Inosine experiences

DIM · Posted: Mon Mar 17, 2008 4:18 am Post subject: Inosine experiences

I did read almost every post in this forum regarding the use of inosine for MS but I'd like to have personal depositions about what results good or bad every individual has to mention.
Preferably type or MS and duration, type of other medicines/regimes used, dosage and duration of inosine as a supplement etc.
I collected recently some publications about inosine and are all very promising!
Thanks in advance Wink

Jim

gibbledygook · Posted: Mon Mar 17, 2008 9:31 am Post subject:

I have taken inosine for several years. It has not prevented treatment induced relapses for me.
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1st traceable symptoms Jan 01, last edss by doctor 6.5. Feeling better on capsaicin, scutellaria baicalensis, high dose curcumin

DIM · Posted: Mon Mar 17, 2008 2:01 pm Post subject:

Have you had a blood analysis for uric acid before start inosine?
As I understand it there are so many variations in this disease that every one should investigate by himself what his case is, if you have not had low uric acid before inosine is quite logical to not see any improvement.

jimmylegs · Family Elder Joined: Mar 12, 2006 Posts: 1869

hello, i have yet to get on inosine, but i have had my uric acid levels tested and they are below optimal based on the ms-relevant research. in fact they are typical for ms.

jimmylegs · Family Elder Joined: Mar 12, 2006 Posts: 1869

and ps this is consistent over three separate tests over the course of roughly two years.

CureOrBust · Posted: Tue Mar 18, 2008 2:54 am Post subject:

DIM · Posted: Tue Mar 18, 2008 3:39 am Post subject:

Good points, these publications are not valids then?

<shortened url>

http://www.ncbi.nlm.nih.gov/pubmed/9435251?dopt=Abstract

<shortened url>

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=18479&rendertype=table&id=T1

...sorry for the links!

DIM · Posted: Tue Mar 18, 2008 3:46 am Post subject:

CureOrBust · Posted: Tue Mar 18, 2008 5:49 am Post subject:

DIM · Posted: Tue Mar 18, 2008 6:15 am Post subject:

Dr Aston Emphry suggests it as a crucial supplement for MS but he states is a "harder choice" due to been fairly costy and may result in gout!
Today I'll take wife's blood analysis for uric acid and if it's below normal levels I am going to order inosine, found the following cheap supplier:
http://distributors.ultimatenutrition.com/pdf/620_PureInosine_snf.pdf

cheerleader · Posted: Tue Mar 18, 2008 8:31 am Post subject:

Hi Jim-

My husband has been on inosine since his dx last March, with neuro's blessing. We had his uric acid levels tested at start, which were low (below 3.6 mg) He is now high/normal (around 8 mg) He has blood work every 3 months, and this is part of the test. He has had a good year...no relapse, no progression. He was taking 2mg daily, now is taking 1mg. We'll have levels checked again in June.

We believe inosine is part of the picture for him. No way to prove it...like many things in MS, it's on faith. I had read many of the studies, and felt lead to try this supplement. His docs agreed.

Here's my source... not too expensive.
http://www.vitacost.com/Source-Naturals-Inosine

Good luck with helping your wife. Keep researching, get blood work done on vit B, vit. D, check hormones, adrenal levels, find ways to balance her system. Good nutrition and supplementation can truly help. So can having a supportive spouse.

all the best,
AC
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Husband diagnosed RRMS March 2007
20 lesions brain/spine
Copaxone, Swank, supplements, laughter

jimmylegs · Family Elder Joined: Mar 12, 2006 Posts: 1869

"average" level is 194. i've had that exact result twice. my third (middle) result was 188.
ms-ers in relapse average in the 160s.
remission is in the neighbourhood of 230ish??? can't remember that remission number exactly.
optimal for healthy controls is 290.
gout range is around 350 and up.

cure has totally different numbers, different units - gotta convert to compare.

i'd have to go scour through old posts to find what my units are at this stage, my lab printouts don't include this info! grr!

DIM · Posted: Tue Mar 18, 2008 11:18 am Post subject:

Just took wife's tests, she has uric acid on the low side, 2.9mg%.
I guess this means she may see improvements from inosine supplementation, right?
Thanks for your help.

jimmylegs · Family Elder Joined: Mar 12, 2006 Posts: 1869

i'd be cautious about using the word "improvements".

with certain things, and i think inosine is among them, it's about minimizing future damage by getting yourself out of the "ms average" biochem. i don't think inosine repairs existing damage. sort of like getting your blood levels of vitamin D in the right neighbourhood.

meanwhile, things like vitamin B complex and magnesium can make noticeable differences in some symptoms, if you're low or low-middle in those sorts of nutrients.

DIM · Posted: Tue Mar 18, 2008 12:54 pm Post subject:

Wife's levels of B12 are very high and is probably the reason for elevated hepatic enzyme ALT she has (or due to choline defficiency as have read inadequate choline with high levels of B complex can lead to increased SGPT-ALT levels).