new Serbian study finds CCSVI by ultrasound in pwMS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
Post Reply
Family Elder
Posts: 9313
Joined: Mon Jan 04, 2010 3:00 pm

new Serbian study finds CCSVI by ultrasound in pwMS

Post by Cece » Tue May 15, 2012 7:27 pm
Morphological and haemodynamic abnormalities in the jugular veins of patients with multiple sclerosis

Vascular Surgery Clinic, Dedinje Cardiovascular Institute, School of Medicine, Belgrade University, Heroja Milana Tepića 1 Street, Belgrade, Serbia


Multiple areas of stenosis and different levels of obstruction of internal jugular and azygous veins (a condition known as cronic cerebrospinal venous insufficiency) recently emerged as an additional theory to the well-known autoimmune concept, explaining etiology of multiple sclerosis (MS). The aim of our study was to evaluate internal jugular vein (IJV) morphology and haemodynamic characteristics in patients with MS and compare it with well-matched healthy individuals and to evaluate the prevalence of venous flow abnormalities in both groups.

Sixty-four patients with clinically proven MS and 37 healthy individuals were included in our study. In all patients, IJV morphology and haemodynamic characteristics were evaluated by colour Doppler sonography as well as venous flow disorder. The patients were classified into four groups according to MS clinical form presentation. The prevalence of morphological and haemodynamic abnormalities in the IJV were assessed.

The presence of stenosing lesion, mostly intraluminal defects like abnormal IJV valves, were observed in 28 patients (43%) in the MS group, and in 17 patients (45.9%) in the control group (P = NS). By adding haemodynamic Doppler information in the IJV venous outflow was significantly different in 42% of MS patients showing flow abnormalities (27/64), as compared with 8.1% of the controls (3/37), P < 0.001.

In our group of patients, patients suffering from MS had significantly more IJV morphological changes and haemodynamic abnormalities when compared with healthy individuals not suffering from MS. These findings can be well demonstrated by non-invasive and cost-effective Doppler ultrasound.

User avatar
Family Elder
Posts: 3741
Joined: Wed Mar 17, 2010 3:00 pm
Location: Kanata, Ontario, Canada

Re: new Serbian study finds CCSVI by ultrasound in pwMS

Post by 1eye » Wed May 16, 2012 12:22 pm

In this study I take flow abnormalities to mean reflux, and stenosis to mean narrowing. This abstract does not give the overlap, which would in most cases result in a CCSVI diagnosis, nor does it include the azygus, which, as has been pointed out many times, is not tested with Doppler Ultrasound.

The problem with using Doppler Ultrasound as an all-or-nothing test for anything is that it is so operator-dependent. So the studies say more about the operators than they do about the patients, even if well-blinded. And there's always the absence of the azygus vein.
This unit of entertainment not brought to you by FREMULON.
Not a doctor.

Post Reply
  • Similar Topics
    Last post