From Nose to Gut

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.
Post Reply
User avatar
Family Elder
Posts: 604
Joined: Sat Oct 19, 2013 10:17 am
Location: Czech Republic

From Nose to Gut

Post by Petr75 » Fri Nov 02, 2018 11:11 am

2018 Oct 8
University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK
From Nose to Gut - The Role of the Microbiome in Neurological Disease

Inflammation and neurodegeneration are key features of many chronic neurological diseases, yet the causative mechanisms underlying these processes are poorly understood. There has been mounting interest in the role of the human microbiome in modulating the inflammatory milieu of the central nervous system in health and disease. To date, most research has focussed on a gut-brain axis, with other mucosal surfaces being relatively neglected. We herein take the novel approach of comprehensively reviewing the roles of the microbiome across several key mucosal interfaces - the nose, mouth, lung, and gut - in health and in Parkinson's disease (PD), Alzheimer's disease (AD) and multiple sclerosis ..

User avatar
Family Elder
Posts: 1008
Joined: Fri Dec 18, 2009 3:00 pm
Location: Brussels

Re: From Nose to Gut

Post by Leonard » Sat Nov 03, 2018 1:37 am

quote from the abstract: The cumulative effects of dysbiosis from the nose to the gut may contribute significantly to neurological disease through a wide variety of mechanisms, including direct translocation of bacteria and their products, and modulation of systemic or central nervous system-specific immunity. unquote

Of course. Weakened immunity of the nasopharynx (CCSVI may be a contributing factor here) leads to herpes viral spreading. This may initiate a long cascade of events that eventually leads to inflammatory and -later on- to progressive MS. This is yet another publication that fully fits the skeleton at ... ml#p251748 (see e.g. step 2 viral culprit where hypoperfusion weakens the immunity of the nasopharynx)

Post Reply
  • Similar Topics
    Last post