A board to discuss future MS therapies in early stage (Phase I or II) trials.
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Progressive MS Pipeline
Replies: 38
by
dignan » Mon Mar 24, 2008 5:12 pm
First post
Upon request, here are the drugs from the pipeline that are being tested for progressive forms of MS. If I've missed anything, please let me know....
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Hi,
The next treatment for SPMS (and also PPMS I guess) will probably be this one:
Expected in US in March 2019
Later (so I guess end of the...
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- 43892 Views
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Last post by CureOrBust
Fri Nov 23, 2018 2:07 am
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Summary of the pipeline
Replies: 432
by
dignan » Tue Aug 02, 2005 10:55 am
First post
Here's a summary I just put together for myself that I thought I'd share. I've compiled all the substances I could find on the net currently in the...
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:-D Thank you for this! When I was diagnosed almost 20years ago at 21years old there were only 2 options, betaseron or Avonex. I just turned 40 and...
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- 163790 Views
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Last post by Tash1217
Thu Jul 24, 2014 1:22 pm
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Depleting EBV infected b-cells therapy
by
frodo » Sun Mar 17, 2019 6:44 am
Depleting EBV with artificial T-cells works, even in progressive stage.
Epstein-Barr virus–specific T cell therapy for progressive multiple...
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Last post by frodo
Sun Mar 17, 2019 6:44 am
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MSRV Retrovirus, phase 2
Replies: 47
by
Fred1208 » Thu Dec 20, 2012 3:05 pm
First post
Hello everybody :smile:
I am involved in the following study, described hereafter.
Mister Hervé Perron, who found the retrovirus, gave more...
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Excellent results for extension study ANGEL-MS given today!
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Last post by Fred1208
Tue Mar 12, 2019 11:01 am
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Drug effectiveness in doubt.
Replies: 6
by
vesta » Sun Oct 26, 2014 2:32 am
First post
On March 21, 2013 it was announced that Professor George C. Ebers, MD, of University of Oxford in London, had been chosen to receive the National MS...
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hi,
here is an interesting link:
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- 1932 Views
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Last post by zen2010
Sun Mar 10, 2019 4:56 am
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Ublituximab Phase II Success
Replies: 2
by
NHE » Thu Mar 07, 2019 5:10 pm
First post
Ublituximab targets CD20 and depletes B cells. Researchers report that their phase II study was successful.
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Thks for the info.
It looks like Rituxan or Ocrevus (Anti- CD20 antibodies).
It's for both RR and PP.
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- 66 Views
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Last post by zen2010
Fri Mar 08, 2019 1:17 am
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- 522 Views
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Last post by frodo
Sun Dec 23, 2018 2:05 am
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Could be this time?
Replies: 1
by
ton » Mon Mar 26, 2018 6:24 am
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The Black Swan we are waiting for?:
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Please take a look:
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- 1250 Views
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Last post by ton
Sat Dec 22, 2018 1:27 pm
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- 544 Views
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Last post by frodo
Fri Dec 21, 2018 6:16 am
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Last post by seeva
Fri Nov 23, 2018 3:03 am
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The Misfortune of MS Drugs
Replies: 6
by
vesta » Wed Mar 21, 2018 3:41 am
First post
THE MISFORTUNE OF MS DRUGS
We have a situation where drug research has restricted itself to
suppressing the immune system reaction. No effort is...
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Nicotinic acid in high doses
- 6 Replies
- 1564 Views
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Last post by Kheuer
Wed Nov 21, 2018 5:35 pm
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Ibudilast phase II successful
Replies: 1
by
NHE » Fri Aug 31, 2018 3:39 pm
First post
Phase 2 Clinical Trial of Oral Ibudilast Demonstrates Slowing of Brain Atrophy in Progressive MS
August 29, 2018
SUMMARY
Results were...
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Regarding Lipoic Acid...
These are high doses. And while it seems safe, we won't know whether it actually improves the lives of people with MS...
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- 1257 Views
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Last post by Zyklon
Sat Sep 01, 2018 9:24 am
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DR.SU METALFE'S COMPANY COULD BE ON THE VERGE OF CURING M.S
Replies: 3
by
seeva » Tue Jul 03, 2018 10:58 pm
First post
Dear friends please read
Dr.Sumetalfe's company LiFNano could be on the verge of curing M.S
Regards
Seeva
Last post
They dont know what MS is. They do not know either why it appears. They cannot be sure about diagnosis excep after an autopsy.
