Search found 1191 matches

by frodo
Mon Feb 18, 2019 1:47 am
Forum: MS Etiology and Pathogenesis
Topic: Patterns thread: Selective treatment for the four patterns
Replies: 14
Views: 1890

Pattern III due to mitochondria problems

Mitochondrial defects in acute multiple sclerosis lesions. https://www.ncbi.nlm.nih.gov/pubmed/18515320 Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the CNS. The structural and immunopathological patterns of demyelination s...
by frodo
Wed Feb 13, 2019 1:50 am
Forum: General Discussion
Topic: Question: Is the same Free Light Chain and Neurofilament Light chain?
Replies: 2
Views: 72

Question: Is the same Free Light Chain and Neurofilament Light chain?

A question for the researchers around here.

Is it the same Free Light Chain and Neurofilament Light chain? I am reading a lot about them these days and I do not have clear if they are the same thing.
by frodo
Fri Feb 08, 2019 11:48 pm
Forum: MS Etiology and Pathogenesis
Topic: Vascular problems in MS
Replies: 5
Views: 674

Re: Vascular problems in MS

In my particular case I have CTOS but not CCSVI, but it seems clear that a vascular issue becomes part of the model of explanation of this complex disease. The problem with MS is that it can be several things at the same time. Given that it is a clinically defined disease, there can be several diff...
by frodo
Wed Feb 06, 2019 2:38 am
Forum: MS Etiology and Pathogenesis
Topic: The picture of demyelinating diseases gets more complicated
Replies: 0
Views: 83

The picture of demyelinating diseases gets more complicated

This is the current picture as far as the current knowledge suggest. The picture is more complex than previously thought, even if anti-neurofascin diseases are not represented: https://wol-prod-cdn.literatumonline.com/cms/attachment/c2e3cb26-4eb4-4109-b4e6-4b922db87376/cen312491-fig-0001-m.jpg There...
by frodo
Tue Feb 05, 2019 11:49 pm
Forum: MS Etiology and Pathogenesis
Topic: Immunoglobulin G analysis for diagnosis of MS
Replies: 0
Views: 44

Immunoglobulin G analysis for diagnosis of MS

High performance of cerebrospinal fluid immunoglobulin G analysis for diagnosis of multiple sclerosis https://link.springer.com/article/10.1007/s00415-019-09212-4 Background The 2017 revision of the McDonald criteria highlights the usefulness of cerebrospinal fluid (CSF) immunoglobulin G (IgG) analy...
by frodo
Tue Feb 05, 2019 2:38 am
Forum: MS Etiology and Pathogenesis
Topic: Disordered immune system and lipid metabolism in MS
Replies: 0
Views: 66

Disordered immune system and lipid metabolism in MS

A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients https://onlinelibrary.wiley.com/doi/abs/10.1111/cei.13087 Identification of autoimmune processes and introduction of new autoantigens involved in the pathogenesis of multiple sclerosis (M...
by frodo
Sun Feb 03, 2019 9:43 am
Forum: MS Etiology and Pathogenesis
Topic: maybe B-cells are not so important
Replies: 2
Views: 80

Re: maybe B-cells are not so important

I would say that for "reduction of disease activity" they mean relapses, not progresion.
by frodo
Sun Feb 03, 2019 7:49 am
Forum: MS Etiology and Pathogenesis
Topic: CSF can separate RRMS from PPMS
Replies: 0
Views: 51

CSF can separate RRMS from PPMS

Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing–Remitting Multiple Sclerosis https://www.mdpi.com/2073-4409/8/2/84 To better understand the pathophysiological differences between secondary progressive multiple sclerosis (SPMS) and relapsing-remitting multip...
by frodo
Sun Feb 03, 2019 7:46 am
Forum: MS Etiology and Pathogenesis
Topic: Inside-out model: supporting papers.
Replies: 2
Views: 99

Oligodendrocytes differences between patients and controls

Altered human oligodendrocyte heterogeneity in multiple sclerosis https://www.nature.com/articles/s41586-019-0903-2 Oligodendrocyte (OL) pathology is increasingly implicated in neurodegenerative diseases as OLs both myelinate and provide metabolic support to axons. In multiple sclerosis (MS), demye...
by frodo
Sun Feb 03, 2019 7:41 am
Forum: MS Etiology and Pathogenesis
Topic: maybe B-cells are not so important
Replies: 2
Views: 80

maybe B-cells are not so important

The success of anti-CD20 monoclonal antibodies has put the focus on CD20 B-cells, but it could be that the mechanism of action is about depleting CD20+ T-cells. Ocrelizumab Depletes CD20+ T Cells in Multiple Sclerosis Patients https://www.mdpi.com/2073-4409/8/1/12 Ocrelizumab, a humanized monoclonal...
by frodo
Sun Feb 03, 2019 1:46 am
Forum: MS Etiology and Pathogenesis
Topic: Multi-shell diffusion MRI shows early WM changes
Replies: 0
Views: 45

Multi-shell diffusion MRI shows early WM changes

It seems that multi-shell diffusion is some kind of new MRI protocol able to show the white matter early damage. Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI https://www.sciencedirect.com/science/article/pii/S221315821930049X Taken...
by frodo
Sun Feb 03, 2019 1:38 am
Forum: MS Etiology and Pathogenesis
Topic: Inside-out model: supporting papers.
Replies: 2
Views: 99

Re: Inside-out model: supporting papers.

New paper challenging the outside-in model https://www.sciencedirect.com/science/article/pii/S221315821930049X Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI We found a significant reduction in FR focally in WM lesions and widespread...
by frodo
Wed Jan 30, 2019 2:28 am
Forum: MS Etiology and Pathogenesis
Topic: Inside-out model: supporting papers.
Replies: 2
Views: 99

Inside-out model: supporting papers.

The inside-out model is an alternative theoretical model for MS that postulates that something within the neurons is the cause of the later autoimmune attack. I am collecting here some papers that support this model. Biochemically altered myelin triggers autoimmune demyelination (2018) http://www.pn...
by frodo
Wed Jan 30, 2019 1:07 am
Forum: MS Etiology and Pathogenesis
Topic: status of the research as of 2019
Replies: 0
Views: 68

status of the research as of 2019

There is a review here summarising the status of knowledge: http://www.dickyricky.com/Medicine/Papers/2018_01_11%20NEJM%20Multiple%20Sclerosis.pdf Excerpts: - Evidence from MRI and pathological assessment (biopsies and autopsies) indicates that the earliest stages of white-matter demyelination (know...