Search found 1513 matches

by frodo
Fri Sep 25, 2020 7:21 am
Forum: MS Etiology and Pathogenesis
Topic: EBNA1 (EBV protein) reactive to OCBs
Replies: 0
Views: 50

EBNA1 (EBV protein) reactive to OCBs

Antibodies from multiple sclerosis brain identified Epstein-Barr virus nuclear antigen 1 & 2 epitopes which are recognized by oligoclonal bands https://assets.researchsquare.com/files/rs-17090/v1/manuscript.pdf Using a phage peptide library, we screened IgG purified from a postmortem brain plaque-p...
by frodo
Tue Sep 22, 2020 11:21 am
Forum: MS Etiology and Pathogenesis
Topic: biomarkers review
Replies: 0
Views: 54

biomarkers review

Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis https://link.springer.com/article/10.1186/s12014-020-09296-5 Background Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major ch...
by frodo
Mon Sep 21, 2020 12:26 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: angiogenesis disturbed in MS
Replies: 0
Views: 86

angiogenesis disturbed in MS

Serum Anjiogenesis Factors of Neuropilin-1 andNeuropilin-2 Levels in CIS and RRMS https://assets.researchsquare.com/files/rs-67589/v1/65ad0c36-a4b8-459f-ba04-ef5ce9dd6a14.pdf Discussion In the present study, we showed Neuropilin-1 and 2 are elevated in serum from CIS and RRMS compared with healthy ...
by frodo
Thu Sep 17, 2020 6:55 am
Forum: MS Etiology and Pathogenesis
Topic: Creatine metabolic alterations in MS
Replies: 0
Views: 97

Creatine metabolic alterations in MS

Creatine and multiple sclerosis https://www.tandfonline.com/doi/abs/10.1080/1028415X.2020.1819108 ABSTRACT Multiple sclerosis (MS) is a complex and debilitating neurodegenerative disease, with unknown cause(s), unpredictable prognosis, and rather limited treatment options. MS is often accompanied b...
by frodo
Mon Sep 14, 2020 1:34 am
Forum: MS Etiology and Pathogenesis
Topic: Two molecular types of lesions via MRI
Replies: 0
Views: 95

Two molecular types of lesions via MRI

Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI https://www.sciencedirect.com/science/article/pii/S2213158220302485 Highlights : • Macroscopic and microscopic diffusion properties discriminate between MS lesion types. • The number ...
by frodo
Thu Sep 03, 2020 12:31 am
Forum: MS Etiology and Pathogenesis
Topic: Three different biopsy patterns
Replies: 0
Views: 99

Three different biopsy patterns

Different pathological processes for acute white matter lesions in multiple sclerosis https://pubmed.ncbi.nlm.nih.gov/32860370/ Abstract Introduction : Multiple sclerosis (MS) has variable clinical presentations, prognoses, pathogeneses, and pathological patterns. We conducted a pathological review...
by frodo
Tue Sep 01, 2020 5:25 am
Forum: MS Etiology and Pathogenesis
Topic: A pathogenic B cell transcriptome in active multiple sclerosis
Replies: 0
Views: 91

A pathogenic B cell transcriptome in active multiple sclerosis

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis https://www.pnas.org/content/early/2020/08/27/2008523117.short https://www.pnas.org/content/early/2020/08/27/2008523117 Abstract Central nervous system B cells have several potential roles in multiple sclerosis (MS...
by frodo
Thu Aug 27, 2020 5:43 am
Forum: MS Etiology and Pathogenesis
Topic: Mass cytometry provides insight into the role of B cells
Replies: 0
Views: 95

Mass cytometry provides insight into the role of B cells

Mass cytometry provides unprecedented insight into the role of B cells during the pathogenesis of multiple sclerosis https://www.acnr.co.uk/wp-content/uploads/2020/08/ACNR-2020-V19I3PP12to14.pdf Abstract In recent years, it has become clear that B cells play a prominent role in the pathogenesis of ...
by frodo
Tue Aug 25, 2020 8:51 am
Forum: MS Etiology and Pathogenesis
Topic: NFL shows silent relapses in PPMS cases
Replies: 0
Views: 98

NFL shows silent relapses in PPMS cases

PPMS is supposed to advance in absence of relapses. Anyway, it seems than some silent relapses can be seen via NFL CSF neurofilament light chain testing as an aid to determine treatment strategies in MS https://nn.neurology.org/content/7/6/e880 Abstract Objective To evaluate the use of CSF neurofila...
by frodo
Sun Aug 23, 2020 11:38 pm
Forum: MS Etiology and Pathogenesis
Topic: Response to b-cell depletion can be predicted
Replies: 0
Views: 82

Response to b-cell depletion can be predicted

Autoantibodies against central nervous system antigens in a subset of B cell–dominant multiple sclerosis patients https://www.pnas.org/content/early/2020/08/17/2011249117.short Significance Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). B cells play a key role...
by frodo
Thu Aug 20, 2020 11:46 pm
Forum: MS Etiology and Pathogenesis
Topic: PET differentiates pathological variants of MS
Replies: 0
Views: 56

PET differentiates pathological variants of MS

TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló’s Concentric Sclerosis https://journals.lww.com/nuclearmed/Abstract/9000/TSPO_PET_With_18F_GE_180_to_Differentiate_Variants.96521.aspx Abstract PET ta...
by frodo
Thu Aug 20, 2020 3:51 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: The perivascular space (PVS): New frontier in MS research
Replies: 0
Views: 93

The perivascular space (PVS): New frontier in MS research

It seems that the perivascular space is where all begins. This would explain the relationship between MS and vascular problems. Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions https://academic.oup.com/brain/article/143/6/1714/5836675 Abstract Mul...
by frodo
Thu Aug 20, 2020 3:03 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Letter to the editor: How do you explain these findings?
Replies: 0
Views: 69

Letter to the editor: How do you explain these findings?

Letter to the Editor (Phlebological Review 2019; 27, 1: 15-16) Anatomy of venous abnormalities in multiple sclerosis patients https://www.termedia.pl/Anatomy-of-venous-abnormalities-in-multiple-sclerosis-patients,76,40026,1,1.html Dear Editor, More than ten years have passed since the publication of...
by frodo
Thu Aug 20, 2020 2:52 am
Forum: MS Etiology and Pathogenesis
Topic: Retinal damage could be due to subclinical inflammation in optic nerve
Replies: 1
Views: 152

More about retinal damage: microstructural vascular changes

Characterization of Retinal vascular changes in Multiple Sclerosis using Adaptive Optics and OCTA https://iovs.arvojournals.org/article.aspx?articleid=2768856 Abstract Purpose : Characterize microstructural retinal vascular changes in humans MS using AO-SLO. Methods : This prospective, observationa...
by frodo
Thu Aug 20, 2020 12:25 am
Forum: MS Etiology and Pathogenesis
Topic: OCB+ and OCB- patients show different evolution
Replies: 0
Views: 55

OCB+ and OCB- patients show different evolution

It seems that OCB-negative patients show less cerebelar lesions than OCB-positives. Advanced MRI features in relapsing multiple sclerosis patients with and without CSF oligoclonal IgG bands https://www.nature.com/articles/s41598-020-70693-9 Abstract Oligoclonal IgG bands (OCB) in cerebrospinal fluid...

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