Search found 5583 matches

by NHE
Sat May 08, 2021 4:53 am
Forum: General Discussion
Topic: Optic pathway involvement in early MS and clinically isolated syndrome
Replies: 0
Views: 36

Optic pathway involvement in early MS and clinically isolated syndrome

Subclinical anterior optic pathway involvement in early multiple sclerosis and clinically isolated syndromes Brain. 2021 Apr 12;144(3):848-862. Optical coherence tomography (OCT) is gaining increasing relevance in the assessment of patients with multiple sclerosis. Converging evidence point to the ...
by NHE
Tue May 04, 2021 9:07 am
Forum: General Discussion
Topic: COVID jab 1 of 2
Replies: 13
Views: 253

Re: COVID jab 1 of 2

ah, nice turnaround time! unless the situation here changes, i will be waiting until the end of august for 2nd shot. in the meantime, i'll be interested to hear whether you notice major differences after this dose, compared to the first one. hopefully all goes well over there! Why is there such a l...
by NHE
Wed Apr 28, 2021 2:14 am
Forum: Sativex
Topic: GW Pharmaceuticals to be Acquired by Jazz Pharmaceuticals
Replies: 0
Views: 71

GW Pharmaceuticals to be Acquired by Jazz Pharmaceuticals

GW Pharmaceuticals Shareholders Approve Acquisition by Jazz Pharmaceuticals April 23, 2021 https://ir.gwpharm.com/news-releases/news-release-details/gw-pharmaceuticals-shareholders-approve-acquisition-jazz LONDON and DUBLIN, April 23, 2021 (GLOBE NEWSWIRE) -- GW Pharmaceuticals [maker of Sativex] p...
by NHE
Wed Apr 28, 2021 1:57 am
Forum: Parents with MS
Topic: Explaining MS to a 3 year old?
Replies: 12
Views: 7054

Re: Explaining MS to a 3 year old?

I have 3 boys - 5, 7, and 9 y/o. I've talked to them about MS only a little bit, and mostly about how it limits me at any given moment. They all know my legs are "wonky", and that sometimes I'm extra tired, but their interest seems to stop there. I've tried explaining more, but it doesn't stick yet...
by NHE
Sun Apr 25, 2021 1:11 am
Forum: Natural Approach
Topic: Wahls: Nutritional Risks of Paleolithic Diet in Progressive MS
Replies: 0
Views: 117

Wahls: Nutritional Risks of Paleolithic Diet in Progressive MS

Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet Nutrients. 2020 Jun 20;12(6):1844. Preliminary studies suggest that a modified Paleolithic diet may benefit symptoms of fatigue in progressive multiple sclerosis (MS). However, this diet ...
by NHE
Sat Apr 24, 2021 5:37 pm
Forum: General Discussion
Topic: Mechanism of Cuprizone Demyelination
Replies: 0
Views: 122

Mechanism of Cuprizone Demyelination

Many research papers now use cuprizone induced demyelination as a model for studying MS. Here's a few things we know about cuprizone. Cuprizone is a copper chelator. Cuprizone causes widespread demyelination which differs from the more punctate lesions seen in MS. The blood brain barrier remains int...
by NHE
Sat Apr 24, 2021 3:31 pm
Forum: General Discussion
Topic: The extracellular matrix
Replies: 1
Views: 127

Re: The extracellular matrix

Related research... GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis J Neurosci. 2017 Oct 11;37(41):9925-9938. Remyelination failure by oligodendrocytes contributes to the functional impairment that characterizes the demy...
by NHE
Fri Apr 23, 2021 8:30 am
Forum: General Discussion
Topic: Review: The Role of Adenosine Recptors in OPC Maturation
Replies: 0
Views: 126

Review: The Role of Adenosine Recptors in OPC Maturation

Oligodendrocyte precursor cell maturation: role of adenosine receptors Neural Regen Res. 2021 Sep;16(9):1686-1692. Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination req...
by NHE
Wed Apr 21, 2021 5:03 am
Forum: Glatopa
Topic: Glatopa equivalence to Copaxone
Replies: 0
Views: 113

Glatopa equivalence to Copaxone

Demonstration of equivalence of a generic glatiramer acetate (Glatopa™) J Neurol Sci. 2015 Dec 15;359(1-2):24-34. Glatiramer acetate (GA) has been available under the brand name Copaxone® for nearly two decades. Recently, the US Food and Drug Administration (FDA) approved the first generic GA, Glat...
by NHE
Wed Apr 21, 2021 4:37 am
Forum: Kesimpta (Ofatumumab)
Topic: Kesimpta reduces relapse-free progression
Replies: 0
Views: 132

Kesimpta reduces relapse-free progression

Kesimpta® (ofatumumab) data at AAN showed reduction in disability progression independent of relapse activity in newly diagnosed patients with RMS https://www.novartis.com/news/media-releases/kesimpta-ofatumumab-data-aan-showed-reduction-disability-progression-independent-relapse-activity-newly-dia...
by NHE
Wed Apr 21, 2021 12:57 am
Forum: Glatopa
Topic: Glatopa Prescribing Information
Replies: 0
Views: 99

Glatopa Prescribing Information

Glatopa Prescribing Information.

Galtopa is a generic glatiramer acetate for injection available in 20 mg/day and 40 mg/3x per week dosage regimens from Sandoz.

https://dailymed.nlm.nih.gov/dailymed/f ... pe=display
by NHE
Mon Apr 19, 2021 6:04 am
Forum: General Discussion
Topic: Danger mRNA covid injections
Replies: 5
Views: 269

Re: Danger mRNA covid injections

The risk of blood clots is quite small. 7,000,000 people have received the J&J vaccine. Just 6 people developed blood clots. That makes the odds less than 1 in a million. To put that into perspective, consider the following analogy. There are 100 pennies in a US dollar. $10,000 in pennies would be a...
by NHE
Sun Apr 18, 2021 8:42 pm
Forum: Ponvory (ponesimod)
Topic: Ponesimod phase III trial vs. teriflunimide
Replies: 0
Views: 118

Ponesimod phase III trial vs. teriflunimide

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial. JAMA Neurol. 2021 Mar 29;e210405. Importance: To our knowledge, the Oral Ponesimod Versus Teriflunomide In Relapsing Multiple Sclerosis (O...
by NHE
Sun Apr 18, 2021 4:42 am
Forum: General Discussion
Topic: New treatment forum: Ponvory
Replies: 0
Views: 250

New treatment forum: Ponvory

Ponvory is an oral sphingosine 1-phosphate receptor modulator indicated for the
treatment of RRMS and active SPMS.

viewforum.php?f=67
by NHE
Sun Apr 18, 2021 4:33 am
Forum: Ponvory (ponesimod)
Topic: Therapeutic Potential of Ponesimod +/- Dimethyl Fumarate in EAE
Replies: 0
Views: 113

Therapeutic Potential of Ponesimod +/- Dimethyl Fumarate in EAE

Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis Innov Clin Neurosci. 2019 Mar 1;16(3-4):22-30. Background: Despite the recent approval of new oral therapies for the treatment of multiple sclerosis (MS), a significant pe...

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