I was the one who posted Dr. Ge's other study, which showed microbleeds in the MS brain using 7 Tesla. Jeff and I heard him present his reseach (not yet published) at ISNVD, and it was sobering.
http://www.thisisms.com/forum/chronic-c ... 24352.html
http://ccsviinms.blogspot.com/2014/03/b ... tters.html
More researchers are noting this break in the endothelium, and detecting these microscopic bleeds in the MS brain. At the ISNVD conference, Dr. Yulin Ge recently discussed how 7T MRI technology is allowing us to see tiny hemorrhages in the MS brain which occur before demyelination. This further elucidates the microvascular connection to MS.
From his abstract at the ISNVD:
Being the most common demyelinating disease of the central nervous system, multiple sclerosis (MS) MS has a significant microvascular pathological component as a consequence of the perivascular inflammation. The role of vascular pathology in MS was suggested long ago. Now there is accumulating evidence of a primary vascular pathogenesis in MS. In vivo studies of vascular and hemodynamic impairment in MS may provide insights into the etiology and pathophysiology of MS and offer the potential metrics for assessment of outcome of the disease.
Ge's other research is about an underutilization of oxygen by the MS brain. And underutilization of O2 happens in diabetes, CFS, RA and other disease states. But maybe using the brain more, and keeping those neurons active, might be a better idea than zoning out.
http://cds.ismrm.org/protected/11MProce ... es/601.pdf
Our results are consistent with the findings of the prior PET study (1), suggesting that significant underutilization of oxygen in MS might reflect the diffuse neuronal cells inactive state due to diffuse nature of the disease rather than neuronal tissue loss. The study may raise important questions regarding oxygen metabolism in MS as a component of neurodegeneration that leads to progressive and global neuronal cells dysfunction.
We see this underutilization of O2, or decreased O2 uptake, after stroke:
This also happens in people with very low blood Ph levels, and decreased ability to extract glucose from blood.
People with CSF have this problem, too. It causes exercise intolerence.
lots more to learn.