"Early life exposure to normal bacteria of the GI tract (gut microbes) protects against autoimmune disease in mice, according to research published on-line in the January 17 edition of Science. The study may also have uncovered reasons why females are at greater risk of autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and lupus compared to males."
http://www.sciencedaily.com/releases/20 ... 133003.htm
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quote from the article: She adds, "We don't know yet how transfer of male gut microbes into females increases their testosterone, or how this process protects against autoimmunity.
well, I think the answer is simple and straightforward: more testosterone provides better (conditions for) cellular feeding.
see also the other topic New concept for MS.
I can’t tell you if you do the right thing, but i hope that you’re shure that your donor in in very good health. Clinics which perfom FMT screen donors stool for many pathogens.
I’ve emailed Taymount clinc to know if they heard about Clostridium perfringen type B in MS and if they could detect it in samples. They told me that their donor tests reveal the presence or absence of clostridia as a species. And that they had a communication from Professor Borody who says that FMT should deal with all the Clostridium species, not just c.diff.
The interviews will be freely available for the next 4 weeks.
part 1 :
part 2 :
Recently I had a colonoscopy. The preparation for it involves drinking a solution that clears out just about everything in the gut, so that there is not much other than water coming out of patient. On top of that I was taking antibiotics before and after the colonoscopy for unrelated issues. I'm thinking that combination cleared out all bacteria in the gut including the good and the bad. So then I started eating yogurt daily to repopulate the good bacteria.
So my before condition was;
-Bowel habits not bad but not as good as I would like.
-Had lots of trouble with gas.
-My self assessed EDSS is 6.
Its now been three weeks since the colonscopy and here is what I've noticed so far.
-Bowel habits steadily improved and are now very good.
-Gas is greatly reduced and is now what I would consider "normal"
-Haven't noticed any change in MS condition but will keep you posted, if anything happens.
cervocuit wrote:A documentary on canadian TV
part 1 :
part 2 :
Great video watched the full 2 parts.
Like one of the scientists said in the video, gut bacteria likely plays a part in MS triggering but is not the whole story. If FMT was more readily available I would definitely give it a shot... I don't know that I am brave enough to do it at home. Even though I have changed my share of baby diapers...
http://www.plosone.org/article/info%3Ad ... ne.0062815
According to this paper: “bowel preparation (for colonoscopy) does not have a lasting effect on the composition of the intestinal microbiota for the majority of subjects.”
The luminal (inside the gut) microbiome is different from the mucosal (the tissue of the gut) one. That’s why probiotics doesn’t have long lasting effect. They just pass through. There is sitting places in the gut taken early in life and perhaps difficult to extract.
That’s why Taymount clinic recommends repeated FMT (at least 15 over 3 weeks) for conditions like MS.
This is the abstracts of ECTRIMS 2014. (thanks JimmyLegs)
http://www.opus3.com/MSBoston_PressKit/ ... ournal.pdf
Posters on microbiome are at p.336-340 and one on Clostridium Perfringens specifically p.369
Gut microbiome in early pediatric multiple sclerosis: a case-control study
Not surprising !Conclusions: Preliminary findings indicate that in very early pediatric MS, gut microbiome composition is significantly altered, with enrichment for microbiota known to be associated with gastrointestinal infectious processes.
http://www.nytimes.com/2014/10/12/us/a- ... .html?_r=0
This pill goes down easier if you forget what is in it.
Inside the experimental capsule is human feces — strained, centrifuged and frozen. Taken for just two days, the preparation can cure a dangerous bacterial infection that has defied antibiotics and kills 14,000 Americans each year, researchers said Saturday.
If the results are replicated in larger trials, the pill, developed at Massachusetts General Hospital in Boston, promises an easier, cheaper and most likely safer alternative to an unpleasant procedure highlighted in both medical journals and on YouTube: fecal transplants.
http://medcitynews.com/2014/12/seres-he ... phase-iii/
Cambridge-based Seres Health, a contender in the haute field of microbiome therapeutics, just hauled in a $48 million Series C round. The startup’s developing biologics that target recurrent C. difficile infections – a real nuisance in the realm of hospital-acquired infections.
The company plans to use the funding to advance its lead candidate, SER-109, into Phase 3 clinical trials. If approved, Seres’ therapeutic line – called Ecobiotic – will be the first oral microbiome-related therapeutic that receives the regulatory go-ahead.
The Ecobiotic system works by “augmenting the biology of the microbiome,” Seres said. In September it released results from its earlier SER-109 trial, in which 29 of the study’s 30 patients were completely cured of their C. dificile infections over the course of 8 weeks. The patients received oral doses of Seres’ microbiome “spores” – that is, precursors to “good” gut bacteria that mature into disease-fighting agents. They’ve been isolated from human fecal matter, then delivered in pill-form to the patient – a promising approach given the growing bacterial resistance to antibiotics.
This all sounds like new stuff, however, I just accidentally came across a medication of similar concept, that has been made since 1917! and is still made/available today http://mutaflor.com.au. Mutaflor. It appears to only be a single strain of bacteria now, but was originally "manufactured" from the German WW1 troops poop.NHE wrote:Pills made from poop cure serious gut infections
By Marilynn Marchione, The Associated Press, 10/3/2013
It’s a gross topic, but a serious problem. Half a million Americans get Clostridium difficile, or C-diff, infections each year, and about 14,000 die. But now there is a pill full of clean microbes that doesn’t smell and can replace an invasive procedure
The interesting side to this story is how I found out about it. This medication was taken by Hitler! As an unrelated back-story, I saw it in the YouTube clip: http://www.youtube.com/watch?v=8DJr5q4Bf_s
at roughly 9:40.
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