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Sjogren's syndrome can be primary or it can be secondary to RA, lupus, or MS. A recent hypothesis article describes how they can be related: http://www.frontiersin.org/Molecular_Innate_Immunity/10.3389/fimmu.2013.00091/abstract You can download the whole article as a pdf since the abstract alone doe...

S-adenosylmethionine is sometimes mentioned as a supplement that can help with suppression of inflammation but I am not a doctor so consult with your doctor before taking it. I am not familiar with how SAM gets into cells. It may be that methionine and adenosine are taken up and the cell makes SAM a...

I think MSers should read more than just the abstract to see what is new with this hypothesis. It explains how EBV (or other viruses or bacteria) can potentially lower the threshold for NETosis. And it explains some of the selectivity for autoantigens.

Autoimmune diseases may result from increased induction of NETosis in lymphocytes. In the case of MS, peptidylarginine deiminases released with NETs could be causing abnormal citrullination of myelin.

http://www.frontiersin.org/Molecular_In ... 1/abstract

Acrolein-conjugated protein is a biomarker in primary Sjogren's syndrome. SjS can occur secondary to MS, lupus and RA. (Higashi,K.,Yoshida,M.,Igarashi,A., Ito,K.,Wada,Y.,Murakami,S.,et al. (2009). Intense correlation between potein-conjugated acrolein and primary Sjögren’s syndrome. Clin. Chim. Acta...