NZer1 wrote:The other aspect that is interesting is how the timing of peoples latitude moves occurs and the development of the immune system and also the accumulation of infectious diseases and reactions to them. If the infections have the ability to modify the immune system such as what happens in Lyme and CPn where macrophages are desensitized to the pathogen and a slow low grade infection process occurs which includes other pathogens also, now that the immune system is deactivated. The biofilms that are building in the system can hide and protect the pathogen from testing and treatments.
When Vit D is involved the VDR system and the pathogen may have and often has modified the apoptosis of the host cells so that Vit D is not able to trigger processes for the immune system and the apoptosis system.
My understanding of the way vitD manages the cell replacement cycle is that it sets off the process by expressing a gene (in the case of skin cells, but not necessarily all cells, the gene is ATP2C1). This expresses a protein that is a calcium (and manganese) receptor. Calcium enters the Golgi apparatus where it binds with a form of ATP and then makes its way to the cell nucleus where it tells the cell to divide.
When the cell divides, vitamin D expresses other genes to activate the immune system components needed to rid the body of the old cell.
All this gets started when the regulatory hormone vitamin D detects that the cell has been injured or is in some way defective. Probably because of some chemical imbalance such as too much or too little calcium or phosphorous, or the ionized forms which are isolated getting into places within the cell where they don't belong.
The process of cleaning up internal defects or pathogens is similar. A gene is expressed. It creates a protein that does something, usually involving causing something like calcium to bind with something else.
So there are lots of opportunities for a pathogen to disrupt some part of these complicated processes. For example, when calcium enters the Golgi apparatus as a part of the cell replacement cycle, the pathogen might be able to bind to the calcium rather than having it bind to the phosphorous in the ATP.
All well and good. Entirely plausible, even if unproven.
Biofilms are external to the cell, but you are suggesting that the bacteria lives within the cell. What's that all about? Different phases in the life cycle of the bacteria?
Rather than "desensitizing" the immune system, if a bacteria were able to disrupt the cell replication cycle, the immune system components necessary to remove the old cell would simply never be activated. The bacteria wouldn't need to modify the immune system, just block cell replication since that would effectively turn off the immune response to a defective cell.
All very interesting, but again, I don't see where this plays a role in disrupting the blood brain barrier which I think has to be at the heart of what is going on in MS.
Care to elaborate?