Progressive MS Pipeline

A board to discuss future MS therapies in early stage (Phase I or II) trials.
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zen2010
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Re: Progressive MS Pipeline

Post by zen2010 » 3 years ago

dignan wrote:Upon request, here are the drugs from the pipeline that are being tested for progressive forms of MS. If I've missed anything, please let me know.



Progressive MS Treatment Pipeline - September 2011

Phase 3 Trials
- Gilenya (aka FTY720 and fingolimod) (PPMS) (Novartis)
- Masitinib (SPMS and PPMS) (aka Kinavet or AB1010) (AB Science)
- Ocrelizumab (R1594) (trial for PPMS) (Genentech, Roche, Biogen)
- Revimmune (aka high dose cyclophosphamide or cytoxan) (Accentia Biopharmaceuticals) (refractory MS - includes SPMS I think, not sure about PPMS)

Phase 2 Trials
- Amiloride (Oxford University) (PPMS)
- Fluoxetine (aka Prozac) (SP, PP & RRMS) (University Medical Center Groningen)
- GEM-SP (SPMS) (Gemacbio)
- Hydroxyurea (PPMS) (S. Andrea Hospital)
- Idebenone (National Institute of Neurological Disorders and Stroke)
- Lithium (US Department of Veterans Affairs)
- Mesenchymal Stem Cells (4 trials listed in clinicaltrials.gov)
- MIS416 (progressive MS) (Innate Therapeutics)
- PI-2301 (Peptimmune)
- Pixantrone (aka BBR 2778) (SPMS) (Cell Therapeutics)
- RTL1000 (Artielle ImmunoTherapeutics)
- Zocor (aka simvastatin) (SPMS) (MS-STAT trial - UK)
Hi all,

Can anyone pls update this status?

I tried to find something on the net but didn't get anything...

Thks

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zen2010
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Re: Progressive MS Pipeline

Post by zen2010 » 3 years ago

I found this interesting link below...
https://www.mssociety.org.uk/ms-researc ... peline#PMS

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UWE59
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Re: Progressive MS Pipeline

Post by UWE59 » 2 years ago

zen2010 wrote:I found this interesting link below...
https://www.mssociety.org.uk/ms-researc ... peline#PMS
This link is not available.
Kind regards UWE

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NHE
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Re: Progressive MS Pipeline

Post by NHE » 2 years ago

UWE59 wrote:
zen2010 wrote:I found this interesting link below...
https://www.mssociety.org.uk/ms-researc ... peline#PMS
This link is not available.
It works for me when I click on it.

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zen2010
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Re: Progressive MS Pipeline

Post by zen2010 » 2 years ago

NHE wrote:
UWE59 wrote:
zen2010 wrote:I found this interesting link below...
https://www.mssociety.org.uk/ms-researc ... peline#PMS
This link is not available.
It works for me when I click on it.
Hi,

Forget about the previous link and try the one below:
http://www.nationalmssociety.org/Resear ... #section-0

BR

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seeva
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Re: LIPOIC ACID AN OVER THE COUNTER ANTIOXIDANT, SEEN TO SLO

Post by seeva » 1 year ago

HI Friends please read
https://multiplesclerosisnewstoday.com/ ... -patients/
regards
seeva

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zen2010
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Re: Progressive MS Pipeline

Post by zen2010 » 2 months ago

Hi,

The next treatment for SPMS (and also PPMS I guess) will probably be this one:
https://multiplesclerosisnewstoday.com/ ... -for-spms/

Expected in US in March 2019
Later (so I guess end of the year) in Europe

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NHE
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Re: Progressive MS Pipeline

Post by NHE » 2 months ago

zen2010 wrote:The next treatment for SPMS (and also PPMS I guess) will probably be this one:
https://multiplesclerosisnewstoday.com/ ... -for-spms/

Expected in US in March 2019
Later (so I guess end of the year) in Europe
Regarding Siponimod, it sounds like PML could be a potential problem.

https://multiplesclerosisnewstoday.com/ ... 2-for-spms
Siponimod works by stopping the immune cells from entering the brain and spinal cord, preventing them from causing inflammation and damage to the myelin sheath.

Siponimod does this by binding to the sphingosine-1-phosphate (S1P) receptor found on the outside of immune cells, blocking its normal action. It interacts specifically with S1P receptor 1 and 5. The S1P receptor is important to trigger the release of immune cells from the lymph node and into the circulating blood. Siponimod keeps the immune cells trapped in the lymph node, slowing MS disease progression.
and...

https://mymsaa.org/publications/msresea ... siponimod/
Siponimod is a drug with a mechanism of action similar to Gilenya. Like Gilenya, it works at the S1P receptor family to block the movement of lymph cells from lymph nodes, however, siponimod appears to interact with less of the receptors than Gilenya does – with its primary actions at the S1P1 and the S1P5 receptors. Siponimod has a relatively short half-life compared to Gilenya, which means that the drug does not stay in the body as long. Researchers hope that these small differences will minimize cardiac issues.

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CureOrBust
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Re: Progressive MS Pipeline

Post by CureOrBust » 1 month ago

zen2010 wrote:Hi,

The next treatment for SPMS (and also PPMS I guess) will probably be this one:
https://multiplesclerosisnewstoday.com/ ... -for-spms/

Expected in US in March 2019
Later (so I guess end of the year) in Europe
This trial http://www.thisisms.com/forum/drug-pipe ... 30179.html has already started. I am registered for the trial, but am on a wash out period of Gilenya (ie Siponimod's older brother); 9 months, so my first dosing is in feb Image. They have run a previous trial using autologous cells, and previous to that, a single original trial patient. From my understanding the original single guy improved, the second trial was supposedly successful based on a company bought up the rights, and is now running an allogeneic based trial. (see link, in the link) I reiterate, this trial has already started dosing patients. I tried to get onto the second trial, but although the dr was in Australia, he only included patients from his hospital Image

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