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Posted: Thu Nov 18, 2004 11:24 am Post subject: Which Supplements for Neuroprotection & MS?
Odduck wrote:
Raising BDNF is only one of many ways to help provide neuroprotection. Maintaining neuronal (via ion channels) sodium density is also a form of neuroprotection. (Keppra - i.e. levetiracetam - helps to provide neuroprotection, also.) Most of the AEDs have neuroprotection mechanisms of action. There are several neurotrophins that will help provide neuroprotection.
And can/should it be inexpensive? Absolutely! It's fairly easy to find substances/drugs that will assist with neuroprotection.
Neuroprotection is a major part of helping MS.
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I am wondering what we can take for Neuroprotection that is non prescription. How do we raise sodium density, eat more salt?
Joined: Jul 11, 2004 Posts: 93 Location: Minnesota, USA
Posted: Thu Nov 18, 2004 11:41 am Post subject:
Check out www.eniva.com
I've been using there VIBE product along with some others since October and with the combination with LDN I have felt much better than I did 6 months ago. Small steps, as in various items are starting to get somewhat better. PM me and I can give you some contact info. Listen to a 15 minute phone presentation. 1-888-363-9480 it's a toll free number.
Joined: Sep 26, 2004 Posts: 211 Location: Bristol, England
Posted: Thu Nov 18, 2004 12:27 pm Post subject:
Ibuprofen seems like a good bet
Quote:
Some, but not all, nonsteroidal anti-inflammatory agents (indomethacin and ibuprofen in particular) also have activating effects on PPARgamma. DISCUSSION AND CONCLUSIONS: These observations suggest on the one hand a role for PPARgamma-activating drugs in the treatment of chronic neuroinflammatory diseases-as shown for a patient with secondary progressive multiple sclerosis by Pershadsingh et al.
Quote:
We have developed quantitative in vitro assays for measuring neurotoxicity of microglia or other mononuclear phagocytes. Neuronal like SH-SY5Y cells are cultured in supernatants from activated cells of the human monocytic THP-1 line and their survival is followed. Respiratory burst is directly measured on the activated cells. We tested inhibitors of the cyclooxygenase (COX) or the 5-lipoxygenase (5-LOX) pathways as possible neuroprotective agents. The COX pathway generates inflammatory prostaglandins, while the 5-LOX pathway generates inflammatory leukotrienes. We found that inhibitors of both these pathways suppressed neurotoxicity in a dose-dependent fashion. They included the COX-1 inhibitor indomethacin; the COX-2 inhibitor NS-398; the mixed COX-1/COX-2 inhibitor ibuprofen; the nitric oxide (NO) derivatives of indomethacin, ibuprofen and flurbiprofen; the 5-LOX inhibitor REV 5901; and the 5-LOX activating protein (FLAP) inhibitor MK-886. The FLAP inhibitor also reduced respiratory burst activity in a more potent manner than indomethacin. Combinations of COX and 5-LOX inhibitors were more effective than single inhibitors. The data suggest that both COX inhibitors and 5-LOX inhibitors may be neuroprotective in vivo by suppressing toxic actions of microglia/macrophages, and that combinations of the two might have greater therapeutic potential than single inhibitors of either class
Joined: Jun 20, 2004 Posts: 1040 Location: Tennessee
Posted: Thu Nov 18, 2004 1:37 pm Post subject:
Robin,
That's like my "thing" with norepinephrine! HAH!
SammyJo, the "sodium density" that I referred to isn't directly related to "salt". It's regarding ions and the ion channels between neurons - electrical impulses, etc. Difficult to explain, but salt "intake" isn't what I'm referring to. It's like "calcium influx". It's not directly related to your dietary intake of calcium at all. It is confusing, though, that they use the same words in biology and physiology, isn't it?
Green tea, antioxidants, Vitamin E, gingko biloba, grapeseed, etc. etc. (as far supplements go) all provide various types of neuroprotection. You can do an internet search and find many types of things (even eating fruit) that helps with neuroprotection. I have to say that "vibe" product that adjanimals referred to just now (I just went and took a peek) goes along with the items I just mentioned! (How coincidental was that?)
Joined: Nov 08, 2004 Posts: 116 Location: Colorado
Posted: Fri Nov 19, 2004 5:37 pm Post subject:
Supplements / COX-2 inhibitor
In a prior post from Robin she quotes information about COX-1 and COX-2 inhibitors. Zyflamend (patent pending) is a natural supplement which is advertised as a COX-2 inhibitor to relieve the inflammation of arthritis. It was recommended to me for the relieve of sinus pain and headache (this was before I knew of my MS dx) My husband and I have been taking for about five years. He was diagnosed with a form of Lupus about twenty years ago. Has the Zyflamend helped with the MS or the Lupus? - I do not know - I do know that neither one of us has arthritis (and we are 61 years of age), my sinus problems have not gone away, but they are not as troublesome. You can get more information by searching on the word "Zyflamend" - pick your site as there are a few.
Another note about Zyflamend - there are articles which reference its use for prostrate cancer (Columbia University has completed research) and also to replace the arthritis drugs such as Voix.
Sharon
edit: I just realized there is another "Sharon" who posts - I do not want to confuse anyone, so henceforth I will sign off as SharonR.
Joined: Sep 26, 2004 Posts: 211 Location: Bristol, England
Posted: Sat Nov 20, 2004 4:56 am Post subject:
Just a quick reply...
The she is a he!
Don't worry Sharon, no offence taken. Robin is a unisex name, although it appears in the UK to be predominantly used for males whereas in the US it appears to be mostly females.
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