Search found 1297 matches

by frodo
Fri Aug 16, 2019 10:15 am
Forum: MS Etiology and Pathogenesis
Topic: Around 13% of MS cases are of genetic origin. 12 pathogenic variants.
Replies: 1
Views: 62

New paper about the same

HLA-DRB1 differences in allelic distribution between familial and sporadic multiple sclerosis in a Hellenic cohort https://www.tandfonline.com/doi/abs/10.1080/00325481.2019.1655382 Conclusion: We propose possible HLA-DRB1 allelic distribution differences between fMS and sMS, which become more appare...
by frodo
Tue Aug 13, 2019 7:38 am
Forum: MS Etiology and Pathogenesis
Topic: Around 13% of MS cases are of genetic origin. 12 pathogenic variants.
Replies: 1
Views: 62

Around 13% of MS cases are of genetic origin. 12 pathogenic variants.

https://www.ms-uk.org/scientists-edge-closer-root-causes-multiple-sclerosis Of people diagnosed with MS, only 13% are believed to have a genetic form of the disease, but those presenting the mutations identified in this new study were estimated to have an up to 85% chance of developing MS in their l...
by frodo
Sun Aug 11, 2019 3:53 am
Forum: MS Etiology and Pathogenesis
Topic: PPMS and SPMS may be different
Replies: 0
Views: 41

PPMS and SPMS may be different

Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201948223?casa_token=sUeuM5DdkswAAAAA:4Nr2cN9LVWGPY32mhxWnv8x0oQeZ9zLZmj9q9hADkoXSLcPgZPCDGVqzjnMB4Xusj6GixtF7V-CPNg Abstract Patients with primary ...
by frodo
Sat Aug 10, 2019 10:13 am
Forum: MS Etiology and Pathogenesis
Topic: Molecular mimicry agent finally found?
Replies: 0
Views: 40

Molecular mimicry agent finally found?

Both EBNA-1 and Anoctamin-2 have been previously implicated. Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 (EBNA-1) associates with multiple sclerosis risk https://www.pnas.org/content/early/2019/08/01/1902623116.short?casa_token=-htSDkKNlgEAAAAA:kwQlBd-75XPvtdwa8cdg...
by frodo
Sat Aug 10, 2019 9:28 am
Forum: MS Etiology and Pathogenesis
Topic: Lipid profile of cerebrospinal fluid
Replies: 0
Views: 28

Lipid profile of cerebrospinal fluid

Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis https://www.nature.com/articles/s41598-019-47906-x Discussion MS is a chronic disease which is present in young adults. Nowadays diagnosis is based on four principles: (i) pattern and epidemiologic c...
by frodo
Wed Jul 31, 2019 11:49 pm
Forum: Drug Pipeline
Topic: MSRV Retrovirus, phase 2
Replies: 53
Views: 19777

Re: MSRV Retrovirus, phase 2

Maybe you are right ... There was a lot of wishful thinking from my side. But some day something has to appear, and the evolution of the discovery cannot be very different from this one.
by frodo
Wed Jul 31, 2019 11:36 pm
Forum: MS Etiology and Pathogenesis
Topic: Plasma proteins: Closer to pathogenic types discrimination
Replies: 0
Views: 71

Plasma proteins: Closer to pathogenic types discrimination

Plasma proteome in multiple sclerosis disease progression https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.771 Conclusions Our results revealed eight novel biomarkers related to clinical and radiological progression in MS. These results indicate that changes in immune system, complement pathwa...
by frodo
Wed Jul 31, 2019 11:08 pm
Forum: MS Etiology and Pathogenesis
Topic: Weird biomarker
Replies: 2
Views: 72

Re: Weird biomarker

I agree. The T-cell model is dead. At least the CD4+ classic model.
by frodo
Mon Jul 29, 2019 8:24 am
Forum: MS Etiology and Pathogenesis
Topic: CSF from MS patients damage neurons in-vitro
Replies: 1
Views: 81

Re: CSF from MS patients damage neurons in-vitro

Comments on the previous paper. A new paper in “Brain” identifies molecular mechanisms causing neuronal damage in multiple sclerosis patients with progressive clinical deterioration: https://asrc.gc.cuny.edu/headlines/2019/07/differences-in-the-cerebrospinal-fluid-of-ms-patients-may-hold-the-key-to-...
by frodo
Mon Jul 29, 2019 8:09 am
Forum: MS Etiology and Pathogenesis
Topic: Projection neurons. Whatever they are, they are involved.
Replies: 0
Views: 25

Projection neurons. Whatever they are, they are involved.

Science daily report: https://www.sciencedaily.com/releases/2019/07/190717132750.htm Scientists have discovered that a specific brain cell known as a 'projection neuron' has a central role to play in the brain changes seen in multiple sclerosis (MS). The research, published today in Nature, shows th...
by frodo
Mon Jul 29, 2019 6:34 am
Forum: MS Etiology and Pathogenesis
Topic: Weird biomarker
Replies: 2
Views: 72

Weird biomarker

Though I don't understand fully what they say, it seems that they have created a molecule with a fluorescent substrate surrounded by MBP proteins. These compound is incubated with antibodies and B cells from MS patients, and the authors report that in this case it degrades, but it does not degrade w...
by frodo
Mon Jul 29, 2019 5:06 am
Forum: MS Etiology and Pathogenesis
Topic: 1/6 of the children with MS are anti-MOG+
Replies: 0
Views: 21

1/6 of the children with MS are anti-MOG+

Prospective characterization of children positive for anti-MOG antibodies meeting Multiple Sclerosis diagnostic criteria https://n.neurology.org/content/92/15_Supplement/P4.6-042.abstract Abstract Objective: To characterize the clinical features and outcome of children meeting diagnostic criteria fo...
by frodo
Mon Jul 22, 2019 12:56 am
Forum: MS Etiology and Pathogenesis
Topic: CSF from MS patients damage neurons in-vitro
Replies: 1
Views: 81

CSF from MS patients damage neurons in-vitro

A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awz201/5531715 Abstract Multiple sclerosis is an autoimmune demyelinating disorder of the CNS, characterized by inflammatory lesions and an underlying neu...
by frodo
Thu Jul 18, 2019 3:41 am
Forum: Drug Pipeline
Topic: Temelimab safe even high dose
Replies: 0
Views: 81

Temelimab safe even high dose

A High-dose Pharmacokinetic Study of a New IgG4 Monoclonal Antibody Temelimab/GNbAC1 Antagonist of an Endogenous Retroviral Protein pHERV-W Env https://www.sciencedirect.com/science/article/pii/S0149291819302966#tbl2 Discussion We report here the results of a PK study testing very high doses of the ...
by frodo
Tue Jul 16, 2019 1:33 am
Forum: MS Etiology and Pathogenesis
Topic: An underlying process causes abnormalities in veins together with MS
Replies: 1
Views: 116

more about angiogenesis

More about the same subject. There is a whole book about it. Molecular targets of angiogenesis and anti-angiogenesis therapy https://books.google.es/books?hl=es&lr=&id=EcihDwAAQBAJ&oi=fnd&pg=PA137&dq=%22multiple+sclerosis%22&ots=Cp48tz9PQI&sig=i00rcWQkk29K5gM-CZOmvVtvWyc#v=onepage&q=%22multiple%20sc...