But they claim to...
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- 1241 Views
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Last post by frodo
Thu Jul 26, 2018 8:42 am
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Last post by seeva
Tue Jun 19, 2018 3:01 am
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Has anyone here had BOTOX injections in the bladder ?
Replies: 27
by
dc10 » Thu Feb 07, 2013 1:09 pm
First post
a uro-neurologist has offered me this treatment option of having BOTOX injections in the bladder to improve bladder incontinence symptoms,
he said it...
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With time, I seem to be getting less of a benefit with botox injections for neurogenic bladder. When I first started 5 years ago, the benefit I...
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- 16709 Views
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Last post by Quest56
Mon Jun 11, 2018 10:14 am
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Last post by CureOrBust
Mon May 28, 2018 1:10 am
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Disease modifying therapies - POLL
Replies: 4
by
carpediem » Fri May 04, 2018 9:13 am
First post
Hello everyone!
I am new here. I'm trying to decide between all these different disease modifying therapies. I'm curious to see which one worked...
Last post
Glad to...
Here is a summary of what I follow:
High good fat diet, virtually no vegetables or fruits or carbs. (Vegetables in very small quantities...
- 4 Replies
- 1361 Views
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Last post by ElliotB
Mon May 07, 2018 8:47 am
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Carlos: MS & FMT Treatment
by
seeva » Tue May 01, 2018 11:29 pm
HI FRIENDS GOOD INFO PLEASE READ
Meet Carlos, he was diagnosed with MS (Multiple sclerosis). He tells his story & his journey with FMT and how he...
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- 1026 Views
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Last post by seeva
Tue May 01, 2018 11:29 pm
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BOTOX injections against adductor spasms in the legs?
Replies: 1
by
UWE59 » Sun Apr 01, 2018 4:13 am
First post
Does anybody had BOTOX injections against adductor spasms in the legs?
Regards
Uwe
Last post
Hi,
I had a total of 9 botox injections in my left leg to deal with quite a number of spasticity issues. The adductors are on the inside of the...
- 1 Replies
- 1371 Views
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Last post by Scott1
Sun Apr 01, 2018 4:58 am
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4-aminopyridine-3-methyl hydroxide
Replies: 22
by
Ned » Tue Apr 20, 2010 5:02 am
First post
I had been taking 4-aminopyridine, and was having trouble stabilising on a suitable dose for me, due to side effects.
I had very good results taking...
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Anybody has good results with 4-aminopyridine-3-methyl hydroxide?
Where I can buy it? (To buid capsula is no Problem for me)
Regards
Uwe
- 22 Replies
- 13617 Views
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Last post by UWE59
Sun Apr 01, 2018 4:00 am
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Roche's New MS Drug Set For Early FDA Approval
Replies: 2
by
seeva » Sun Jan 28, 2018 4:45 am
First post
HI FRIENDS PLEASE READ
Roche’s new multiple sclerosis drug Ocrevus set for early FDA approval
regards
seeva
Last post
HI FRIENDS PLEASE READ
Roche’s new multiple sclerosis drug Ocrevus set for early FDA approval
regards
seeva
Article date: Jun 28, 2016
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Last post by NHE
Fri Feb 02, 2018 9:27 pm
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RE:CLEMASTINE FUMARATE MAY REPAIR MYELIN IN PWMS
Replies: 1
by
seeva » Mon Nov 20, 2017 12:58 am
First post
Hi Friends please read
regards
seeva
Last post
Just take plain fumaric acid which is on ebay cheap as chips. Or amazon or a food ingredient supplier (it is E297). The phospholipids in soy lecithin...
- 1 Replies
- 2148 Views
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Last post by sam112233
Wed Dec 13, 2017 12:30 am
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Over-the-counter antihistamine, Tavist, being tested
Replies: 10
by
vw35qrt » Sat Jul 19, 2014 6:27 pm
First post
Is anyone taking this over the counter antihistamine and seeing any improvement in their symptoms?
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So..we now have results of this test out...any opinions?
