Search found 1349 matches

by frodo
Wed Dec 04, 2019 12:55 am
Forum: MS Etiology and Pathogenesis
Topic: Dogs can smell MS
Replies: 1
Views: 27

MS signature in breath

And related to this, there is a MS signature in breath: https://multiple-sclerosis-research.org/2017/08/i-can-smell-you-the-breath-print-in-ms/ Exhaled Breath Markers for Non-Imaging and Non-Invasive Measures for Detection of Multiple Sclerosis. Broza YY, Har-Shai L, Jeries R, Cancilla JC, Glass-Mar...
by frodo
Wed Dec 04, 2019 12:54 am
Forum: MS Etiology and Pathogenesis
Topic: Dogs can smell MS
Replies: 1
Views: 27

Dogs can smell MS

These Dogs Know When Their Owners Are About to Have an MS Flare https://www.healthline.com/health/multiple-sclerosis/dogs-helping-with-MS#1 Health and wellness touch everyone’s life differently. Here are some stories. No matter what type of pet you have — dog, cat, bunny, or hamster — they can calm...
by frodo
Mon Dec 02, 2019 11:26 am
Forum: MS Etiology and Pathogenesis
Topic: MS linked to lipids dysregulation
Replies: 1
Views: 64

MS linked to lipids dysregulation

Before reading the paper, it is interesting also this: https://en.wikipedia.org/wiki/Eicosanoid Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction http://www.haematolo...
by frodo
Fri Nov 29, 2019 5:59 am
Forum: MS Etiology and Pathogenesis
Topic: MRZR+ MS cases are different from others
Replies: 1
Views: 141

MRZR separates MS from lupus-like with 97% confidence

Rheumatic diseases (lupus like diseases) and 60% of MS cases show antinuclear antibodies (ANA), leading to diagnosis confusion. MRZR can separate both conditions. The MRZ-Reaction and Specific Autoantibody Detection for Differentiation of ANA-Positive Multiple Sclerosis From Rheumatic Diseases With ...
by frodo
Sun Nov 24, 2019 6:03 am
Forum: MS Etiology and Pathogenesis
Topic: MS defined as a CD8+ disease
Replies: 1
Views: 187

anti-CD20 therapy is also anti-CD8+

Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis https://www.pnas.org/content/early/2019/11/19/1915309116 Significance Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. CD8+ T cells have been strongly implicated in ...
by frodo
Sun Nov 24, 2019 5:48 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Endotelin-1 involved in MS
Replies: 0
Views: 49

Endotelin-1 involved in MS

Endotelin-1 (ET-1) is a protein related to the vascular system. Modulation of cytokine-induced astrocytic endothelin-1 production as a possible new approach to the treatment of multiple sclerosis. https://www.frontiersin.org/articles/10.3389/fphar.2019.01491/abstract Results and Conclusions: ET-1 se...
by frodo
Sun Nov 24, 2019 5:39 am
Forum: General Discussion
Topic: CCSVI reloaded. Brave Dreams data re-analysed.
Replies: 1
Views: 85

CCSVI reloaded. Brave Dreams data re-analysed.

Effects of Venous Angioplasty on Cerebral Lesions in Multiple Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial https://journals.sagepub.com/doi/full/10.1177/1526602819890110 Conclusion : Expanded analysis of the Brave Dreams data that included secondar...
by frodo
Tue Nov 19, 2019 4:11 am
Forum: MS Etiology and Pathogenesis
Topic: Plasma exchange works in steroid-refractory MS
Replies: 1
Views: 26

Immunoadsorbtion better than plasma exchange

Safety and efficacy of immunoadsorption versus plasma exchange in steroid-refractory relapse of multiple sclerosis and clinically isolated syndrome: A randomised, parallel-group, controlled trial https://www.sciencedirect.com/science/article/pii/S2589537019302032 Background Plasma exchange (PE) cons...
by frodo
Tue Nov 19, 2019 4:06 am
Forum: MS Etiology and Pathogenesis
Topic: Plasma exchange works in steroid-refractory MS
Replies: 1
Views: 26

Plasma exchange works in steroid-refractory MS

Visual Outcomes of Plasma Exchange Treatment of Steroid-Refractory Optic Neuritis: A Retrospective Monocentric Analysis https://www.karger.com/Article/Abstract/504027 Introduction : In acute inflammatory optic neuritis (ON) as a typical onset of multiple sclerosis (MS), only few studies have investi...
by frodo
Thu Nov 07, 2019 7:16 am
Forum: MS Etiology and Pathogenesis
Topic: Prodromal MS: Biomarkers
Replies: 2
Views: 807

Atrophy predates MS inflammatory lesions

Normalized cerebellar white matter and gray matter volume were significantly decreased in RIS compared to healthy controls. Cerebellar volume loss in radiologically isolated syndrome https://journals.sagepub.com/doi/abs/10.1177/1352458519887346 Abstract Radiologically isolated syndrome (RIS), in whi...
by frodo
Thu Nov 07, 2019 7:11 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Response to Copaxone can be predicted
Replies: 0
Views: 86

Response to Copaxone can be predicted

This report is about a test to predict the response to Glatimer Acetate (Copaxone) https://ars.els-cdn.com/content/image/1-s2.0-S1521661619304619-ga1.jpg Abstract In this study, we investigated the role of JNK and phospho-Bcl-2 as possible biomarkers of multiple sclerosis (MS) relapse and of glatira...
by frodo
Wed Nov 06, 2019 4:27 am
Forum: General Discussion
Topic: Stem cell treatment recommended in Scotland
Replies: 0
Views: 55

Stem cell treatment recommended in Scotland

HSCT approved by NHS Scotland https://www.ms-uk.org/hsct-approved-nhs-scotland Stem cell treatment for people living with multiple sclerosis (MS) in Scotland has been recommended on the NHS for the first time. The Scottish Health Technologies Group, which provides evidence and support to NHS Scotla...
by frodo
Wed Nov 06, 2019 4:25 am
Forum: MS Etiology and Pathogenesis
Topic: personalized medicine for MS
Replies: 0
Views: 33

personalized medicine for MS

Thanks to ms-uk for the review New genetic markers may make prognosis clearer https://www.ms-uk.org/new-genetic-markers-may-make-prognosis-clearer The original paper: Early complement genes are associated with visual system degeneration in multiple sclerosis https://academic.oup.com/brain/article-ab...
by frodo
Mon Nov 04, 2019 7:26 am
Forum: MS Etiology and Pathogenesis
Topic: An underlying process causes abnormalities in veins together with MS
Replies: 2
Views: 301

Re: An underlying process causes abnormalities in veins together with MS

Central vein sign: More about vascular problems and MS. 100% sensitivity. Single Test to ARrive at Multiple Sclerosis (STAR-MS) diagnosis: A prospective pilot study assessing the accuracy of the central vein sign in predicting multiple sclerosis in cases of diagnostic uncertainty https://journals.sa...