Big multiple sclerosis breakthrough

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RyanYum
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Big multiple sclerosis breakthrough

Post by RyanYum » Sun Aug 18, 2013 7:32 pm

What treatment is this and has it even proved effective passed clinical trials ?

http://www.northwestern.edu/newscenter/ ... m_campaign

grandsons4
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Re: Big multiple sclerosis breakthrough

Post by grandsons4 » Sun Aug 18, 2013 8:22 pm

The article states that Phase II trials are yet to start, so no proof yet it works. In a somewhat related study, involving immunization with myelin, quote, "the team was able to isolate a human autoantibody, which they labeled monoclonal HIgM22. Unlike industry-synthesized antibodies, HIgM22 is a naturally occurring immunoglobulin molecule that is primitive in evolutionary terms and is the body's first and most rapid response, often referred to as the innate immune response.
HIgM22 was sequenced into a recombinant form (rHIgM22) in Dr. Pease's laboratory and was found to be as effective as its serum-derived counterpart in inducing remyelination in Theiler's virus-infected mice. The results showed that 60 to 80 percent of the animals' lesions were repaired."
"That 60 to 80 percent repaired" sounds wonderful. The article can be found at http://www.mayoclinic.org/medicalprofs/ ... u0804.html

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HarryZ
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Re: Big multiple sclerosis breakthrough

Post by HarryZ » Wed Aug 21, 2013 1:07 pm

HIgM22 was sequenced into a recombinant form (rHIgM22) in Dr. Pease's laboratory and was found to be as effective as its serum-derived counterpart in inducing remyelination in Theiler's virus-infected mice. The results showed that 60 to 80 percent of the animals' lesions were repaired.


Not to throw a damper on things but I wouldn't get too excited about any treatment that works in the that poor MS mouse. Mouse MS isn't anything like human MS and several medications that have shown promise in the mouse have not translated to any benefit in humans.

Harry

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