Can you share a link to those results please?
Try this:
I wonder: So 50 patients...
- 10 Replies
- 4819 Views
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Last post by Marc70
Fri Oct 20, 2017 1:13 pm
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Low Cost High Dose Biotin
Replies: 3
by
ElliotB » Wed Sep 20, 2017 4:00 pm
First post
I have been taking Biotin for years, and for most of that time I have been using Pharmaceutical Grade Biotin Powder (significantly less expensive)....
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Wow! Great deal!!
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- 1735 Views
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Last post by ElliotB
Sun Sep 24, 2017 4:16 am
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MedDay’s Phase 3 Trial - impact on Optic Neuritis failed
Replies: 1
by
ElliotB » Wed Sep 20, 2017 3:40 pm
First post
I just saw this even though it is from a few months ago - hope it is not a duplication on TIMS.
MedDay’s MD-1003 PHASE III Optic Neuritis Trial...
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Dude,
Where do you get your stuff from? This is like 1 1/2 years old....
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- 1500 Views
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Last post by Marc70
Thu Sep 21, 2017 11:24 am
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LIF Therapy. Possible cure?
Replies: 2
by
MSKarateka » Sun Jun 25, 2017 8:40 am
First post
scientist-cambridge-university-may-found-cure-multiple-sclerosis
Your thoughts would be interesting.
Last post
I'm sure it will help the mice. It must be awesome to be a lab mouse, everything cures you.
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Last post by Anunymouse
Wed Sep 20, 2017 12:25 pm
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- 1894 Views
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Last post by seeva
Tue Jun 13, 2017 2:17 am
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- 2181 Views
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Last post by seeva
Wed May 31, 2017 1:04 am
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- 2060 Views
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Last post by seeva
Fri May 19, 2017 6:27 am
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- 0 Replies
- 1974 Views
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Last post by seeva
Tue May 02, 2017 3:16 am
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- 1923 Views
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Last post by seeva
Fri Apr 28, 2017 3:43 am
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RE MS PATIENT WAKS AFTER TAKING HIV DRUGS
Replies: 2
by
seeva » Thu Oct 29, 2015 1:49 am
First post
HI Frends please read
regards
seeva
Last post
It is weird that the manufacturers have still not started a clinical trial, because there is a lot of information about antivirals in MS. Maybe they...
- 2 Replies
- 3230 Views
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Last post by frodo
Fri Apr 28, 2017 1:07 am
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RE; NEW DRUG SHOWN TO SLOW PROGRSSION IN SPMS
Replies: 1
by
seeva » Tue Apr 25, 2017 3:10 am
First post
HI Friends please read
Siponimod can slow down the progression of secondary progressive MS, results from the EXPAND trial have revealed.
regards...
Last post
Great news. Thanks.
- 1 Replies
- 1880 Views
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Last post by frodo
Fri Apr 28, 2017 1:03 am
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Fecal microbiota transplantation
Replies: 5
by
Kronk » Fri Dec 06, 2013 1:13 pm
First post
Its gross, no doubt, but the science behind poop transplants is starting to turn heads in the medical community. For MS it really speaks to the idea...
Last post
something to consider perhaps;
Zinc Deficiency Predicts Fecal Microbiota Transplant Failure in Recurrent Clostridium Difficile Infection...
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- 3627 Views
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Last post by jimmylegs
Wed Apr 26, 2017 5:02 am
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Stem cell treatment for MS
Replies: 1
by
MSyborg » Tue Apr 04, 2017 5:52 am
First post
Is the stem cell treatment for RRMS still out of the question?
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I think that the tests are still happening but no conclusive data has been released. I guess we're still in the waiting game but I check into it a...
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- 1976 Views
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Last post by USHearts
Tue Apr 25, 2017 9:14 am
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NEED HELP
Replies: 1
by
seeva » Sun Apr 16, 2017 3:03 am
First post
HI Friends I need a help
my m.s friend told me that recenly in AUSTRALIAN TV CHANNELS a news about a new drug for m.s which
can improved a lady's m.s...
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Are you perhaps referring to Ocrevus (ocrelizumab)?
