Search found 993 matches

by Leonard
Tue May 28, 2019 8:58 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 892
Views: 199244

We need a paradigm change

The medical sector does not know what is or what causes MS. But it's even worse than that. In fact, they don't know what is autoimmunity, what causes autoimmune diseases. But the health paradigm will change. If we look back at the old (= our current) health paradigm in say 2030, we will look at it i...
by Leonard
Tue May 28, 2019 8:53 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 892
Views: 199244

Re: A new concept for MS and other autoimmune diseases

The iNOS Activity During an Immune Response Controls the CNS Pathology in Experimental Autoimmune Encephalomyelitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458273/ from https://www.thisisms.com/forum/viewtopic.php?f=1&t=30982 My view: iNOS is the result of a physiological trauma induced by T c...
by Leonard
Tue May 28, 2019 8:26 am
Forum: General Discussion
Topic: MS is a Clinically Defined Disease
Replies: 1
Views: 95

Re: MS is a Clinically Defined Disease

Vesta, You are right: the medical sector does not know what is or what causes MS. But it is a lot worse than that. In fact, they ain’t got a clue what is autoimmunity, what causes autoimmune diseases. If, at some point in the future we look back at 2019, we will look at it in a way that people looke...
by Leonard
Sun May 26, 2019 7:25 am
Forum: General Discussion
Topic: iNOS
Replies: 1
Views: 85

Re: iNOS

Thank you Petr

iNOS is the result of a physiological trauma induced by T cells (inflammation).
Highly localised oxidative stress results from EBV B cell cross reaction (progression).

The full story is here: viewtopic.php?f=1&t=15188&start=885#p257234
by Leonard
Wed May 22, 2019 1:09 am
Forum: General Discussion
Topic: Epstein-Barr Virus and miRNAs
Replies: 2
Views: 146

Re: Epstein-Barr Virus and miRNAs

Thank you Petr for this link. The herpes virus causes MS, EBV is a herpes strain. The recognition of the virus at cellular level is done by SNPs. And likely via SNPs the miRNA is involved in B cell transformation. The SNPs function within the miRNA and within miRNA targets. As such, SNPs modulate mi...
by Leonard
Wed May 08, 2019 4:05 am
Forum: General Discussion
Topic: Different minerals
Replies: 2
Views: 100

Re: Different minerals

A short of minerals could derail anti-oxidant working, but then only in the progressive phase. And one would need to be clearly deficient as well to see an effect. The oxidative stress cycle only starts gradually after the inflammatory cycle(s). But here they look more to the onset and thus inflamma...
by Leonard
Sat May 04, 2019 4:34 am
Forum: General Discussion
Topic: Focus on the gut-brain axis
Replies: 27
Views: 2328

Re: Focus on the gut-brain axis

2018 Nov 6 UCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, California Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria PMC Article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222044/ ....
by Leonard
Sun Apr 28, 2019 1:40 am
Forum: General Discussion
Topic: The changing concepts
Replies: 1
Views: 151

Re: The changing concepts

exactly, the concept needs to change. and exactly, oxidative stress, mitochondrial failure and hypoxia are important factors. for more information about what's really underlying MS, see for instance my thinking on https://www.thisisms.com/forum/general-discussion-f1/topic15188-825.html#p251748 and h...
by Leonard
Thu Apr 04, 2019 11:41 pm
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 892
Views: 199244

Autoimmunity and our society

Autoimmunity and our society [later amendments and additions in italics] Our cells have very small deviations, called Single Nucleotide Polymorphisms (SNPs) which have always been considered to be irrelevant. But they are not, they are very important as they are gatekeepers that signal whether a cel...
by Leonard
Thu Apr 04, 2019 11:36 pm
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 892
Views: 199244

Re: A new concept for MS and other autoimmune diseases

Elliot, Vesta, thank you. I agree with you that we must take care of ourselves. That is what I try to do as well. But besides what we do in our own private sphere, public intervention and funding would seem logical because there is not a patentable molecule involved here, the underlying thinking (se...
by Leonard
Sun Feb 10, 2019 5:54 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 892
Views: 199244

Re: A new concept and treatment options for MS

On the Internet we find a mountain of medical publications, often in the open literature. Most of these publications consider the problem "in their own domain" resulting in an incomplete picture. But if we bring it all together, we can see a huge breakthrough on the horizon built on a series of inte...
by Leonard
Sun Feb 10, 2019 5:42 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 892
Views: 199244

Re: A new concept and treatment options for MS

We have seen that the oxidative stress cycle originates from a herpes viral infection. As the following article suggests, it may now well be that herpes viral spreading is facilitated by oxidative stress. That is bad because it would be a further stimulous for the vicious cycle, a sort of self-perpe...
by Leonard
Fri Feb 08, 2019 5:39 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 892
Views: 199244

Re: A new concept and treatment options for MS

https://www.ncbi.nlm.nih.gov/pubmed/29457866 on Epigenetic effects of metformin: From molecular mechanisms to clinical implications If we assume for a moment that all autoimmune diseases originate from the same underlying mechanism (i.e. B cells that cross react with viral epitopes after epigenetic ...
by Leonard
Mon Feb 04, 2019 5:57 am
Forum: General Discussion
Topic: A new concept for MS and other autoimmune diseases
Replies: 892
Views: 199244

Re: A new concept and treatment options for MS

From the other thread on MTA and MS https://www.thisisms.com/forum/viewtopic.php?f=1&t=3628 and in particular https://www.thisisms.com/forum/viewtopic.php?f=1&t=3628#p256597 If the methylation cycle is restored (normally should be done by restoring the gut function but here is it is done by oral adm...
by Leonard
Mon Feb 04, 2019 5:50 am
Forum: General Discussion
Topic: MTA and MS
Replies: 5
Views: 1898

Re: MTA and MS

If the methylation cycle is restored (normally should be done by restoring the gut function but here is it is done by oral administration), cellular expression will be down and the autoimmune reaction will come to a halt. I don't exclude the possibility that some remyelination may occur at that poin...