Search found 1747 matches

by frodo
Wed Mar 06, 2024 7:35 am
Forum: General Discussion
Topic: An interesting paper about EBV and MS
Replies: 0
Views: 306

An interesting paper about EBV and MS

Ineffective control of Epstein–Barr virus infection is seen in MS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883233/ The cause of multiple sclerosis (MS) is not known. Incidence and prevalence rates differ in the various regions of the world. Migration studies have shown that age at migration h...
by frodo
Wed Mar 06, 2024 7:30 am
Forum: MS Etiology and Pathogenesis
Topic: Plasmapheresis and Immunoadsorption: How it works
Replies: 0
Views: 724

Plasmapheresis and Immunoadsorption: How it works

Miniaturized Adsorbers in Exploring the Cellular and Molecular Effects of Blood Purification https://www.mdpi.com/1422-0067/25/5/2590 Abstract Immunoadsorption (IA) has proven to be clinically effective in the treatment of steroid-refractory multiple sclerosis (MS) relapses, but its mechanism of ac...
by frodo
Tue Mar 05, 2024 12:41 pm
Forum: MS Etiology and Pathogenesis
Topic: Ineffective control of Epstein–Barr virus infection is seen in MS
Replies: 1
Views: 188

Ineffective control of Epstein–Barr virus infection is seen in MS

Ineffective control of Epstein–Barr virus infection is seen in MS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883233/ The cause of multiple sclerosis (MS) is not known. Incidence and prevalence rates differ in the various regions of the world. Migration studies have shown that age at migration h...
by frodo
Tue Mar 05, 2024 1:26 am
Forum: MS Etiology and Pathogenesis
Topic: 14 urine metabolites associated with PMS
Replies: 0
Views: 185

14 urine metabolites associated with PMS

Potential Metabolite Biomarkers of Multiple Sclerosis from Multiple Biofluids https://pubs.acs.org/doi/abs/10.1021/acschemneuro.3c00678# Abstract Multiple sclerosis (MS) is a chronic and progressive neurological disorder without a cure, but early intervention can slow disease progression and improv...
by frodo
Thu Feb 01, 2024 4:57 am
Forum: MS Etiology and Pathogenesis
Topic: Soluble factors in CSF
Replies: 1
Views: 1064

Again "soluble factors"

White matter paramagnetic rim and non-rim lesions share a periventricular gradient in multiple sclerosis https://journals.sagepub.com/doi/abs/10.1177/13524585231224681 Background : Paramagnetic rim white matter (WM) lesions (PRL) are thought to be a main driver of non-relapsing multiple sclerosis (M...
by frodo
Thu Feb 01, 2024 4:55 am
Forum: MS Etiology and Pathogenesis
Topic: Ibudilast reduces smouldering lesions
Replies: 0
Views: 462

Ibudilast reduces smouldering lesions

Slowly enlarging lesions (SEL) or "smouldering" lesions are thought to be the physiological substract of MS progression. Ibudilast reduces slowly enlarging lesions in progressive multiple sclerosis https://journals.sagepub.com/doi/abs/10.1177/13524585231224702 Background : Ibudilast has sh...
by frodo
Wed Jan 17, 2024 10:36 am
Forum: MS Etiology and Pathogenesis
Topic: Antivirals in MS: Tenofovir
Replies: 4
Views: 2988

The Answer Lies in the Details

In the Era of Antiviral Trials for MS, the Answer Lies in the Details https://www.msard-journal.com/article/S2211-0348(24)00023-3/fulltext Abstract After a seminal epidemiological study linked infection with the Epstein-Barr virus (EBV) to multiple sclerosis (MS), there is a consensus that EBV is t...
by frodo
Wed Jan 17, 2024 10:34 am
Forum: MS Etiology and Pathogenesis
Topic: Antivirals in MS: Tenofovir
Replies: 4
Views: 2988

second report

Radiologic and clinical stability in an HIV-negative MS patient after tenofovir: an updated case report https://www.sciencedirect.com/science/article/abs/pii/S2211034823008957 Introduction In 2018, members of our team published an interesting case of a patient with newly diagnosed aggressive relaps...
by frodo
Wed Jan 17, 2024 10:32 am
Forum: MS Etiology and Pathogenesis
Topic: Antivirals in MS: Tenofovir
Replies: 4
Views: 2988

Antivirals in MS: Tenofovir

Long-term MRI and clinical stability in an HIV-positive patient with multiple sclerosis on tenofovir: a case report https://www.sciencedirect.com/science/article/abs/pii/S2211034823008969 Introduction The Epstein-Barr virus (EBV) is the likely leading cause of multiple sclerosis (MS). (Bjornevik et...
by frodo
Sun Jan 14, 2024 11:51 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: obstruction of the glymphatic system
Replies: 2
Views: 1393

obstruction of the glymphatic system

The dilated veins surrounding the cord in multiple sclerosis suggest elevated pressure and obstruction of the glymphatic system https://www.sciencedirect.com/science/article/pii/S1053811924000120 Highlights • There is dilatation of the bridging veins traversing the subarachnoid space surrounding bot...
by frodo
Tue Jan 09, 2024 11:48 am
Forum: MS Etiology and Pathogenesis
Topic: Microglia in MS. Review
Replies: 1
Views: 1496

Re: Microglia in MS. Review

by frodo
Tue Nov 21, 2023 3:42 am
Forum: MS Etiology and Pathogenesis
Topic: T1-dark-rim as a sign for smouldering inflammation
Replies: 2
Views: 2922

MRI as a biomarker of the smouldering component of multiple sclerosis: time to wake up

MRI as a biomarker of the smouldering component of multiple sclerosis: time to wake up

This comment refers to the article available at https://doi.org/10.1007/s00330-023-10173-6.
by frodo
Tue Nov 21, 2023 3:41 am
Forum: MS Etiology and Pathogenesis
Topic: T1-dark-rim as a sign for smouldering inflammation
Replies: 2
Views: 2922

Magnetization transfer and diffusion tensor imaging

Longitudinal analysis of new multiple sclerosis lesions with magnetization transfer and diffusion tensor imaging https://link.springer.com/article/10.1007/s00330-023-10173-6 Abstract Objective The potential of magnetization transfer imaging (MTI) and diffusion tensor imaging (DTI) for the detection ...
by frodo
Tue Nov 21, 2023 3:38 am
Forum: MS Etiology and Pathogenesis
Topic: T1-dark-rim as a sign for smouldering inflammation
Replies: 2
Views: 2922

T1-dark-rim as a sign for smouldering inflammation

The T1-dark-rim: A novel imaging sign for detecting smoldering inflammation in multiple sclerosis https://www.researchsquare.com/article/rs-3582841/v1 Abstract Objectives : Paramagnetic rim lesions (PRLs), usually identified in susceptibility-weighted imaging (SWI), are a promising prognostic bioma...
by frodo
Sun Nov 19, 2023 8:02 am
Forum: MS Etiology and Pathogenesis
Topic: Seroreactivity 10 years befores MS onset
Replies: 0
Views: 2022

Seroreactivity 10 years befores MS onset

Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage https://jnnp.bmj.com/content/early/2023/10/06/jnnp-2023-331868.abstract Abstract Background Multiple sclerosis (MS) and presymptomatic axonal inj...

Go to advanced search