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Posted: Mon Apr 21, 2008 9:41 pm Post subject: minocycline vs. doxycycline in CAP protocol
Hello,
I have a few questions about using doxy vs. mino in the CAP protocol. So as I understand it:
* Doxy is officially used in the protocol
* Some people use Mino instead
* Mino may have some neuroprotective properties
My questions are:
1. Is there any reason to believe Doxy would be more (or less) effective than Mino? If they are assumed equal, I'd think Mino would have the edge b/c of its possible neuroprotective qualities
2. Is Doxy possibly neuroprotective as well? Maybe those initial studies just happened to be Mino as opposed to other tetracyclines?
3. Is one or the other more difficult to tolerate in terms of side effects?
4. for those of you who have done the CAP, would you recommend one vs. the other?
Joined: Jun 18, 2004 Posts: 1472 Location: Bedfordshire UK
Posted: Tue Apr 22, 2008 3:31 am Post subject:
Doxycycline is neuroprotective as well, its just that there have been a couple of trials with minocycline to this end. Doxycycline is easier to tolerate, so one would assume better for long term use. As a microbiologist David prefers it for this reason. I took it with roxithromycin rather than azithromycin as the second antibiotic. AS far as tissue penetration this s the best of all and is much easier to tolerate.
Sarah _________________ An Itinerary in Light and Shadow
Completed Stratton/Wheldon antibiotic regime for aggressive secondary progressive MS in June 2007, after four years. Still slowly improving with no exacerbation since starting. EDSS was 7, now 2 or often less.
Doxycycline is neuroprotective as well, its just that there have been a couple of trials with minocycline to this end. Doxycycline is easier to tolerate, so one would assume better for long term use. As a microbiologist David prefers it for this reason. I took it with roxithromycin rather than azithromycin as the second antibiotic. AS far as tissue penetration this s the best of all and is much easier to tolerate.
Sarah
thank you! do you mean, doxy is better than mino for tissue penetration... or roxithromycin is better than azithromycin is better for tissue penetration?
Joined: Jun 18, 2004 Posts: 1472 Location: Bedfordshire UK
Posted: Wed Apr 23, 2008 6:37 am Post subject:
Doxy and mino are about the same, but roxi has the most tissue penetration, especially when used in synergy with one of the other two, its also the most easily tolerated. That's why I was prescribed it in the first place.
Sarah _________________ An Itinerary in Light and Shadow
Completed Stratton/Wheldon antibiotic regime for aggressive secondary progressive MS in June 2007, after four years. Still slowly improving with no exacerbation since starting. EDSS was 7, now 2 or often less.
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