Search found 1544 matches

by frodo
Fri Jan 22, 2021 10:59 pm
Forum: MS Etiology and Pathogenesis
Topic: Nature: MRI can show biological heterogeneity
Replies: 0
Views: 41

Nature: MRI can show biological heterogeneity

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients https://www.nature.com/articles/s41598-021-81035-8 Abstract Magnetization transfer ratio (MTR) and brain volumetric imaging are (semi-)quantitative MRI markers capturing demyelination, axonal degeneration an...
by frodo
Fri Jan 22, 2021 10:52 pm
Forum: MS Etiology and Pathogenesis
Topic: Ibudilast for PPMS better than for SPMS
Replies: 0
Views: 31

Ibudilast for PPMS better than for SPMS

Response to ibudilast treatment according to progressive multiple sclerosis disease phenotype https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51251 Discussion The impetus to study ibudilast in progressive MS derived from the trial of ibudilast in relapsing MS.9 Although that study failed to d...
by frodo
Thu Jan 14, 2021 9:30 pm
Forum: General Discussion
Topic: PPMS & SPMS are qualitatively indistinguishable
Replies: 3
Views: 175

Re: PPMS & SPMS are qualitatively indistinguishable

Both progressive phases are indistinguishable by clinical analyses. In effect, there's no test that a neurologist could use to tell a PPMS patient from a SPMS patient if they were unaware of the patients' disease histories. True, but the fact is that both are indistinguishable by clinical analyses ...
by frodo
Wed Jan 13, 2021 5:31 am
Forum: MS Etiology and Pathogenesis
Topic: serum biomarkers: Phospholipids
Replies: 0
Views: 65

serum biomarkers: Phospholipids

Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis https://www.sciencedirect.com/science/article/pii/S0003986120306810?casa_token=4oKS8V2jeHcAAAAA:KQf1-bHr_MyX5geEl0GsecxqEA6NBm2qwT8hgZdeBUbBziauqzIDfuxgk1pQ9eMcBtl2YkeCPg Conclusion From this study,...
by frodo
Tue Jan 12, 2021 10:40 am
Forum: MS Etiology and Pathogenesis
Topic: Western lifestyle: Possible link to antibiotics consumption
Replies: 0
Views: 70

Western lifestyle: Possible link to antibiotics consumption

Holistic solution to an old "mystery": the global role of antibiotic consumption patterns in the spread of certain non-contagious diseases in EU countries http://www.highlightsin.org/index.php/bioscience/article/view/26 Abstract The discovery and extensive utilization of antibiotics are highly cont...
by frodo
Tue Jan 12, 2021 9:27 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Obstructive Malformations of the Internal Jugular Vein
Replies: 0
Views: 68

Obstructive Malformations of the Internal Jugular Vein

Obstructive Malformations of the Internal Jugular Vein https://link.springer.com/chapter/10.1007/978-981-15-9762-6_22 Abstract Obstructive malformations of the internal jugular veins represent a relatively new clinical problem, which as of yet has not been fully understood. In normal subjects, the ...
by frodo
Tue Jan 12, 2021 9:05 am
Forum: MS Etiology and Pathogenesis
Topic: New medical entity overlapping with MS: DAF
Replies: 0
Views: 59

New medical entity overlapping with MS: DAF

After NMO and anti-MOG, and following the non-autoimmune models of MS, it seems that there is a new entity entering the scene: Demyelination with autoimmune features (DAF): A distinct clinical entity? Results from a longitudinal cohort Abstract Central nervous system (CNS) demyelinating syndromes oc...
by frodo
Tue Jan 05, 2021 3:00 pm
Forum: MS Etiology and Pathogenesis
Topic: subtyping RRMS
Replies: 0
Views: 69

subtyping RRMS

Subtyping relapsing–remitting multiple sclerosis using structural MRI https://link.springer.com/article/10.1007/s00415-020-10376-7 Abstract Background and purpose Subtyping relapsing–remitting multiple sclerosis (RRMS) patients may help predict disease progression and triage patients for treatment....
by frodo
Tue Dec 22, 2020 12:37 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: venous diameter changes in MS
Replies: 0
Views: 69

venous diameter changes in MS

Venous Diameter Changes in Chronic Active Multiple Sclerosis Lesions https://onlinelibrary.wiley.com/doi/full/10.1111/jon.12818?casa_token=zcC_dxNgAcYAAAAA%3A01BZlBhzIAbpHmrMJLUOFFVXsaUnWMCOXgEtSYeiWfOOCrEKZqXNzBAnEZo-pcjckDPtcZna4iA7xJI CONCLUSION Our findings demonstrate venous narrowing in chroni...
by frodo
Tue Dec 22, 2020 12:35 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: vascular abnormalities in MS lesions
Replies: 2
Views: 170

vascular abnormalities in MS lesions

Revealing vascular abnormalities and measuring small vessel density in multiple sclerosis lesions using USPIO https://www.sciencedirect.com/science/article/pii/S2213158220303624 Conclusions By inducing a super-paramagnetic susceptibility in the blood using Ferumoxytol, the vascular abnormalities in...
by frodo
Tue Dec 22, 2020 12:34 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: vascular problems in MS retina
Replies: 0
Views: 63

vascular problems in MS retina

Angiography with optical coherence tomography as a biomarker in multiple sclerosis https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243236 Conclusions MS produces a decrease in retinal vascularization density in the superficial plexus of the parafoveal retina. Alterations in retin...
by frodo
Tue Dec 22, 2020 12:27 pm
Forum: MS Etiology and Pathogenesis
Topic: Dogs can smell MS
Replies: 3
Views: 623

An artificial nose can smell it too

Detecting Multiple Sclerosis via breath analysis using an eNose, a pilot study https://iopscience.iop.org/article/10.1088/1752-7163/abd080/meta?casa_token=DrOic4d8rE0AAAAA:SdVgL4zK6tj3MJk-mXlLHV8HVahQaRNGfjxUTnRfE65psVYl8vlwM62DX40Ohy4pbhxyLzNVRjGx Abstract Objective: In the present study we investi...
by frodo
Tue Dec 01, 2020 5:45 am
Forum: MS Etiology and Pathogenesis
Topic: MRZ Reaction in PPMS
Replies: 0
Views: 243

MRZ Reaction in PPMS

Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis https://www.mdpi.com/2073-4409/9/12/2543 Abstract The MRZ reaction (MRZR) comprises the three antibody indices (AIs) against measles, rubella, and varicella zoster virus, reflecting an intrat...
by frodo
Tue Dec 01, 2020 5:37 am
Forum: MS Etiology and Pathogenesis
Topic: Iron heterogeneity in MS: Patterns can be separated!!
Replies: 0
Views: 177

Iron heterogeneity in MS: Patterns can be separated!!

Iron heterogeneity in early active multiple sclerosis lesions. https://europepmc.org/article/med/33244761 Abstract OBJECTIVE : Multiple sclerosis (MS) is a heterogeneous inflammatory demyelinating disease. Iron distribution is altered in MS patients' brains suggesting iron liberation within active ...

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