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I've always been suspicious about the link between lesions and progression. I was diagnosed 5 years ago by "one of the best neuros" in the world with a negative lumbar puncture, negative vep and no physical or mental symptoms - purely on an MRI following a gym accident. They pushed the dmd...

I have the same question... i also have a negitive LP & evoked potentials, i had a mild attack of some kind 1.5 years ago (just a little numbness in my hand and leg) that went away. I have had no other symproms since. At the time i had a MRI that showed 9 lesions. I have had 2 more MRS's since ...