Bryostatin-1 as a macrolide and marine natural product has been selected as a therapeutic choice. Studies indicate that Bryostatin-1 has anti-inflammatory and antioxidant properties and decreases MMPs level and BBB damage. Furthermore, Bryostatin-1 has a neuroprotective effect and promotes neurogenesis and differentiation of oligodendrocyte progenitor stem cells as a critical step for remyelination/ myelogenesis. Based on these properties, we hypothesized here that Bryostatin-1 is an effective treatment in multiple sclerosis.
https://www.frontiersin.org/articles/10 ... 5/abstract