Search found 1402 matches

by frodo
Fri Apr 03, 2020 3:20 am
Forum: MS Etiology and Pathogenesis
Topic: Hints for a new astrocytic target
Replies: 0
Views: 13

Hints for a new astrocytic target

After the discovery of AQP4 and MOG it seems that there is room for a third astrocytic target (this paper talks about NMOSD but it could include atypical MS too) CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD https://jnnp.bmj.com/content/early/2020/03/...
by frodo
Fri Mar 13, 2020 4:50 am
Forum: MS Etiology and Pathogenesis
Topic: one of the mi-RNA predicts response to interferon
Replies: 0
Views: 1674

one of the mi-RNA predicts response to interferon

miR-504 expression level is increased in multiple sclerosis patients responder to interferon-beta https://www.sciencedirect.com/science/article/pii/S0165572819305776 Abstract Multiple sclerosis is immune-mediated disease of the central nervous system characterized by demyelination in axons. IFN-β is...
by frodo
Tue Feb 25, 2020 4:51 am
Forum: MS Etiology and Pathogenesis
Topic: OCBs in MS target patient-specific peptides
Replies: 0
Views: 1004

OCBs in MS target patient-specific peptides

New data speaking about different MS pathogenesis in each patient. It seems that a OCB signature has never been found because it does not exist. OCBs for each patient are different because targets are different in each patient. Oligoclonal IgG antibodies in multiple sclerosis target patient-specific...
by frodo
Tue Feb 11, 2020 1:50 am
Forum: MS Etiology and Pathogenesis
Topic: Quantitative Magnetisation Transfer MRI shows microscopic damage
Replies: 0
Views: 782

Quantitative Magnetisation Transfer MRI shows microscopic damage

Multiparametric qMTI Assessment and Monitoring of Normal Appearing White Matter and Classified T1 Hypointense Lesions in Relapsing-Remitting Multiple Sclerosis https://www.sciencedirect.com/science/article/pii/S1959031818302227 Background Quantitative magnetization transfer imaging (qMTI)1 is an ef...
by frodo
Thu Jan 30, 2020 6:23 am
Forum: MS Etiology and Pathogenesis
Topic: inflammatory infiltration into the cortex through the meninges underlies MS
Replies: 0
Views: 869

inflammatory infiltration into the cortex through the meninges underlies MS

A “kissing lesion”: In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis https://journals.sagepub.com/doi/abs/10.1177/1352458516683267 Background: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS...
by frodo
Tue Jan 28, 2020 6:54 am
Forum: MS Etiology and Pathogenesis
Topic: Four antioxidant biomarkers predict MS diagnosis
Replies: 0
Views: 907

Four antioxidant biomarkers predict MS diagnosis

Four antioxidant biomarkers (adiponectin, zinc, TRAP, and SH groups) and sTNFR2 showed the best diagnostic model to externally validate the MS diagnosis with sensitivity of 98.7% and specificity of 91.7% https://link.springer.com/article/10.1007/s12035-019-01856-7 Conclusion Taken together, our resu...
by frodo
Tue Jan 28, 2020 5:50 am
Forum: MS Etiology and Pathogenesis
Topic: IgG index better than oligoclonal bands
Replies: 0
Views: 764

IgG index better than oligoclonal bands

The diagnostic value of IgG index versus oligoclonal bands in cerebrospinal fluid of patients with multiple sclerosis https://journals.sagepub.com/doi/full/10.1177/2055217319901291 Background Diagnostic criteria for multiple sclerosis have been developed to guide the diagnostic process. In the late...
by frodo
Tue Jan 28, 2020 4:07 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: flow pulsatility in cerebral veins
Replies: 0
Views: 845

flow pulsatility in cerebral veins

This paper says that there must exist pulsatility in healthy cerebral veins, and that maybe a lack of it is a source of MS. https://www.biorxiv.org/content/10.1101/2020.01.24.912329v1 Abstract Phase contrast MRI has been used to investigate flow pulsatility in cerebral arteries, larger cerebral vein...
by frodo
Tue Jan 21, 2020 1:23 am
Forum: MS Etiology and Pathogenesis
Topic: Research in heterogeneity: New paper about patterns discrimination
Replies: 1
Views: 412

Previous papers about how to discriminate the patterns

Papers about tests for discriminating the patterns - September 2019 : Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry - IMG (imaging mass citometry) can discriminate the patterns. - April 2018: Tissue Markers for Acute Multiple Sclerosis Treatment Response...
by frodo
Tue Jan 21, 2020 1:18 am
Forum: MS Etiology and Pathogenesis
Topic: Research in heterogeneity: New paper about patterns discrimination
Replies: 1
Views: 412

Research in heterogeneity: New paper about patterns discrimination

New paper about discriminating the four pathological patterns: The main idea is that there are four patterns of MS (one of them, IV very rare and often ignored), and they represent different pathogenic kinds of MS. Probably the most common, pattern II, is related to EBV while the rest are not. This ...
by frodo
Mon Jan 20, 2020 9:09 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers. Response to Fingolimod can be predicted.
Replies: 1
Views: 1217

Response to Fingolimod can be predicted 2: GPCRs

Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor https://www.nature.com/articles/s42003-020-0752-4 The structural plasticity of G-protein coupled receptors (GPCRs) enables the long-range transmission of conformational changes induced by specif...
by frodo
Mon Jan 20, 2020 8:18 am
Forum: MS Etiology and Pathogenesis
Topic: Two new reports about EBV
Replies: 0
Views: 733

Two new reports about EBV

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis https://www.nature.com/articles/s41598-019-55850-z Conclusion We believe this paper presents compelling new evidence from the interaction between MS risk loci and EBV DNA copy num...
by frodo
Mon Jan 20, 2020 4:40 am
Forum: MS Etiology and Pathogenesis
Topic: Reports about the CSF toxicity
Replies: 2
Views: 1360

Previous reports about the same

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model https://www.sciencedirect.com/science/article/pii/S0896841119300617 Intrathecal Injections of PPMS Derived Antibodies Result in Motor Deficits and ...
by frodo
Mon Jan 20, 2020 4:25 am
Forum: MS Etiology and Pathogenesis
Topic: Relationship between MS and type-1 diabetes
Replies: 2
Views: 432

More about MS and type-1 diabetes

Not always MS and type1 diabetes are related. But MS could be more than one disease, and maybe a subtype is related. An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes. Source: https://www.ncbi.nlm.nih.gov/pubmed/28878130 Abstract Human endogenous retroviruses (HER...