Search found 90 matches

by TonyJegs
Wed May 16, 2007 12:24 pm
Forum: Low Dose Naltrexone
Topic: Who's on LDN?
Replies: 82
Views: 57654

LDN

MJ states for marijuana. The negative effect of stress, esp. chronic stress is underestimated all over again. To explain this it would take a hundred pages, therefore it is not possible right now. To learn more about stress start with H. Selye works, they are classic. I have no intention (and time) ...
by TonyJegs
Tue May 15, 2007 5:36 pm
Forum: General Discussion
Topic: Insulin--Could This Be the Key?
Replies: 228
Views: 59031

brain and glucose

It is nothing wrong with not being a scientist :), don’t even worry about that. Please don’t take Dr. Rosedale seriously; he is from ‘snake oil’ guys. If MD could say the statement like this: “Blood vessels constrict, glucose and insulin can't get to the tissues…” - stay away. Let me explain the sit...
by TonyJegs
Tue May 15, 2007 9:23 am
Forum: General Discussion
Topic: Insulin--Could This Be the Key?
Replies: 228
Views: 59031

insulin

Both type 1 and 2 diabetes mellitus (T1DM and T2DM) have marked defect in glucose utilization. For the brain it is a badly negative situation, because brain restoration/healing heavily depends on glucose, but glucose must be utilized, means, enter the cell, only then it will work. Even insulin pump ...
by TonyJegs
Tue May 15, 2007 9:21 am
Forum: Drug Pipeline
Topic: Oral treatments
Replies: 1
Views: 2288

money

This is a decent price, sometimes it could be up much more than 12000 euro, it depends on which institution has baked the report. Anyway, this report is of limited value for MSers, unless someone would invest more than one mil in biotech sector. You can see the core of the report; just follow the li...
by TonyJegs
Tue May 15, 2007 9:14 am
Forum: Low Dose Naltrexone
Topic: Who's on LDN?
Replies: 82
Views: 57654

LDN

It’s OK to use LDN for MS as for other chronic conditions. However it will not protect you from new lesions or stop the progression of MS, but it could slower it down, which is a good thing. Naltrexone has no direct influence on immune system, neither on other major processes. It mimics MJ by mechan...
by TonyJegs
Sat May 12, 2007 8:40 pm
Forum: General Discussion
Topic: Damage to nerve fibres
Replies: 6
Views: 2476

This article is not better or worse then most (similar) on MS theme. Old facts are presented, but you got an impression that there are the new ones. When Trapp says - “even from the very beginning of MS onset, some of the nerve fibres that cross the lesion are damaged to the point that the axons are...
by TonyJegs
Thu May 03, 2007 10:28 pm
Forum: General Discussion
Topic: Protein research - looks promising
Replies: 10
Views: 3172

So far I value only myeloid precursor cells as a likely agent with big perspective for MS; they were appeared here in one of the trends in connection with TREM-2 protein. I really wish to say more ‘brighter’ news about current or proposed drugs, but in reality their value varies from pure scum to mi...
by TonyJegs
Thu May 03, 2007 7:49 am
Forum: General Discussion
Topic: Protein research - looks promising
Replies: 10
Views: 3172

Cyclophilins

I wouldn’t call it a new discovery. Cyclophilins are around from mid 80-ties, and there are present in every single cell of the body. Last three years there were attempts made from several labs to explore possible benefits by modulating their activity. Maybe they will be ‘hot’ again for a while. I d...
by TonyJegs
Wed May 02, 2007 3:18 pm
Forum: Drug Pipeline
Topic: Laquinimod trial results
Replies: 3
Views: 2272

Re: Laquinimod trial results

...which is quite offensive really. What it should say is: STATISTICALLY INSIGNIFICANT differences in favor of the 0.6 mg dose were found for most examined secondary and exploratory MRI-based outcome measures. Trends favored the group receiving the 0.6 mg dose on measures of annual relapse rate (0....
by TonyJegs
Wed May 02, 2007 3:00 pm
Forum: General Discussion
Topic: Protein research - looks promising
Replies: 10
Views: 3172

Cyclophilins

Well, and again there is an attempt to cut the whole cell death process in pieces and claim that this particular piece is outmost important. There are two antagonistic cyclophilins, A and D. Cyclophilin A is overexpressed in cancer/tumor cell and this is the reason of their tremendous survival. If y...
by TonyJegs
Wed May 02, 2007 2:55 pm
Forum: General Discussion
Topic: Exercise and Relapses
Replies: 42
Views: 7891

Exercise is good for MS patients but take it easy to keep the inner heat down because heat might be promoting disability progression and keep it low impact because it seems that a person with MS's joints are even more succeptible to impact than a normal person. Thanks Bob, Let’s stick to this. All ...
by TonyJegs
Wed May 02, 2007 9:15 am
Forum: General Discussion
Topic: Exercise and Relapses
Replies: 42
Views: 7891

Here in Scandinavia most experts think that if one is still able to do it, any kind of aerobic exercise (including running) is able to help MSers... Here in Finland we usually go to sauna at least once a week, and it is always well heated (65-100 degrees Celcius). -finn Somehow I have an impression...
by TonyJegs
Tue May 01, 2007 8:00 am
Forum: General Discussion
Topic: Pulse steroids or estriol?
Replies: 23
Views: 6953

I think my neuro was talking about HRT with estriol only, which is bioidentical and the weakest of estrogens, whereas these studies looked at various combined therapies with other, synthetic estrogens. It doesn’t matter what kind of estrogen you use, the mechanism of action is the same (otherwise t...
by TonyJegs
Tue May 01, 2007 7:43 am
Forum: General Discussion
Topic: Exercise and Relapses
Replies: 42
Views: 7891

BELMONT, Mass., April 30 -- Exercise-associated hyponatremia, a potentially fatal condition of endurance athletes, may be brought on by suppression of renal water excretion exacerbated by excess fluid intake, investigators here reported. The deaths in 2002 of two runners who had completed the Boston...
by TonyJegs
Mon Apr 30, 2007 11:15 am
Forum: General Discussion
Topic: MS as a vascular disease
Replies: 33
Views: 10537

That is evidenced by the fact that likliehood of MS incidence is higher in close relatives of someone diagnosed with MS but expotentially higher odds are that a close relative of someone diagnosed with MS will be affected, not specifically with MS but any one of the other inflammatory diseases. If ...

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