myelin and ccsvi
myelin and ccsvi
In the light of ccsvi, has anyone explained (Dr. Z, Dr. Schelling ...) why myelin is targeted by the immune system?
- Max Planck
- costumenastional
- Family Elder
- Posts: 743
- Joined: Sat Jan 31, 2009 3:00 pm
- Location: Greece
- Contact:
I am not an expert of course but i see your question and i raise you another:
what else is there? i mean, what is the first thing an intruder would meet with, once inside the cns? An educated guess would be that everything in there is covered by myelin sealth.
Hopefully we ll get an answer.
(this is really in a very small nutshell


I am also curious if and how resolving ccsvi affects the myeline problem. I think the problem still exitst after treatment...
Rob
Here is an excerpt from a paper:
http://brain.oxfordjournals.org/cgi/con ... 124/8/1635Histopathological analysis revealed that 48% of the hyperintense areas seen on T2-weighted images represented active lesions, including lesions localized in the normal appearing white matter, without apparent loss of myelin but nevertheless showing a variable degree of oedema, small clusters of microglial cells with enhanced major histocompatibility complex class II antigen, CD45 and CD68 antigen expression and a variable number of perivascular lymphocytes around small blood vessels [designated as (p)reactive lesions]. From the macro-scopically not-visible/not-palpable MRI-detected abnormalities, 58% were (p)reactive lesions and 21% contained active demyelinating lesions. In contrast, visible and/or palpable brain tissue samples mainly contained chronic inactive lesions.
To be frank, I dont know what it means but seems to be implying that myelin loss is not always necessary ...
- Max Planck
http://www.ncbi.nlm.nih.gov/pubmed/20035511
No lymphocytes, which react to antigens. Just macrophages, which scavenge "foreigners" and clean up rubbish.Early loss of oligodendrocytes is a prominent feature in tissue bordering rapidly expanding MS lesions. Macrophage activity is largely an innate scavenging response to the presence of degenerate and dead myelin. Adaptive immune activity involving T and B cells is conspicuous chiefly in recently demyelinated tissue, which may show signs of oligodendrocyte regeneration. The findings suggest that plaque formation has some basis other than destructive cell-mediated immunity directed against a myelin or oligodendrocyte antigen.
we also discussed it in about march of 09 at length in the big thread somewhere.
bottom line oligodendrocytes die...when they die myelin dies too and as Sou points out then the scavengers come to clean up the dead cells, including myelin.
when people have a stroke they produce many myelin active t cells---why? to clean up the myelin which died as a result of the trauma. venous insufficiency causes trauma of several types including hypoxia which is known to cause death of oligo's when it occurs in the brain
http://www.thisisms.com/ftopic-7318-0.html This is my regimen thread
http://www.ccsvibook.com Read my book published by McFarland Health topics
Everytime I see mentioned T-cells and B-Cells this video comes to mind... can't stop it

This is what is called the 'unknownn stressor' in the ABC research, and causes immune reaction against ABC and thus destroys the oligos and myelin.. CCSVI can be the unknown stressorwhen people have a stroke they produce many myelin active t cells---why? to clean up the myelin which died as a result of the trauma. venous insufficiency causes trauma of several types including hypoxia which is known to cause death of oligo's when it occurs in the brain
Hopefully a trial will take place next year.....then we know if the theory is right...
Rob[/quote]
- 1eye
- Family Elder
- Posts: 3740
- Joined: Wed Mar 17, 2010 3:00 pm
- Location: Kanata, Ontario, Canada
- Contact:
I too am interested in this thread but I would like to add another query: my MS seems to come with some fairly serious brain atrophy and cell death. In particular I have seen one of my MRIs that has me much more worried than the fairly standard hyperintense (white) lesions (spots) I had when I was RR. It feature 'black holes' or hypointense (black) spots which are much denser than the hyper-intense (white) spots were. From my diagnosis MRI there was atrophy. I think there is more now. What I'm wondering is if any of the cognoscenti of CCSVI has a logical explanation for this change. It would sure be nice to think after my procedure my brain problems would stop (atrophy and nerve cell death).sou wrote:Well, alive myelin is not targeted by any MS process.
http://www.ncbi.nlm.nih.gov/pubmed/20035511
No lymphocytes, which react to antigens. Just macrophages, which scavenge "foreigners" and clean up rubbish.Early loss of oligodendrocytes is a prominent feature in tissue bordering rapidly expanding MS lesions. Macrophage activity is largely an innate scavenging response to the presence of degenerate and dead myelin. Adaptive immune activity involving T and B cells is conspicuous chiefly in recently demyelinated tissue, which may show signs of oligodendrocyte regeneration. The findings suggest that plaque formation has some basis other than destructive cell-mediated immunity directed against a myelin or oligodendrocyte antigen.
Not a doctor.
-
- Similar Topics
- Replies
- Views
- Last post
-
-
1997 abstract: low mag in ms; myelin link?
by jimmylegs » Fri Jan 18, 2019 11:35 am » in Natural Approach - 0 Replies
- 50 Views
-
Last post by jimmylegs
Fri Jan 18, 2019 11:35 am
-
-
-
Promise for myelin repair in multiple sclerosis
by Petr75 » Sat Oct 06, 2018 4:44 am » in General Discussion - 0 Replies
- 478 Views
-
Last post by Petr75
Sat Oct 06, 2018 4:44 am
-
-
-
Activated FoxO3 blocks myelin production
by crunkz » Thu May 10, 2018 4:53 pm » in MS Etiology and Pathogenesis - 0 Replies
- 642 Views
-
Last post by crunkz
Thu May 10, 2018 4:53 pm
-
-
-
Inside-out model: Altered myelin could trigger immune attack
by frodo » Tue May 08, 2018 5:16 am » in MS Etiology and Pathogenesis - 0 Replies
- 616 Views
-
Last post by frodo
Tue May 08, 2018 5:16 am
-
-
-
CCSVI in MS reviews
by frodo » Fri Aug 17, 2018 2:07 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI) - 0 Replies
- 759 Views
-
Last post by frodo
Fri Aug 17, 2018 2:07 am
-