Search found 1272 matches

by frodo
Mon Jun 24, 2019 12:45 am
Forum: MS Etiology and Pathogenesis
Topic: Temelimab works. HERVs clearly implicated.
Replies: 1
Views: 98

How are HERVs implicated?

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis https://www.pnas.org/content/early/2019/06/17/1901283116.short Significance There is a broad repertoire of immunomodulatory drugs that effectively treat the inflammatory aspects of relapsing mu...
by frodo
Fri Jun 21, 2019 10:54 pm
Forum: General Discussion
Topic: Micro-RNA-96 and interleukin-10 biomarkers
Replies: 0
Views: 12

Micro-RNA-96 and interleukin-10 biomarkers

Micro-RNA-96 and interleukin-10 are independent biomarkers for multiple sclerosis activity Highlights • Both IL-10 and miR-96 were overexpressed during remission compared with relapse. • No correlation was found miR-96 expression and IL-10 levels during relapse or remission phases of MS. • miR-96 c...
by frodo
Wed Jun 19, 2019 4:26 am
Forum: MS Etiology and Pathogenesis
Topic: Cortical lesions and GA
Replies: 0
Views: 27

Cortical lesions and GA

This paper is about the effects of Glatimer Acetate in MS, but they include a very deep review about the status of the research: https://www.sciencedirect.com/science/article/pii/S2211034818304942 Some excerpts: ... The components, common feature and activities of cortical lesions (CLs) have been ch...
by frodo
Wed Jun 19, 2019 4:01 am
Forum: MS Etiology and Pathogenesis
Topic: Age of cells populations in MS
Replies: 0
Views: 23

Age of cells populations in MS

Using Carbon14 the researchers can calculate the age of different cells (oligodendrocytes are myelin producing cells and OPC are oligodendrocyte precursor cells). They have reached some conclusions: https://www.nature.com/articles/s41591-019-0388-4 * About Normal appearing white matter (NAWM), which...
by frodo
Wed Jun 19, 2019 3:33 am
Forum: MS Etiology and Pathogenesis
Topic: Early MS lesions: Astrocytes involved
Replies: 0
Views: 17

Early MS lesions: Astrocytes involved

Multiple Sclerosis: Destruction and Regeneration of Astrocytes in Acute Lesions https://academic.oup.com/jnen/article/78/2/140/5272607 Abstract There are reports that astrocyte perivascular endfeet are damaged in some cases of multiple sclerosis (MS). This study was designed to determine the origin ...
by frodo
Sun Jun 02, 2019 8:03 am
Forum: MS Etiology and Pathogenesis
Topic: Real PPMS passed (again) to mice
Replies: 0
Views: 98

Real PPMS passed (again) to mice

This has been done previously (see for example posts https://www.thisisms.com/forum/viewtopic.php?f=1&t=30789 or https://www.thisisms.com/forum/viewtopic.php?f=40&t=25769) but this new result confirms again the previous results. Intrathecal Injections of PPMS Derived Antibodies Result in Motor Defic...
by frodo
Sat Jun 01, 2019 9:19 am
Forum: MS Etiology and Pathogenesis
Topic: Dawson fingers in anti-MOG disease
Replies: 0
Views: 57

Dawson fingers in anti-MOG disease

Anti-MOG disease makes around 10% of diagnosed MS patients and until now was reported only in atypical MS. Dawson fingers was considered one of the specific MS findings and one of the most reliable MRI characteristics of MS. Now MS fingers have been found in a confirmed anti-MOG patient, making even...
by frodo
Wed May 29, 2019 11:50 pm
Forum: MS Etiology and Pathogenesis
Topic: Inside-out model: supporting papers.
Replies: 5
Views: 335

abnormal myelin could be the cause

Abnormal myelin could be the cause: Down-regulation of ERMN expression in relapsing remitting multiple sclerosis. https://europepmc.org/abstract/med/31123898 Abstract Multiple Sclerosis (MS) is a chronic inflammatory disease causing demyelination and neurodegeneration in the central nervous system (...
by frodo
Tue May 28, 2019 6:29 am
Forum: MS Etiology and Pathogenesis
Topic: Personalized medicine: Prediction of natalizumab response
Replies: 0
Views: 47

Personalized medicine: Prediction of natalizumab response

Identification of CD4+ T cell biomarkers for predicting the response of patients with relapsing‑remitting multiple sclerosis to natalizumab treatment https://www.spandidos-publications.com/10.3892/mmr.2019.10283 Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervou...
by frodo
Tue May 28, 2019 6:26 am
Forum: MS Etiology and Pathogenesis
Topic: Neurofilament light as biomarker
Replies: 0
Views: 40

Neurofilament light as biomarker

Cerebrospinal fluid neurofilament light chain in multiple sclerosis and its subtypes: a meta-analysis of case–control studies https://jnnp.bmj.com/content/early/2019/05/23/jnnp-2018-319190.abstract Conclusions CSF NfL correlates with MS activity throughout the course of MS, reflecting the axonal dam...
by frodo
Tue May 28, 2019 6:24 am
Forum: MS Etiology and Pathogenesis
Topic: Review about proteomics for MS biomarkers
Replies: 0
Views: 34

Review about proteomics for MS biomarkers

Proteomic approaches to decipher mechanisms underlying pathogenesis in MS Full PDF: https://onlinelibrary.wiley.com/doi/epdf/10.1002/pmic.201800335 Conclusion Proteomic analysis of CNS tissue and body fluids is a powerful technique to identify biomarkers and therapeutic candidates. Over the past se...
by frodo
Tue May 28, 2019 6:15 am
Forum: MS Etiology and Pathogenesis
Topic: T-cells from MS patients are toxic to mice neurons
Replies: 0
Views: 52

T-cells from MS patients are toxic to mice neurons

This report points to something toxic in MS T-cells Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central neurons https://onlinelibrary.wiley.com/doi/abs/10.1111/nan.12569 Abstract The crucial step in the pathogenic events that lead to the development and th...
by frodo
Mon May 20, 2019 11:38 am
Forum: MS Etiology and Pathogenesis
Topic: Temelimab works. HERVs clearly implicated.
Replies: 1
Views: 98

Temelimab works. HERVs clearly implicated.

Efficacy and Safety of Temelimab, an Antibody Antagonist of the Human Endogenous Retrovirus Type-W env Protein, in Participants with Relapsing Remitting Multiple Sclerosis: A Double-Blind, Randomised, Placebo-Controlled Phase 2b Clinical Trial https://papers.ssrn.com/sol3/papers.cfm?abstract_id=338...
by frodo
Tue May 14, 2019 3:10 am
Forum: MS Etiology and Pathogenesis
Topic: Inside-out model: supporting papers.
Replies: 5
Views: 335

Re: Inside-out model: supporting papers.

Potential role of calcifying nanoparticles in the etiology of multiple sclerosis https://www.sciencedirect.com/science/article/pii/S030698771930221X There are currently two models to explain the development of lesions in MS. For many years it was believed that demyelination happens before axonal da...