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Joined: Feb 07, 2007 Posts: 24 Location: near Chicago, IL
Posted: Mon Jun 29, 2009 10:21 pm Post subject: Anyone had itching, hives while on Tysabri?
I have noticed about two weeks after my last infusion (I have been on Tysabri for 2 years) that my forearms are very itchy, and there are some hive-like bumps (but no redness). I'm interested in hearing from anyone else who has had these side-effects. How was it treated? (I'm calling my neuro's office tomorrow.)
My wife has been on tysabri for nearly a year and developed these two infusions back. (Hives and weaziness). She has taken a prednisone and an anti-histamine prior to her infusion which has dramatically reduced the reaction.
My understanding is this could be indicative of developing antibodies to ms but these in the most cases are transient so we are continuing with the expectation that it will subside.
I understand that you can test for antibodies in the USA but cant in NZ. Our neurolgist thought it pointless anyway if transient.
I had some itching, and some hives, just a few here and there. Nothing I worried about. They started after about month 8.
Then I developed eosinophilia. My Eo's kept going up... 14%, 20%, 30%... and the Tysabri was discontinued. : (
My bloodwork is normal now.
Except that now I also have rheumatoid arthritis. I didn't before.
No way any of this can be blamed on Tysabri, of course. I've certainly never heard of anyone else getting eosinophilia or RA because of Ty. But... I gotta say I am very wary of trying any other MS meds. Burned out for now.
IIRC, eosinophilia is a marker of severe (or not-so-severe) allergic reaction. What did your doc say about its cause?
RA is characterized by elevated TNF-alpha and interferon gamma blood concentraions, and this situation is typical for Ty users. I don't blame Ty for RA, but it must have definitely contributed to it.
sou _________________ You would make a ship sail against the winds and currents by lighting a bonfire under her deck... I have no time for such nonsense. --Napoleo / You would stop MS by opening up a vein... I have no time for such nonsense --My neuro
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