Frustration and disbelief is legion among sufferers of MS.
It's like watching politics, all the facts are distorted to
fit the prevailing agenda. Truth and a cure are the
victims here....and real people. We require a revolution,
and even then, the powers of financial profit and dogmatic
ego will prevail for many years to come.
- Family Elder
- Posts: 2570
- Joined: Tue May 25, 2004 2:00 pm
- Location: London, ON, Canada
Excellent Paul. I've made similar comments over the years but some people accuse me of being negative and having some kind of agenda against the pharmaceutical companies and MS researchers in general!laetoli wrote:I've just fiished writing this piece on whether MS is autoimmune.
It was a lot of work so I hope it'll make some difference:
Festive greetings to you all,
It's apparent that a lot of thought went into this article.
Thank you for taking the time to write and research this. We need to make our voices heard.
I know this because I am one of these people.
Also not all animal mouse models of MS are monophasic either. In fact there is a mouse model of MS that is triggered by a virius (Theilers) and is relapsing (sound familiar?). And finally MS is considered a Th1 mediated T cell disease. Th1 stands for T helper cell type 1. Helper T cells are not directly cytotoxic meaning they do not directly cause cell damage but recruit other cells such as macrophages to perform the response via cytocines. So you will rareley find T cells witin MS lesions (unlike macrophages) but they are prevelant on the active edges.
Compare the immune system to a massive and powerful police force or army that wishes to protect the world. This army aims it's guns on a large city where it believes many dangerous spies (who have plans to destroy the entire world) are hiding in tunnels. It spends weeks blasting the city (the myelin) and reduces it to rubble. Millions of innocent civilians die yet the spies are hiding underground in a protected area (nerve ganglia) and are completely unharmed.
The army did not wish to destroy the city or kill even one civilian. A Martian visiting earth cannot understand why part of the human race appears to be destroying itself for no reason.
Herpes hides in the base of nerves in the ganglia. Herpes is a threat to the human body but I do not believe it needs to actually attack in order to come under fire from the immune system. Mistakenly, and repeatedly the immune systen attacks the nerve myelin yet herpes is not active there. Researcheres often say "herpes cannot be responsible...show me where it is attacking!". The answer is it doesn't need to attack.
However, there's lots of indirect evidence to back up the notion that the immune syatem is ruffled by herpes -though there is no concrete evidence. Firstly, DNA from herpes anti bodies is known to increase in the spinal fluid of MS sufferers during attacks by over 500%. Such DNA is unknown in the spinal fluid of non MSrs. Secondly, stress has been observed to precede both MS attacks and herpes attacks - so there is a common denominator. No other factor has been found to consistently preceed either MS attacks - or for that matter herpes attacks. Perhaps stress is ringing the sirens for the immune system to get it's guns out, because it knows a herpes attack may be on the way.
Recent reasearch confirmed that there are stong associations between various types of herpes and MS - chicken pox virus and Epstein Barre virus.
My guess is that the immune system is simply firing its guns like the policeman in South Park - it totally misses the herpes and destroys myelin instead. We are only beginning to scratch at the surface of our understanding of herpes - the "modern" illness. Herpes is so clever at disguising and cloaking itself and...I believe... misleading the immune system.
Are we sure that the tissue under attack is healthy? Where is this assumption based on? And why are the meninges involved in MS pathology?gainsbourg wrote:I don't believe MS is an "autoimmune illness" but the immune system clearly attacks healthy tissue
with MS, according to studies I have read, we seem to have high bacteria, high folic acid (made from flora), high intesinal flora, high candida, high platlets (made from flora), low uric acid. Those with MS have a high chance of dying from a UTI or pneumonia statistically. this sounds like an impaired immune system to me not an over active one. With lupus (I have studied because I have had an ANA titer of 1:1280) they have problems with low platelets, low folic acid, high uric acid. but dont listen to me cuz I am just naturally drawn to patterns and trying to figure them out, probably because schizophrenia runs so strong in my family but what you should do is what you are already doing and thats research for yourself and ask questions. I am just a hack who researches the internet.
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