Search found 1247 matches

by frodo
Wed Apr 24, 2019 11:07 pm
Forum: Drug Pipeline
Topic: 2019 murine study: Sob-AM2 for myelin repair
Replies: 2
Views: 67

Re: 2019 murine study: Sob-AM2 for myelin repair

Thanks. I think that demyelination is just the tip of an iceberg, and the cure will come from somewhere else, but anyway, its good news.
by frodo
Tue Apr 23, 2019 10:21 am
Forum: General Discussion
Topic: Selective therapies are needed. Report about reation to B-cells treatment.
Replies: 0
Views: 32

Selective therapies are needed. Report about reation to B-cells treatment.

Selective treatments are needed. Some patients respond well to B-cells depletion while for others is contraindicated. https://n.neurology.org/content/92/15_Supplement/P4.2-051.abstract Immunological phenotyping identifies a subgroup of MS patients experiencing a proinflammatory immune cell activatio...
by frodo
Tue Apr 23, 2019 3:18 am
Forum: Drug Pipeline
Topic: Siponimod approved by FDA
Replies: 0
Views: 27

Siponimod approved by FDA

Maybe we should make a new thread? FDA approves new oral drug to treat multiple sclerosis in the US https://www.ms-uk.org/fda-approves-new-oral-drug-treat-multiple-sclerosis-us The US Food and Drug Administration has approved siponimod (Mayzent) tablets to treat adults with relapsing forms of multip...
by frodo
Mon Apr 22, 2019 12:40 pm
Forum: MS Etiology and Pathogenesis
Topic: How EBV causes MS
Replies: 2
Views: 113

Re: How EBV causes MS

It would be great to have a EBV vaccine to prevent new MS cases but that would not help to the already infected people. It seems that "auto-transplant" of engineered T-cells is the way to go. These cells can control the virus. Here they explain the current research. https://www.ncbi.nlm.nih.gov/pmc/...
by frodo
Mon Apr 22, 2019 10:23 am
Forum: Drug Pipeline
Topic: from MSUK: Temelimab passes phase IIb
Replies: 0
Views: 37

from MSUK: Temelimab passes phase IIb

Temelimab is the only drug under research that targets a viral protein, and probably the only one that targets the underlying cause of MS. https://www.ms-uk.org/angel-ms-phase-2b-extension-study-confirms-and-extends-neuroprotective-effects-temelimab-ms ANGEL-MS Phase 2b extension study confirms and ...
by frodo
Mon Apr 22, 2019 10:19 am
Forum: Drug Pipeline
Topic: from MSUK: FDA approves Siponimod
Replies: 0
Views: 35

from MSUK: FDA approves Siponimod

... and they have approved it for RRMS, SPMS and CIS

https://www.ms-uk.org/fda-approves-new- ... lerosis-us
by frodo
Tue Apr 16, 2019 2:11 am
Forum: General Discussion
Topic: How EBV causes MS
Replies: 0
Views: 98

How EBV causes MS

In this review, the authors propose an integrated model of EBV involvement in MS pathology Epstein-Barr Virus in Multiple Sclerosis https://www.intechopen.com/online-first/epstein-barr-virus-in-multiple-sclerosis Some excerpts: Whatever the initial cellular target, one thing is fairly well-establish...
by frodo
Tue Apr 16, 2019 12:52 am
Forum: MS Etiology and Pathogenesis
Topic: How EBV causes MS
Replies: 2
Views: 113

How EBV causes MS

In this review, the authors (Khan & Hassani) propose an integrated model of EBV involvement in MS pathology Epstein-Barr Virus in Multiple Sclerosis https://www.intechopen.com/online-first/epstein-barr-virus-in-multiple-sclerosis Some excerpts: Whatever the initial cellular target, one thing is fair...
by frodo
Sun Apr 14, 2019 10:40 am
Forum: General Discussion
Topic: 10% of MS cases are due to anti-Neurofascin autoantibody
Replies: 0
Views: 61

10% of MS cases are due to anti-Neurofascin autoantibody

Anti-Neurofascin-155 is an auto-antibody whose presence has been separated from standard MS, like it was for anti-AQP4 and anti-MOG before. This report points to that around 10% of MS cases are in fact due to anti-Neurofascin. The involvement of anti-neurofascin 155 antibodies in central and periphe...
by frodo
Sun Apr 14, 2019 10:18 am
Forum: MS Etiology and Pathogenesis
Topic: Up to 10% of MS cases are due to anti-Neurofascin autoantibody
Replies: 0
Views: 38

Up to 10% of MS cases are due to anti-Neurofascin autoantibody

Anti-Neurofascin-155 is an auto-antibody whose presence has been separated from standard MS, like it was for anti-AQP4 and anti-MOG before. This report points to that around 10% of MS cases are in fact due to anti-Neurofascin. The involvement of anti-neurofascin 155 antibodies in central and periphe...
by frodo
Mon Apr 08, 2019 4:32 am
Forum: General Discussion
Topic: Paediatric MS cases reclassified as MOG‐Ab‐demyelination
Replies: 0
Views: 47

Paediatric MS cases reclassified as MOG‐Ab‐demyelination

Get yourself tested if this is your case.

" ... many patients originally diagnosed with paediatric multiple sclerosis have been reclassified as having MOG‐Ab‐associated demyelination in recent years"

From https://onlinelibrary.wiley.com/doi/ful ... dmcn.14212
by frodo
Wed Apr 03, 2019 7:00 am
Forum: General Discussion
Topic: Andrographolides. Does anybody know what is that?
Replies: 2
Views: 70

Andrographolides. Does anybody know what is that?

It seems that there is a new therapy for progressive MS based on something called Andrographolides. Does anybody have any information? I have found only this: InnoBioscience Product Development: IB-MS for Multiple Sclerosis https://innobioscience.com/index.php?page=IBMS and, Efficacy, Safety and Tol...
by frodo
Wed Apr 03, 2019 6:56 am
Forum: MS Etiology and Pathogenesis
Topic: Report against division of MS in clinical types
Replies: 0
Views: 67

Report against division of MS in clinical types

It is interesting that this is finally getting contested, because it was introduced artificially by the pharma industry to get interferons approved. Progressive Forms of Multiple Sclerosis: Distinct Entity or Age-Dependent Phenomena. https://www.ncbi.nlm.nih.gov/pubmed/29157397 Abstract In multiple ...
by frodo
Tue Apr 02, 2019 3:05 am
Forum: MS Etiology and Pathogenesis
Topic: phd thesis about exosomes and miRNA
Replies: 1
Views: 71

phd thesis about exosomes and miRNA

A phd thesis freely avaliable about exosomes and miRNA, in case anybody is interested.

https://ses.library.usyd.edu.au/handle/2123/20208
by frodo
Sun Mar 31, 2019 11:30 am
Forum: MS Etiology and Pathogenesis
Topic: Toxicity of B Cell Products in Multiple Sclerosis
Replies: 0
Views: 47

Toxicity of B Cell Products in Multiple Sclerosis

Again, a new report of B-cells from MS patients secreting something toxic: Toxicity of Released B Cell Products in Multiple Sclerosis Abstract: https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science/article/3285-toxicity-of-released-b-cell-products-in-multiple-sclerosi...