ISNVD Abstracts are all online now--

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
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cheerleader
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ISNVD Abstracts are all online now--

Post by cheerleader » 7 years ago

Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com

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Post by Rokkit » 7 years ago

Sweet mother, thank you Cheer.

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Post by Rokkit » 7 years ago

It's a freakin' cornucopia. I'll be up all night.

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Post by Cece » 7 years ago

Oh my my my my my.

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Bethr
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Post by Bethr » 7 years ago

Iron Traffic Gene Variants in MS

WOW!
It's the hepcidin gene standing out!
I've posted a lot about this.

hepcidin (HEPC -582 AG).

This is very big!
(and testable :D )

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Post by cheerleader » 7 years ago

have fun reading, sweet geeky friends!!!
Sadly, I need to start dinner for the fam, or they'll riot.
later,
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com

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Post by AMJ » 7 years ago

Thanks Cheer!

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Post by orion98665 » 7 years ago

Thanks Cheer!! "Wow, i thought this abstract was very interesting!"

http://ccsvism.xoom.it/ISNVD/Abstract-I ... n%20AD.pdf

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Post by ErikaSlovakia » 7 years ago

Rokkit wrote:It's a freakin' cornucopia. I'll be up all night.
Me too :D Moreover I learned what cornucopia means :wink:
Erika
Aug. 7, 09 Doppler Ultras. in Poland, left Jugul. valve problem, RRMS since 1996, now SPMS,
- Nov.3,09: one stent in the left jug. vein in Katowice, Poland, LDN, never on DMDs
- Jan. 19, 11: control venography in Katowice - negative but I feel worse

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Post by Cece » 7 years ago

Dr. Zamboni talked about fusion imaging again, as he did at ISET.
FUSION IMAGING TECHNOLOGY FOR INTRACRANIAL
VENOUS INVESTIGATION
Paolo Zamboni, MD
a
, Erica Menegatti, PhD
a
, Gisela Viselner MD
b
,
Fabrizio Calliada MD
c
, Stefano Bastianello,MD
b
.
a
Vascular Disease Center, University of Ferrara, Ferrara, Italy.
b
Fondazione Istituto Neurologico Nazionale Casimiro Mondino, Neuroradiological
Department, University of Pavia, Italy.
c
IRCCS Policlinico “S. Matteo”, Department of Radiology, University of Pavia, Italy
PURPOSE: Transcranial color coded sonography (TCCS), despite the poor definition
of the anatomical details, permits to investigate the cerebral venous flow in different
postural and respiratory conditions related to the physiology of cerebral venous return.
Usual TCCS windows do not permit to insonate the cavernous and petrosal sinuses. The
aim of this study is to investigate the possibility to insonate these sinuses through a
novel trans-cranial approach, the condylar window.
MATERIALS AND METHODS: We investigated 5 subjects by the means of fusion
imaging technology, an advanced ultrasonographic technique consistently used to
combine ultrasounds and MRI in different districts of the human body, but never used
for studying the brain circulation. Fiducial markers have been placed on the forefront of
each patient before the acquisition of MR brain imaging using a 1.5 T scanner.
Subsequently, the subjects underwent TCCS performed with the Esaote MyLab70XVG
ultrasound scanner equipped with Virtual Navigator technology. Venous circulation has
been investigated by using the classic trans-temporal window and the novel
transcondylar approach.
RESULTS: In all subjects fusion imaging technology demonstrates the possibility to
insonate the cavernous sinus and some of the petrosal sinuses through the condylar
window. In addition, the insonation of the Rosenthal and other parenchymal veins
through the classic trans-temporal window, never validated vs MRI in TCCS study, has
been confirmed by this technology.
CONCLUSION: The condylar window can be used for the study of intracranial deep
cerebral venous system and be useful in clinical practice.
http://ccsvism.xoom.it/ISNVD/Abstract-Z ... Fusion.pdf

With the decision to not include the deep cerebral veins as part of the doppler ultrasound criteria (the criteria are down to four now, instead of five; it's like when Pluto got dropped as a planet), there is obviously a need for better imaging of reflux in the deep cerebral veins. Perhaps fusion imaging is it?

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Post by Cece » 7 years ago

Here is Dr. Hubbard's fMRI research!
Results
In healthy control subjects, the task evoked activation in an extensive set of brain areas
(task-positive network), including visual, parietal, temporal and frontal cortices. In MS
patients the task showed significantly reduced (30-70%) activations compared to normal
controls. The default (task-negative) network, in particular the medial prefrontal, posterior
cingulate and cuneus cortices, also showed pronounced differences in MS patientscompared to the normal controls. Specifically, these areas were not suppressed during task
performance in contrast to the expected suppression seen in the normal controls. The time
course of the BOLD response showed greater decay and a more pronounced undershoot as
compared to the control group. Venoplasty resulted in recovery of the task-negative effects
in the default network such that the comparison between controls and post-venoplasty MS
patients showed no significant differences (t-test, p<0.05).
The pair wise t-test of pre- and
post-venoplasty activations confirmed that the default network suppression was increased
post-venoplasty as compared to pre-venoplasty in the same subjects. The task-positive
network on the other hand, did not show significant changes as a result of the procedure.
http://ccsvism.xoom.it/ISNVD/Abstract-Hubbard.pdf

I am very happy to see measureable differences pre- and post-venoplasty. Not sure why the default network improved and the task-positive network did not?

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Post by MrSuccess » 7 years ago

this is the study that I found significant ...

Now . Someone has to duplicate Dr. Hubbard's results .... using his methods . Dr. Zamboni asked the world .... to examine and duplicate his great discovery . I believe this has been done.

However . Our dear Dr. Doepp and his study results ..... seem to be taken at his word ...... someone must duplicate Dr. Doepp's work in order to validate his discovery . If this principle applies to Dr. Zamboni ....... then in all fairness .... Dr. Doepp's work ..... must be put under the microscope ....

I can't wait for someone else to step up ..... and suggest water runs up hill :wink:

In his study .... Dr. Doepp identifies only ONE of his test subjects .... as having CCSVI ..... which was it ..... a pwMS or a healthy control ?

Our CCSVI experts ..... report CCSVI in over 80% of pwMS on a consistent basis.

What a great missed opportunity Dr. Doepp missed by not attending the Bologna conference ........ how convenient .




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zinamaria
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Post by zinamaria » 7 years ago

Oh man..okay I am definitely a geek, and I had no problem getting through Joyce's 'Ulysses'....BUT THIS! I sure hope you other geeks out there can help illuminate the rest of us!

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MrSuccess
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Post by MrSuccess » 7 years ago

zin - lot's of different thing's of interest here ..... yes ..... it can be hard to follow ..... can you specify which item that confuses you ?

I will be happy ..... to give a simplification ...... as best I can ..... on what interests you....


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zinamaria
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Post by zinamaria » 7 years ago

I am laughing now because it's not one specific thing and I wish it were MrSuccess, and I thank you very much for your offer! That is generous of you, so if I actually take the time to read any of them (which is the crux of the matter here) I'll let you know.
In the meantime....hey, did you know the Nile runs North? (smile)

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