Search found 1472 matches

by frodo
Tue Jul 14, 2020 7:41 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarker in the skin. Fibroblasts
Replies: 0
Views: 14

Biomarker in the skin. Fibroblasts

Information about fibroblasts in wikipedia: https://en.wikipedia.org/wiki/Dermal_fibroblast Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis https://pubmed.ncbi.nlm.nih.gov/32640422/ Abstract Multiple sclerosis (MS) is a central nervous sy...
by frodo
Mon Jul 13, 2020 8:50 am
Forum: MS Etiology and Pathogenesis
Topic: The picture of demyelinating diseases gets more complicated
Replies: 1
Views: 584

News about NFs: Plasma exchange for Immune-Mediated Neuropathies

Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies Abstract The inflammatory neuropathies are disabling conditions with diverse immunological mechanisms. In some, a pathogenic role for immunoglobulin G (IgG)-class autoantibodies is increasingly apprec...
by frodo
Mon Jul 13, 2020 8:26 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers: MRZ reaction distinguish MS and other disorders
Replies: 1
Views: 808

MRZ test extended: EMMRZ panel

Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis https://www.sciencedirect.com/science/article/pii/S0165572820302484 Abstract Antibody indices to MRZ are of diagnostic value in multiple sclerosis (MS). Here, we have investigated, if this panel could ...
by frodo
Mon Jul 13, 2020 8:21 am
Forum: MS Etiology and Pathogenesis
Topic: IMPORTANT: Dysfunctional RNA‐binding proteins in MS
Replies: 0
Views: 15

IMPORTANT: Dysfunctional RNA‐binding proteins in MS

As far as I know this is the first time that something like this has been reported. Neuronal RNA‐binding protein dysfunction in multiple sclerosis cortex https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51103 Abstract Objective Neurodegeneration is thought to be the primary cause of neurologica...
by frodo
Mon Jul 13, 2020 8:16 am
Forum: Drug Pipeline
Topic: Remarkable Recovery of Fulminant MS with Cyclophosphamide.
Replies: 0
Views: 28

Remarkable Recovery of Fulminant MS with Cyclophosphamide.

Remarkable Recovery of Fulminant Multiple Sclerosis After Treatment Induction with Cyclophosphamide. http://web.b.ebscohost.com/abstract?site=ehost&scope=site&jrnl=15372073&AN=144209763&h=yZyokUHB%2bE9b1GA9HYEaAdybFyyKTlBsSas8%2bjGTpnkSxj%2bVfqsIytSMS0EPbtTD2%2bHELU01PAInWy%2bz2M4K%2bw%3d%3d&crl=c&...
by frodo
Mon Jul 13, 2020 8:12 am
Forum: MS Etiology and Pathogenesis
Topic: Siponimod reduces progression with or without relapses
Replies: 0
Views: 8

Siponimod reduces progression with or without relapses

Siponimod Affects Disability Progression in Patients with Secondary Progressive Multiple Sclerosis Independent of Relapse Activity http://web.b.ebscohost.com/abstract?site=ehost&scope=site&jrnl=15372073&AN=144209775&h=25PC1G9eT1ua1b0Qqp9tAThM%2f9LRpfSsHbfL0TBUktAxNsoVil7Kc9wT28vexJOWixLCnriMq5RILN4W...
by frodo
Tue Jun 30, 2020 3:02 am
Forum: Tecfidera (BG-12, dimethyl fumarate)
Topic: Two new FDA approvals. Vumerity and Bafiertam. Tecfidera bioequivalents.
Replies: 0
Views: 31

Two new FDA approvals. Vumerity and Bafiertam. Tecfidera bioequivalents.

