Search found 1393 matches

by frodo
Tue Jan 21, 2020 1:23 am
Forum: MS Etiology and Pathogenesis
Topic: Research in heterogeneity: New paper about patterns discrimination
Replies: 1
Views: 38

Previous papers about how to discriminate the patterns

Papers about tests for discriminating the patterns - September 2019 : Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry - IMG (imaging mass citometry) can discriminate the patterns. - April 2018: Tissue Markers for Acute Multiple Sclerosis Treatment Response...
by frodo
Tue Jan 21, 2020 1:18 am
Forum: MS Etiology and Pathogenesis
Topic: Research in heterogeneity: New paper about patterns discrimination
Replies: 1
Views: 38

Research in heterogeneity: New paper about patterns discrimination

New paper about discriminating the four pathological patterns: The main idea is that there are four patterns of MS (one of them, IV very rare and often ignored), and they represent different pathogenic kinds of MS. Probably the most common, pattern II, is related to EBV while the rest are not. This ...
by frodo
Mon Jan 20, 2020 9:09 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers. Response to Fingolimod can be predicted.
Replies: 1
Views: 756

Response to Fingolimod can be predicted 2: GPCRs

Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor https://www.nature.com/articles/s42003-020-0752-4 The structural plasticity of G-protein coupled receptors (GPCRs) enables the long-range transmission of conformational changes induced by specif...
by frodo
Mon Jan 20, 2020 8:18 am
Forum: MS Etiology and Pathogenesis
Topic: Two new reports about EBV
Replies: 0
Views: 19

Two new reports about EBV

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis https://www.nature.com/articles/s41598-019-55850-z Conclusion We believe this paper presents compelling new evidence from the interaction between MS risk loci and EBV DNA copy num...
by frodo
Mon Jan 20, 2020 4:40 am
Forum: MS Etiology and Pathogenesis
Topic: Reports about the CSF toxicity
Replies: 2
Views: 1084

Previous reports about the same

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model https://www.sciencedirect.com/science/article/pii/S0896841119300617 Intrathecal Injections of PPMS Derived Antibodies Result in Motor Deficits and ...
by frodo
Mon Jan 20, 2020 4:25 am
Forum: MS Etiology and Pathogenesis
Topic: Relationship between MS and type-1 diabetes
Replies: 2
Views: 54

More about MS and type-1 diabetes

Not always MS and type1 diabetes are related. But MS could be more than one disease, and maybe a subtype is related. An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes. Source: https://www.ncbi.nlm.nih.gov/pubmed/28878130 Abstract Human endogenous retroviruses (HER...
by frodo
Mon Jan 20, 2020 12:51 am
Forum: MS Etiology and Pathogenesis
Topic: Lassman review for 2019. Top four MS papers.
Replies: 0
Views: 18

Lassman review for 2019. Top four MS papers.

https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2612/2492 1. Neuronal vulnerability and multilineage diversity in multiple sclerosis (Schirmer et al 2019) The study supports the importance of meningeal inflammation with high B-lymphocyte content for cortical lesions, the heterogeneo...
by frodo
Fri Jan 17, 2020 9:31 am
Forum: MS Etiology and Pathogenesis
Topic: personalized medicine for MS
Replies: 3
Views: 164

Biomarkers for response to fingolimod

Pre-treatment T-cell subsets associate with fingolimod treatment responsiveness in multiple sclerosis https://www.nature.com/articles/s41598-019-57114-2 Abstract Biomarkers predicting fingolimod (FTY) treatment response in relapsing-remitting multiple sclerosis (RRMS) are lacking. Here, we performed...
by frodo
Fri Jan 17, 2020 6:44 am
Forum: Drug Pipeline
Topic: A University of Regina researcher believes 3 proteins may be key to treating multiple sclerosis
Replies: 1
Views: 609

Re: A University of Regina researcher believes 3 proteins may be key to treating multiple sclerosis

This mouse with multiple sclerosis could not move its hind legs or tail and had only partial movements of its front legs before beginning treatment in Josef Buttigieg's lab
It seems that they have cured EAE again ...
by frodo
Fri Jan 17, 2020 6:41 am
Forum: MS Etiology and Pathogenesis
Topic: personalized medicine for MS
Replies: 3
Views: 164

Re: personalized medicine for MS

Biomarkers for disease course: Combined Cerebrospinal Fluid Neurofilament Light Chain Protein and Chitinase-3 Like-1 Levels in Defining Disease Course and Prognosis in Multiple Sclerosis https://www.frontiersin.org/articles/10.3389/fneur.2019.01008/full Conclusions: Individual measures of CSF NFL an...
by frodo
Fri Jan 17, 2020 3:08 am
Forum: General Discussion
Topic: Safety vs. eficacy for some approved drugs
Replies: 0
Views: 26

Safety vs. eficacy for some approved drugs

I have found this image very telling. Watching this layout, I don't understand why not everybody is on Rituxan (nor why it is not approved) https://onlinelibrary.wiley.com/cms/attachment/7e533354-8a07-4cf3-bbc3-44abf0d5d2ab/ana24009-fig-0001-m.png Source: https://onlinelibrary.wiley.com/doi/full/10....
by frodo
Fri Jan 17, 2020 2:54 am
Forum: Drug Pipeline
Topic: Review: Eficacy vs. safety for some approved drugs
Replies: 0
Views: 30

Review: Eficacy vs. safety for some approved drugs

I have found this image very interesting. Maybe you also will:

Image

Source:

https://onlinelibrary.wiley.com/doi/ful ... /ana.24009
by frodo
Fri Jan 17, 2020 2:48 am
Forum: MS Etiology and Pathogenesis
Topic: personalized medicine for MS
Replies: 3
Views: 164

Pesonalized medication: Biomarkers for Glatimer Acetate

Correlation of serum IL‐13 and IL‐5 levels with clinical response to Glatiramer acetate in patients with multiple sclerosis https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2249.2003.02238.x SUMMARY Glatiramer acetate (GA) is effective in the treatment of Multiple Sclerosis (MS) presumably by...
by frodo
Fri Jan 17, 2020 2:42 am
Forum: MS Etiology and Pathogenesis
Topic: IGM+ MS could be different from normal MS
Replies: 1
Views: 211

IGM+ PPMS could also be different from normal PPMS

Immunoglobulin M oligoclonal bands: Biomarker of targetable inflammation in primary progressive multiple sclerosis Objective To identify a biomarker distinguishing patients who, despite a primary progressive multiple sclerosis (PPMS) clinical course, may nonetheless benefit from immune therapy. Met...
by frodo
Thu Jan 16, 2020 3:49 am
Forum: MS Etiology and Pathogenesis
Topic: Relationship between MS and type-1 diabetes
Replies: 2
Views: 54

Temelimab under study also for type-I diabetes

https://european-biotechnology.com/up-to-date/latest-news/news/geneuro-and-karolinska-institute-collaborate-in-multiple-sclerosis.html The 12-months trial, which will kick-off in QI/2020, will be led by Dr. Fredrik Piehl, head of research at the MS clinic at ASC in Stockholm, which is home to approx...