I wonder if that would make the thalamus and Hypothalamus axis more susceptible to the 'Schelling' back jets then?uprightdoc wrote:The thalamus surrounds the thrid ventricle. The hypothalamus is on the lower front end of the thalamus. MRI is being used to study CSF flow in the third ventricle (thalamus). MS has been associated with enlargement of the third ventricle. The hypothalamus and pituitary are affected by surrounding CSF in the interchiasmatic and suprasellar cisterns. Because of its location beneath the brain, the pituitary is often affected in intracranial pressure problems. Upright MRI is relatively new and very few studies have been done.
The other source of back jets that would be of interest is the C2 and general cervical region that are very common sights for lesions.
I wonder if these are directly caused by CSF back jets,compression and leakage?
The focus on blood circulation and back jets/reflux may be only part of the cause of lesions and BBB leakage, almost as though the CSF leaks outwards and blood leaks inward in different places?
The ET-1 cascade that is noted at lesion sites is almost a red flag to pin point the sites needing the most understanding and focus by technical methods like Cine Upright MRI, imo.