Search found 1330 matches

by frodo
Mon Oct 21, 2019 1:06 am
Forum: MS Etiology and Pathogenesis
Topic: Possibility of nasal bacteria involved in MS pathogenesis
Replies: 1
Views: 19

Possibility of nasal bacteria involved in MS pathogenesis

Bacterial transportable toxins of the nasopharyngeal microbiota in multiple sclerosis. Nose-to-brain direct https://www.sciencedirect.com/science/article/pii/S0035378719305880 Abstract Intranasal administration delivers molecules directly to the brain bypassing the blood-brain barrier. Three distin...
by frodo
Sun Oct 20, 2019 9:13 am
Forum: MS Etiology and Pathogenesis
Topic: MRS of the brain
Replies: 1
Views: 50

More about MRS, it can be used as biomarker for responses

Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a https://journals.sagepub.com/doi/full/10.1177/2055217319879952 Background Magnetic resonance spectroscopy quantitatively monitors biomarkers of neuron-myelin coupling (N-a...
by frodo
Thu Oct 17, 2019 3:01 am
Forum: MS Etiology and Pathogenesis
Topic: MS defined as a CD8+ disease
Replies: 0
Views: 40

MS defined as a CD8+ disease

This is the first time that I see some kind of concrete definition for MS, instead of defining it by a collection of symptoms and testing procedures. The following paper defines and separates several diseases by their molecular causes, instead of using the clinical courses, and they separate two kin...
by frodo
Tue Oct 15, 2019 6:28 am
Forum: MS Etiology and Pathogenesis
Topic: Herpes virus induces demyelination in rats
Replies: 0
Views: 31

Herpes virus induces demyelination in rats

Nothing to do with EAE Herpes Simplex Virus 1 induces brain inflammation and multifocal demyelination in cotton rats Sigmodon hispidus https://jvi.asm.org/content/early/2019/10/03/JVI.01161-19.abstract ABSTRACT Demyelinating CNS disorders like multiple sclerosis (MS) and acute disseminated encephalo...
by frodo
Mon Oct 14, 2019 2:26 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: The Lancet: Additional support for OCT in diagnosis
Replies: 0
Views: 42

The Lancet: Additional support for OCT in diagnosis

It seems that the new generation of biomarkers (OCB+MRZR+OCT+NFL) will allow an early an accurate diagnosis of MS (MS misdiagnosis seems quite frequent) Retinal Asymmetry in Multiple Sclerosis https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3463311 Background : The diagnosis of multiple sclerosi...
by frodo
Thu Oct 10, 2019 6:52 am
Forum: MS Etiology and Pathogenesis
Topic: MRS of the brain
Replies: 1
Views: 50

MRS of the brain

MRS (Magnetic Resonance Spectroscopy) allows to see the chemical composition of the brain. Magnetic resonance spectroscopy (MRS) is a non-invasive technique that can be used to determine the chemical composition of biological tissues in a conventional MRI scanner. https://nova.newcastle.edu.au/vital...
by frodo
Wed Oct 09, 2019 11:40 am
Forum: MS Etiology and Pathogenesis
Topic: Correlation of clinical courses and pathophysiological types
Replies: 0
Views: 28

Correlation of clinical courses and pathophysiological types

Correlation of clinical courses and pathophysiological types https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.50903 Discussion Prior histopathological studies of relapsing and progressive MS central nervous system (CNS) tissues have described pathological heterogeneity.12, 13 However, CNS tiss...
by frodo
Wed Oct 09, 2019 11:35 am
Forum: MS Etiology and Pathogenesis
Topic: MS induced by mistake
Replies: 0
Views: 32

MS induced by mistake

An unfortunate accident has shown something that could replace EAE. Multiple sclerosis associated with pembrolizumab in a patient with non-small cell lung cancer https://link.springer.com/article/10.1007/s00415-019-09562-z A 67-year-old Caucasian female patient was diagnosed with right hilar lung ad...
by frodo
Tue Oct 08, 2019 3:53 am
Forum: MS Etiology and Pathogenesis
Topic: Prodromal MS: Biomarkers
Replies: 1
Views: 673

Re: DNA methiylation signatures in MS twins

More about the same: DNA methylation signatures of a large cohort monozygotic twins clinically discordant for multiple sclerosis https://www.biorxiv.org/content/early/2018/08/01/381822 Abstract Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with a mode...
by frodo
Tue Oct 08, 2019 2:45 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Vascular malformations masquerading as demyelinating disease. May be the explanation?
Replies: 0
Views: 58

Vascular malformations masquerading as demyelinating disease. May be the explanation?

This report shows that blood flow problems can produce demyelinating lesions similar to those seen in MS. Anyway, the authors state that this kind of demyelination should be not considered MS, but just a separated demyelinating disease. Vascular malformations masquerading as demyelinating disease ht...
by frodo
Tue Oct 08, 2019 2:31 am
Forum: MS Etiology and Pathogenesis
Topic: EBV-activated CD8+ Tcells infiltrate the MS brain
Replies: 1
Views: 28

Re: EBV-activated CD8+ Tcells infiltrate the MS brain

And maybe the mechanism by which the anti-EBV Tcells cause inflammation is because they cross-react with myelin MBP: Myelin-specific CD8 T cells exacerbate brain inflammation in CNS autoimmunity https://www.jci.org/articles/view/132531 https://dm5migu4zj3pb.cloudfront.net/manuscripts/132000/132531/l...
by frodo
Tue Oct 08, 2019 2:26 am
Forum: MS Etiology and Pathogenesis
Topic: EBV-activated CD8+ Tcells infiltrate the MS brain
Replies: 1
Views: 28

EBV-activated CD8+ Tcells infiltrate the MS brain

More clues pointing to EBV as the culprit. And more evidence that EAE (a CD4+ disease) and MS have nothing to do. EBV-activated CD8+ Tcells infiltrate the MS brain and interact locally with virus infected cells. https://jvi.asm.org/content/early/2019/09/26/JVI.00980-19.abstract IMPORTANCE EBV establ...
by frodo
Tue Oct 01, 2019 4:17 am
Forum: MS Etiology and Pathogenesis
Topic: Fractional Anisotropy on DWI MRI shows microstructural damage
Replies: 0
Views: 52

Fractional Anisotropy on DWI MRI shows microstructural damage

Resolving the cognitive clinico-radiological paradox – Microstructural degeneration of fronto-striatal-thalamic loops in early active multiple sclerosis https://www.sciencedirect.com/science/article/pii/S0010945219303132 Abstract Background Associations between cognitive impairment (CI) and both gl...
by frodo
Tue Oct 01, 2019 4:07 am
Forum: MS Etiology and Pathogenesis
Topic: Myelocortical MS (MCMS)
Replies: 6
Views: 1189

Re: Myelocortical MS (MCMS)

The cortical pathology is associated to a specific CSF profile: Inflammatory intrathecal profiles and cortical damage in multiple sclerosis https://onlinelibrary.wiley.com/doi/full/10.1002/ana.25197 Abstract Objective Gray matter (GM) damage and meningeal inflammation have been associated with early...
by frodo
Tue Oct 01, 2019 3:46 am
Forum: MS Etiology and Pathogenesis
Topic: Myelocortical MS (MCMS)
Replies: 6
Views: 1189

Re: Myelocortical MS (MCMS)

Maybe related to myelocortical MS: A report about Optic-Spinal MS (OSMS) OSMS reports are old and they were found to be mostly NMO, but some cases are AQP4-negative and therefore inside MS. Thus, OSMS still exists and could be related to Myelocortical MS (MCMS) In this paper the researchers do not s...