- 1 Replies
- 1898 Views
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Last post by ElliotB
Sun Apr 16, 2017 4:06 am
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RE; NEW DRUG FOR BOTH M.S 'OCREVUS
by
seeva » Sat Apr 01, 2017 10:44 pm
HI Friends
a new drug called ocrevus was approved by FDA for both relapsing and progressive for of m.s
please read
regards
seeva
- 0 Replies
- 1971 Views
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Last post by seeva
Sat Apr 01, 2017 10:44 pm
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RE BOTOX TO TREAT MS CHANNEL 9 NEWS
Replies: 1
by
seeva » Mon Feb 13, 2017 3:27 am
First post
HI Friends please see the vidio about this
regards
seeva
Last post
Hi,
I can't believe this is new news. I had 9 shots of botox in my left leg in 2015 and it wasn't a new idea then. It was used in a spasticity...
- 1 Replies
- 1860 Views
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Last post by Scott1
Mon Feb 13, 2017 2:27 pm
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1,250 mls of Prednisone a day
Replies: 5
by
yycmamma » Tue Dec 20, 2016 8:26 am
First post
Hi all!
I haven't been on any official treatment for MS yet (I take cannabis oil), but that's it. Anyway...... I'm starting Prednisone today, and...
Last post
My neurologist also does a short oral steroid burst. He has told me that the research is not showing an actual benefit to IV vs oral.
Side effects...
- 5 Replies
- 2548 Views
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Last post by aetex
Wed Jan 11, 2017 6:19 pm
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- 2011 Views
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Last post by seeva
Mon Dec 26, 2016 7:31 am
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THE MISSING LINK?
by
ton » Tue Dec 20, 2016 8:42 am
Unknown Soldiers: UVA Discovers Powerful Defenders of the Brain
Please take a look:
- 0 Replies
- 2016 Views
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Last post by ton
Tue Dec 20, 2016 8:42 am
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RE: MS DRUGS-WHO IS USING WHAT?
Replies: 1
by
seeva » Wed Oct 26, 2016 10:47 pm
First post
HI Friends please read
regards
seeva
Last post
I started out on the Solumedrol for 3 days straight; then I was put on Tysabri and now I'm on Solumedrol again until I get approved for the Retuximab.
- 1 Replies
- 2343 Views
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Last post by mia72797
Sun Nov 20, 2016 3:06 am
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Question and Info
Replies: 1
by
hbriese07 » Wed Nov 09, 2016 11:06 am
First post
Hello,
I was diagnosed with relapsing/remitting MS in April of 2014. I began Tecfidera mid May of that year. This last summer has been...
Last post
Hello,
If anyone out there has had experience with Tysabri infusions and can shed some insight I would greatly appreciate it!!
Thank you,
Heather...
- 1 Replies
- 2074 Views
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Last post by euphoniaa
Sat Nov 12, 2016 9:11 am
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Should I take drugs or not?
Replies: 4
by
lucy311 » Sun Oct 23, 2016 10:59 am
First post
Hi everyone,
I would like to ask a question that probably all of you were thinking about at some point. My question is how to make a decision about...
Last post
Thank you so much your sincere reply. It is so good to hear you are doing well for such a long time, I understand it is hard to stop taking the drug...
- 4 Replies
- 2363 Views
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Last post by lucy311
Mon Oct 24, 2016 1:56 pm
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Last post by ton
Mon Sep 19, 2016 8:43 am
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Last post by Markd
Sun Sep 04, 2016 7:54 pm
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- 2 Replies
- 3400 Views
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Last post by zen2010
Mon Aug 22, 2016 4:45 am
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Lucky Mice and perhaps us (in the future)
Replies: 3
by
ElliotB » Wed Jul 20, 2016 12:02 pm
First post
According to this article, a company from France called INSERM has successfully tested a drug with mice that seems to prevent MS disease...
Last post
Well...I am not fond of the outdated (IMO) Experimental Autoimmune Encephalomyelitis (EAE) mouse model. Through research and clinical trials many of...
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- 2377 Views
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Last post by Snoopy
Wed Jul 20, 2016 3:44 pm
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- 0 Replies
- 2146 Views
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Last post by ziggystardust23
Sun Jul 10, 2016 8:54 pm
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- 2 Replies
- 2498 Views
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Last post by CureOrBust
Sat Jun 18, 2016 9:02 pm
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