Search found 1243 matches

by frodo
Mon Apr 22, 2019 10:23 am
Forum: General Discussion
Topic: from MSUK: Temelimab passes phase IIb
Replies: 0
Views: 2

from MSUK: Temelimab passes phase IIb

Temelimab is the only drug under research that targets a viral protein, and probably the only one that targets the underlying cause of MS. https://www.ms-uk.org/angel-ms-phase-2b-extension-study-confirms-and-extends-neuroprotective-effects-temelimab-ms ANGEL-MS Phase 2b extension study confirms and ...
by frodo
Mon Apr 22, 2019 10:19 am
Forum: General Discussion
Topic: from MSUK: FDA approves Siponimod
Replies: 0
Views: 4

from MSUK: FDA approves Siponimod

... and they have approved it for RRMS, SPMS and CIS

https://www.ms-uk.org/fda-approves-new- ... lerosis-us
by frodo
Tue Apr 16, 2019 2:11 am
Forum: General Discussion
Topic: How EBV causes MS
Replies: 0
Views: 87

How EBV causes MS

In this review, the authors propose an integrated model of EBV involvement in MS pathology Epstein-Barr Virus in Multiple Sclerosis https://www.intechopen.com/online-first/epstein-barr-virus-in-multiple-sclerosis Some excerpts: Whatever the initial cellular target, one thing is fairly well-establish...
by frodo
Tue Apr 16, 2019 12:52 am
Forum: MS Etiology and Pathogenesis
Topic: How EBV causes MS
Replies: 1
Views: 85

How EBV causes MS

In this review, the authors (Khan & Hassani) propose an integrated model of EBV involvement in MS pathology Epstein-Barr Virus in Multiple Sclerosis https://www.intechopen.com/online-first/epstein-barr-virus-in-multiple-sclerosis Some excerpts: Whatever the initial cellular target, one thing is fair...
by frodo
Sun Apr 14, 2019 10:40 am
Forum: General Discussion
Topic: 10% of MS cases are due to anti-Neurofascin autoantibody
Replies: 0
Views: 58

10% of MS cases are due to anti-Neurofascin autoantibody

Anti-Neurofascin-155 is an auto-antibody whose presence has been separated from standard MS, like it was for anti-AQP4 and anti-MOG before. This report points to that around 10% of MS cases are in fact due to anti-Neurofascin. The involvement of anti-neurofascin 155 antibodies in central and periphe...
by frodo
Sun Apr 14, 2019 10:18 am
Forum: MS Etiology and Pathogenesis
Topic: Up to 10% of MS cases are due to anti-Neurofascin autoantibody
Replies: 0
Views: 35

Up to 10% of MS cases are due to anti-Neurofascin autoantibody

Anti-Neurofascin-155 is an auto-antibody whose presence has been separated from standard MS, like it was for anti-AQP4 and anti-MOG before. This report points to that around 10% of MS cases are in fact due to anti-Neurofascin. The involvement of anti-neurofascin 155 antibodies in central and periphe...
by frodo
Mon Apr 08, 2019 4:32 am
Forum: General Discussion
Topic: Paediatric MS cases reclassified as MOG‐Ab‐demyelination
Replies: 0
Views: 47

Paediatric MS cases reclassified as MOG‐Ab‐demyelination

Get yourself tested if this is your case.

" ... many patients originally diagnosed with paediatric multiple sclerosis have been reclassified as having MOG‐Ab‐associated demyelination in recent years"

From https://onlinelibrary.wiley.com/doi/ful ... dmcn.14212
by frodo
Wed Apr 03, 2019 7:00 am
Forum: General Discussion
Topic: Andrographolides. Does anybody know what is that?
Replies: 2
Views: 70

Andrographolides. Does anybody know what is that?

It seems that there is a new therapy for progressive MS based on something called Andrographolides. Does anybody have any information? I have found only this: InnoBioscience Product Development: IB-MS for Multiple Sclerosis https://innobioscience.com/index.php?page=IBMS and, Efficacy, Safety and Tol...
by frodo
Wed Apr 03, 2019 6:56 am
Forum: MS Etiology and Pathogenesis
Topic: Report against division of MS in clinical types
Replies: 0
Views: 67

Report against division of MS in clinical types

It is interesting that this is finally getting contested, because it was introduced artificially by the pharma industry to get interferons approved. Progressive Forms of Multiple Sclerosis: Distinct Entity or Age-Dependent Phenomena. https://www.ncbi.nlm.nih.gov/pubmed/29157397 Abstract In multiple ...
by frodo
Tue Apr 02, 2019 3:05 am
Forum: MS Etiology and Pathogenesis
Topic: phd thesis about exosomes and miRNA
Replies: 1
Views: 69

phd thesis about exosomes and miRNA

A phd thesis freely avaliable about exosomes and miRNA, in case anybody is interested.

https://ses.library.usyd.edu.au/handle/2123/20208
by frodo
Sun Mar 31, 2019 11:30 am
Forum: MS Etiology and Pathogenesis
Topic: Toxicity of B Cell Products in Multiple Sclerosis
Replies: 0
Views: 43

Toxicity of B Cell Products in Multiple Sclerosis

Again, a new report of B-cells from MS patients secreting something toxic: Toxicity of Released B Cell Products in Multiple Sclerosis Abstract: https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science/article/3285-toxicity-of-released-b-cell-products-in-multiple-sclerosi...
by frodo
Thu Mar 28, 2019 5:51 am
Forum: MS Etiology and Pathogenesis
Topic: Nfl increases BEFORE damage appears on MRI
Replies: 0
Views: 76

Nfl increases BEFORE damage appears on MRI

It seems that Nfl (neurofilament light) are an not just a biomarker, but also related to the pathogenesis and measurable WEEKS BEFORE the damage has been done. Neurofilament light chain as an indicator of exacerbation prior to clinical symptoms in multiple sclerosis https://www.sciencedirect.com/sci...
by frodo
Tue Mar 26, 2019 11:04 am
Forum: General Discussion
Topic: There is an iron-responsive subtype of MS
Replies: 0
Views: 72

There is an iron-responsive subtype of MS

There are some children with MS which are iron-deficient and get better with iron supplements. Of course they do not belong to the general MS case, but this means that all the treatments for MS avoiding iron should be carefully monitored. Identification of an iron-responsive subtype in two children ...
by frodo
Tue Mar 26, 2019 5:18 am
Forum: MS Etiology and Pathogenesis
Topic: MS are several diseases. Description of an iron responsive type.
Replies: 0
Views: 76

MS are several diseases. Description of an iron responsive type.

Identification of an iron-responsive subtype in two children diagnosed with relapsing-remitting multiple sclerosis using whole exome sequencing "In MS, wide differences in age at diagnosis and disability may be indicative of subgroups of patients subject to different genetic and environmental influ...
by frodo
Sat Mar 23, 2019 4:25 am
Forum: MS Etiology and Pathogenesis
Topic: several types of alterations in NAWM and NAGM
Replies: 0
Views: 54

several types of alterations in NAWM and NAGM

Exploring metabolite profiling of patients with secondary progressive multiple sclerosis http://discovery.ucl.ac.uk/10043414/1/Monteverdi%20et%20al.pdf Synopsis Proton magnetic resonance spectroscopic imaging (MRSI) quantifies brain metabolism in vivo and has the potential of uncovering the mechanis...