the MJ riddle figured out. I think we are only scratching the surface of the good things that MJ can potentially do for us.
Joined: May 26, 2004 Posts: 1383 Location: London, ON, Canada
Posted: Tue Jan 30, 2007 2:58 pm Post subject: Re: More evidence on Cannabis for pain
dignan wrote:
Hopefully regulators around the world get their thumbs out and start approving cannabis in whatever form for MS-related pain.
The Pain Clinic at the London Health Sciences Centre (London, Canada) is so convinced that MJ works for spasms and pain for patients that they are presently conducting a clinical trial with MJ. It is an open label trial and the main end-point of the trial is to study the side effects of patients using MJ vs conventional pain medications.
As the neuro told me...we know it works...we just want to compare the side effects with other medications.
Harry, I'm glad to hear about that trial. I agree with Loobie, the other pain medication choices all seem to have limited effectiveness for neuropathic pain and they all come with side effects too. Canada has its good points and bad points, like any country, but one of the things I'm happy about is our relatively enlightened attitude about cannabis.
Joined: May 26, 2004 Posts: 1383 Location: London, ON, Canada
Posted: Wed Jan 31, 2007 7:48 am Post subject:
dignan wrote:
Harry, I'm glad to hear about that trial. I agree with Loobie, the other pain medication choices all seem to have limited effectiveness for neuropathic pain and they all come with side effects too. Canada has its good points and bad points, like any country, but one of the things I'm happy about is our relatively enlightened attitude about cannabis.
Dignan,
Yes, looking at a drug scientifically rather than politically has its benefits. The neuro told me that they treat MJ just like any other drug and look at what it can do for patients vs the side effects.....just like they do with ANY other drug that is tested or used.
Marg was initially enrolled in the trial but some logistical problems prevented her from participating. She goes to the clinic every 6 months so I'll be talking to the neuro each time and asking how the trial is going.
Joined: Feb 11, 2007 Posts: 12 Location: southeastern NC, US
Posted: Mon Feb 12, 2007 6:49 pm Post subject:
RE:Loobie comment from Jan. 31
I have also used it occasionally for that pain that makes your clothes hurt your skin. Not a medical description, but those who get it know what I'm talking aobut.
Is there a medical term for this? I cannot seem to get across to the docs what I am talking about, and you are the first person I've heard of who has this same thing! Work is agonizing some days because of this.
Joined: Sep 12, 2006 Posts: 901 Location: Dayton, Ohio USA
Posted: Tue Feb 13, 2007 7:14 am Post subject:
Blackdog,
I don't know what the term is, but I've always called it neuropathic pain. My neuro. knows what I'm talking about when I describe it as this, but I'm really not sure. For me, it is very prevelant on my back; especially between the shoulder blades and around the spine.
Joined: Aug 02, 2006 Posts: 133 Location: S. California
Posted: Mon Feb 19, 2007 6:36 pm Post subject: MJ & MS
I appreciate that MJ is beneficial in many ways for people with MS. I unfortunately am not one of them. It is very strange. I have sought relief from pain and tremor through smoking MJ. Bummer is that while I get pain relief my tremor and muscle weakness increases significantly. It happens within a couple of minutes of smoking. I get weak and my muscles tremble when I try to flex at all. What kind of effect is that? Not a good one. I was going to start a trial at UCSD Medical on marijuana for MS, but when I saw how it affected me I decided I did not want to screw up the data for the rest who can benefit.
Has anyone else experienced the type of effects I describe? It so sucks.
Joined: Feb 11, 2007 Posts: 12 Location: southeastern NC, US
Posted: Sat Feb 24, 2007 10:04 am Post subject:
I haven't had the tremors or spasticity that so many other seem to suffer from. Is it painful? What seems to trigger it?
The MJ seems to help so many with the effects of MS.
I attend a local support group here and when I mention pain/extremely sensitive skin/blinding migraines, etc. the others don't seem to get it.
They, on the other hand, cannot stand extreme heat/stress/extended physical activity. These are things that haven't bothered me so far.
I next see my neuro in mid-March and I will be questioning him (again) about the sensitivity to touch, but I will be using new vocabulary.
Maybe that will help.
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Meanwhile we see this injustice:
