CCSVI in Meniere disease

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
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CCSVI in Meniere disease

Post by frodo » Mon Dec 12, 2016 8:45 pm

Mèniére Disease (MD) is a disorder of the inner ear producing vertigo and hearing loss. Circulatory problems seem to be implicated. The researchers in this article compare CCSVI in MS patients with normal controls and MD patients.

The importance for this forum is that it shows really striking differences between the normal controls and the MS patients that I had not seen previously published, like the division of jugular veins in three levels (IJ1 - IJ3) and the classification by origin of the CCSVI ( for example 30% stenosis in MS vs. 1% in normal controls with CCSVI for level 1)


Some extracts:

IJVs mainly presented a malfunction of the valve leaflets that usually allow the correct outflow of the venous bloodstream and impede back stream. Leaflets appeared to have a reduced motility contributing to the stenosis of the vessel lumen. Bilateral stenosis of the brachiocephalic junction was also detected especially in MS group.

It is interesting to reveal that, although the group is very small, OVD patients show a CCSVI pattern similar to MD, thus it is reasonable to conclude that CCSVI is not an unique entity and that its pattern may be considered disease-specific.

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Re: CCSVI in Meniere disease

Post by 1eye » Fri May 12, 2017 10:20 am ... /6533/6463

I might remind that although used extensively in arterial disease, the term % stenosis is controversial in jugulars due to their non-cylindrical and very changeable shape. A point to remember is that whatever the measure, its relation to bloodflow quantity is a 4th-power one, and also depends on length, total volume and time. It is very complex and depends critically on the vein's smooth muscle's ability to react (which depends, in turn, on the health of mitochondria).
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