Search found 1398 matches

by frodo
Tue Feb 11, 2020 1:50 am
Forum: MS Etiology and Pathogenesis
Topic: Quantitative Magnetisation Transfer MRI shows microscopic damage
Replies: 0
Views: 61

Quantitative Magnetisation Transfer MRI shows microscopic damage

Multiparametric qMTI Assessment and Monitoring of Normal Appearing White Matter and Classified T1 Hypointense Lesions in Relapsing-Remitting Multiple Sclerosis https://www.sciencedirect.com/science/article/pii/S1959031818302227 Background Quantitative magnetization transfer imaging (qMTI)1 is an ef...
by frodo
Thu Jan 30, 2020 6:23 am
Forum: MS Etiology and Pathogenesis
Topic: inflammatory infiltration into the cortex through the meninges underlies MS
Replies: 0
Views: 159

inflammatory infiltration into the cortex through the meninges underlies MS

A “kissing lesion”: In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis https://journals.sagepub.com/doi/abs/10.1177/1352458516683267 Background: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS...
by frodo
Tue Jan 28, 2020 6:54 am
Forum: MS Etiology and Pathogenesis
Topic: Four antioxidant biomarkers predict MS diagnosis
Replies: 0
Views: 116

Four antioxidant biomarkers predict MS diagnosis

Four antioxidant biomarkers (adiponectin, zinc, TRAP, and SH groups) and sTNFR2 showed the best diagnostic model to externally validate the MS diagnosis with sensitivity of 98.7% and specificity of 91.7% https://link.springer.com/article/10.1007/s12035-019-01856-7 Conclusion Taken together, our resu...
by frodo
Tue Jan 28, 2020 5:50 am
Forum: MS Etiology and Pathogenesis
Topic: IgG index better than oligoclonal bands
Replies: 0
Views: 100

IgG index better than oligoclonal bands

The diagnostic value of IgG index versus oligoclonal bands in cerebrospinal fluid of patients with multiple sclerosis https://journals.sagepub.com/doi/full/10.1177/2055217319901291 Background Diagnostic criteria for multiple sclerosis have been developed to guide the diagnostic process. In the late...
by frodo
Tue Jan 28, 2020 4:07 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: flow pulsatility in cerebral veins
Replies: 0
Views: 126

flow pulsatility in cerebral veins

This paper says that there must exist pulsatility in healthy cerebral veins, and that maybe a lack of it is a source of MS. https://www.biorxiv.org/content/10.1101/2020.01.24.912329v1 Abstract Phase contrast MRI has been used to investigate flow pulsatility in cerebral arteries, larger cerebral vein...
by frodo
Tue Jan 21, 2020 1:23 am
Forum: MS Etiology and Pathogenesis
Topic: Research in heterogeneity: New paper about patterns discrimination
Replies: 1
Views: 74

Previous papers about how to discriminate the patterns

Papers about tests for discriminating the patterns - September 2019 : Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry - IMG (imaging mass citometry) can discriminate the patterns. - April 2018: Tissue Markers for Acute Multiple Sclerosis Treatment Response...
by frodo
Tue Jan 21, 2020 1:18 am
Forum: MS Etiology and Pathogenesis
Topic: Research in heterogeneity: New paper about patterns discrimination
Replies: 1
Views: 74

Research in heterogeneity: New paper about patterns discrimination

New paper about discriminating the four pathological patterns: The main idea is that there are four patterns of MS (one of them, IV very rare and often ignored), and they represent different pathogenic kinds of MS. Probably the most common, pattern II, is related to EBV while the rest are not. This ...
by frodo
Mon Jan 20, 2020 9:09 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers. Response to Fingolimod can be predicted.
Replies: 1
Views: 802

Response to Fingolimod can be predicted 2: GPCRs

Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor https://www.nature.com/articles/s42003-020-0752-4 The structural plasticity of G-protein coupled receptors (GPCRs) enables the long-range transmission of conformational changes induced by specif...
by frodo
Mon Jan 20, 2020 8:18 am
Forum: MS Etiology and Pathogenesis
Topic: Two new reports about EBV
Replies: 0
Views: 95

Two new reports about EBV

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis https://www.nature.com/articles/s41598-019-55850-z Conclusion We believe this paper presents compelling new evidence from the interaction between MS risk loci and EBV DNA copy num...
by frodo
Mon Jan 20, 2020 4:40 am
Forum: MS Etiology and Pathogenesis
Topic: Reports about the CSF toxicity
Replies: 2
Views: 1118

Previous reports about the same

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model https://www.sciencedirect.com/science/article/pii/S0896841119300617 Intrathecal Injections of PPMS Derived Antibodies Result in Motor Deficits and ...
by frodo
Mon Jan 20, 2020 4:25 am
Forum: MS Etiology and Pathogenesis
Topic: Relationship between MS and type-1 diabetes
Replies: 2
Views: 88

More about MS and type-1 diabetes

Not always MS and type1 diabetes are related. But MS could be more than one disease, and maybe a subtype is related. An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes. Source: https://www.ncbi.nlm.nih.gov/pubmed/28878130 Abstract Human endogenous retroviruses (HER...
by frodo
Mon Jan 20, 2020 12:51 am
Forum: MS Etiology and Pathogenesis
Topic: Lassman review for 2019. Top four MS papers.
Replies: 0
Views: 86

Lassman review for 2019. Top four MS papers.

https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2612/2492 1. Neuronal vulnerability and multilineage diversity in multiple sclerosis (Schirmer et al 2019) The study supports the importance of meningeal inflammation with high B-lymphocyte content for cortical lesions, the heterogeneo...
by frodo
Fri Jan 17, 2020 9:31 am
Forum: MS Etiology and Pathogenesis
Topic: personalized medicine for MS
Replies: 3
Views: 197

Biomarkers for response to fingolimod

Pre-treatment T-cell subsets associate with fingolimod treatment responsiveness in multiple sclerosis https://www.nature.com/articles/s41598-019-57114-2 Abstract Biomarkers predicting fingolimod (FTY) treatment response in relapsing-remitting multiple sclerosis (RRMS) are lacking. Here, we performed...
by frodo
Fri Jan 17, 2020 6:44 am
Forum: Drug Pipeline
Topic: A University of Regina researcher believes 3 proteins may be key to treating multiple sclerosis
Replies: 1
Views: 696

Re: A University of Regina researcher believes 3 proteins may be key to treating multiple sclerosis

This mouse with multiple sclerosis could not move its hind legs or tail and had only partial movements of its front legs before beginning treatment in Josef Buttigieg's lab
It seems that they have cured EAE again ...
by frodo
Fri Jan 17, 2020 6:41 am
Forum: MS Etiology and Pathogenesis
Topic: personalized medicine for MS
Replies: 3
Views: 197

Re: personalized medicine for MS

Biomarkers for disease course: Combined Cerebrospinal Fluid Neurofilament Light Chain Protein and Chitinase-3 Like-1 Levels in Defining Disease Course and Prognosis in Multiple Sclerosis https://www.frontiersin.org/articles/10.3389/fneur.2019.01008/full Conclusions: Individual measures of CSF NFL an...