Conflicts of Interest
Diane L. McKay is a member of the Nature’s Bounty, Co. Scientific Advisory Council. Hua J. Kern is an employee of the Nature’s Bounty, Co. Susan H. Mitmesser was an employee of the Nature’s Bounty Co. when the work was performed.
The long-term use of prescription and over-the-counter drugs can induce subclinical and clinically relevant micronutrient deficiencies, which may develop gradually over months or even years. Given the large number of medications currently available, the number of research studies examining potential drug–nutrient interactions is quite limited. A comprehensive, updated review of the potential drug–nutrient interactions with chronic use of the most often prescribed medications for commonly diagnosed conditions among the general U.S. adult population is presented. For the majority of the interactions described in this paper, more high-quality intervention trials are needed to better understand their clinical importance and potential consequences. A number of these studies have identified potential risk factors that may make certain populations more susceptible, but guidelines on how to best manage and/or prevent drug-induced nutrient inadequacies are lacking. Although widespread supplementation is not currently recommended, it is important to ensure at-risk patients reach their recommended intakes for vitamins and minerals. In conjunction with an overall healthy diet, appropriate dietary supplementation may be a practical and efficacious way to maintain or improve micronutrient status in patients at risk of deficiencies, such as those taking medications known to compromise nutritional status. The summary evidence presented in this review will help inform future research efforts and, ultimately, guide recommendations for patient care.
Table 1 Summary of potential drug–nutrient interactions and known risk factors.
http://www.mdpi.com/1999-4923/10/1/36/h ... 00036-t001
When managing drug–nutrient interactions, it is essential to consider the strength and quality of the available evidence. Even though the importance of these interactions has long been recognized, appropriately designed observational and intervention studies examining the role of dietary intervention and/or supplementation in ameliorating the effects of chronic medication use are lacking. The summary evidence presented in this review will help inform future research efforts and, ultimately, guide recommendations for patient care.
so glad i read up early, on the nexium my doc had given for my lab-verified GERD cough. i was trying to improve my nutrient status, not deplete it thanks!
also so glad i finally realized it was the bedtime/empty stomach magnesium bisglycinate that was relaxing my LES and was the root of all the GERD trouble anyway. mag form and timing change, end of problem. buh bye, nexium.
i look forward to the days when preventive is the main public-funded health care mechanism. the stitch in time approach is loooong overdue.
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
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