Brain atrophy is becoming a more reliable marker of disease progression, and is related to disabiity. Yes, there are anecdotal reports of gray matter atrophy cessation and reversal, being followed on MRI, in patients treated for CCSVI. My husband is one of them. His thalamus, brain stem and third ventricle are all "normal" now. He has MRIs over the course of the last 7 years, documenting the healing.Chemotherapies cause brain atrophy and disrupt myelin---these side effects could be contributing to "MS progression" and increasing disability---which will be blamed on the disease progression.