Two new FDA approvals. Both are bioequivalents to Dymethyl fumarate / Tecfidera. Diroximel fumerate (Vumerity). Approved by the FDA in October of 2019 https://investors.biogen.com/news-releases/news-release-details/biogen-and-alkermes-announce-fda-approval-vumeritytm-diroximel Monomethyl fumarate (B...
by frodo
Tue Jun 30, 2020 2:59 am
Forum: General Discussion
Topic: Two new FDA approvals. Vumerity and Bafiertam
Replies: 1
Views: 71

Two new FDA approvals. Vumerity and Bafiertam

Two new FDA approvals. Both are bioequivalents to Dymethyl fumarate / Tecfidera. Diroximel fumerate (Vumerity). Approved by the FDA in October of 2019 https://investors.biogen.com/news-releases/news-release-details/biogen-and-alkermes-announce-fda-approval-vumeritytm-diroximel Monomethyl fumarate (B...
by frodo
Tue Jun 30, 2020 12:37 am
Forum: MS Etiology and Pathogenesis
Topic: Highly active MS and specific treatment
Replies: 0
Views: 51

Highly active MS and specific treatment

It is not an official but regulatory agencies considered the highly active MS (HAMS) separated from the rest in their approval processes for cladribine/mavenclad (https://www.merckgroup.com/en/news/mavenclad-25-08-2017.html) Now is the same for Russia https://nnp.ima-press.net/nnp/article/view/1359 ...
by frodo
Tue Jun 30, 2020 12:05 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Cortical Grey Matter Hypoxia in MS
Replies: 0
Views: 56

Cortical Grey Matter Hypoxia in MS

Investigating the Relationship Between Cortical Grey Matter Hypoxia and Disability in Multiple Sclerosis https://prism.ucalgary.ca/handle/1880/112222 Abstract Multiple sclerosis (MS) is a progressive neurological disease characterized by inflammation and neurodegeneration. These pathological proces...
by frodo
Mon Jun 29, 2020 12:17 am
Forum: MS Etiology and Pathogenesis
Topic: Microglia are the culprits for slowly expanding lesions
Replies: 0
Views: 29

Microglia are the culprits for slowly expanding lesions

Slowly expanding lesions are suspected to be the cause of the MS progressive phase. Microglia and macrophages are cells that look similar and were previously impossible to separate, but now it is possible with a specific marker (TMEM119). This has shown that microglia and not macrophages are the cul...
by frodo
Mon Jun 29, 2020 12:11 am
Forum: MS Etiology and Pathogenesis
Topic: biomarkers review 2020 and more fingers pointing to EBV
Replies: 0
Views: 27

biomarkers review 2020 and more fingers pointing to EBV

Molecular Biomarkers in the Cerebrospinal Fluid in Multiple Sclerosis Multiple sclerosis (MS) is a chronic autoimmune disease affecting the spinal cord and brain. Detection of the disease at its initial stages is a difficult task as the causes and mechanisms of the manifestations of the disease rem...
by frodo
Thu Jun 25, 2020 1:33 am
Forum: MS Etiology and Pathogenesis
Topic: Three new genetic variants of MS
Replies: 0
Views: 40

Three new genetic variants of MS

Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01867-5 Background Neurological manifestations and the co-occurrence of multiple sclerosis (MS) have been reported in patients with au...
by frodo
Thu Jun 25, 2020 1:26 am
Forum: MS Etiology and Pathogenesis
Topic: The lancet. Open call for using NFL in diagnosis and monitoring
Replies: 0
Views: 27

The lancet. Open call for using NFL in diagnosis and monitoring

Neurofilament light in blood. What more is needed for clinical implementation? https://www.thelancet.com/pdfs/journals/ebiom/PIIS2352-3964(20)30201-2.pdf Cerebrospinalfluid (CSF) neurofilament light (NfL) is the best established fluid biomarker for neuroaxonal injury, irrespective of the underlying...
by frodo
Tue Jun 23, 2020 8:57 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Thesis: The endothelial angiopoietin-Tie signaling pathway
Replies: 0
Views: 37

Thesis: The endothelial angiopoietin-Tie signaling pathway

A new link between MS and the vascular system and angiogenesis https://helda.helsinki.fi/handle/10138/316187 Overall, this thesis provides insight into the function of Tie1 and Ang2. Our studies reveal previously unknown roles of Tie1 in lymphatic vessel development, postnatal sprouting angiogenesis...

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