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Role of soluble biomarkers in multiple sclerosis https://www.sciencedirect.com/science/article/pii/S2589909025000231 Excerpts : A large cohort from the United States identified that infection with Epstein-Barr virus (EBV) increased the risk of developing MS by 30-fold, and that it was essentially n...

Metrics, distribution and dynamics of inflammatory cells in in vivo retina during multiple sclerosis https://www.medrxiv.org/content/10.1101/2025.04.16.25325926v1 Abstract Purpose : To detect in vivo retinal cellular biomarkers of inflammation in multiple sclerosis (MS), in particular immune cellul...

Microglia and Immune cells interactions https://link.springer.com/article/10.1186/s12974-024-03326-x Abstract Multiple Sclerosis (MS), a neuroinflammatory disease of the central nervous system, is one of the commonest causes of non-traumatic disability among young adults. Impaired cognition arises ...

Multiple sclerosis in 2024: evolving evidence and new hopes https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00483-6/abstract Abstract In 2024, several trends in multiple sclerosis research have extended evidence from previous years. First, the idea of the disease as a continuum—f...

The epidemiology, pathology and pathogenesis of MS: Therapeutic implications https://www.sciencedirect.com/science/article/pii/S1878747925000170 Excerpts - the revised MS-diagnostic criteria, which are currently under development, will likely remove the requirement for MS attacks (either symptomatic...

A Virus-Induced Gliopathy? In this issue of Neurology® Neuroimmunology & Neuroinflammation, Dahl et al.3 report that antibodies to membrane protein modulator of VRAC current 1 (MLC1) may be associated with MS pathology. https://www.neurology.org/doi/full/10.1212/NXI.0000000000200383 MLC1 is a m...

Oligoclonal bands and kappa free light chains https://www.sciencedirect.com/science/article/pii/S1568997225000254 Background The 2024-revised McDonald criteria for multiple sclerosis (MS) proposed to incorporate cerebrospinal fluid (CSF)-specific oligoclonal bands and kappa free light chains (KFLC)...

Optical coherence tomography and angiography in multiple sclerosis https://www.sciencedirect.com/science/article/abs/pii/S0022510X25000395 Abstract Background and objectives Anterior visual pathway involvement is common in multiple sclerosis (MS) and optical coherence tomography (OCT) can be utiliz...

Towards a biological view of multiple sclerosis from early subtle to clinical progression https://link.springer.com/article/10.1007/s00415-025-12917-4 Abstract The classification of multiple sclerosis (MS) into the two distinct phases of relapsing–remitting and progressive, including primary progre...

In-depth analysis of serum antibodies against Epstein-Barr virus lifecycle proteins, and EBNA1, ANO2, GlialCAM and CRYAB peptides https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1487523/full Results: We observed significantly elevated IgG antibody titers in EBV-positive ...

Topographical Mapping of Metabolic Abnormalities in Multiple Sclerosis https://www.sciencedirect.com/science/article/pii/S105381192500045X Conclusion In conclusion, we utilized high-resolution echo-less 3D-MRSI at 7T to investigate the topography of metabolic changes in a large brain volume of MS p...

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Autophagy-dependent ferroptosis mediates MS Warning : This is mainly about some studies on mice. Nevertheless looks promising. More about Ferroptosis at wikipedia: https://en.wikipedia.org/wiki/Ferroptosis Paper: https://www.tandfonline.com/doi/full/10.1080/15548627.2024.2419112 ABSTRACT A recent p...

Understanding Multiple Sclerosis Pathophysiology and Current Disease-Modifying Therapies https://www.imrpress.com/journal/FBL/29/11/10.31083/j.fbl2911386/htm MS is an incurable disease; however, since the introduction of interferon (IFN) in 1993, there has been a significant increase in the number o...

Barriers in Healthcare to the Use of Optical Coherence Tomography Angiography in Multiple Sclerosis https://link.springer.com/article/10.1007/s40120-024-00670-1 Retinal Vascular Changes in MS MS causes not only neuroinflammatory and neurodegenerative changes but also changes in the retinal vascular...