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Cognitive dysfunction

Last post by Petr75 « Sat Sep 26, 2020 10:58 pm
Posted in General Discussion

by Petr75 » Sat Sep 26, 2020 10:58 pm » in General Discussion

2020 Aug 28
Department of Radiology, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Department of Radiology,...

0 Replies

23 Views

Last post by Petr75
Sat Sep 26, 2020 10:58 pm
Lithium

Last post by Petr75 « Sat Sep 26, 2020 11:34 am
Posted in General Discussion

by Petr75 » Sat Sep 26, 2020 11:34 am » in General Discussion

2020 Aug 26
Clinica Psichiatrica-Dipartimento di Scienze Mediche Chirurgiche e Sperimentali, Università degli Studi di Sassari-AOU Sassari, Sassari,...

0 Replies

28 Views

Last post by Petr75
Sat Sep 26, 2020 11:34 am
Signal regulatory protein gamma (SIRPγ)

Last post by Petr75 « Sat Sep 26, 2020 8:20 am
Posted in General Discussion

by Petr75 » Sat Sep 26, 2020 8:20 am » in General Discussion

2020 Aug 27
Department of Pathology, University of Iowa Health Care, Iowa City, Iowa
Altered expression of SIRPγ on the T-cells of relapsing...

0 Replies

37 Views

Last post by Petr75
Sat Sep 26, 2020 8:20 am
EBNA1 (EBV protein) reactive to OCBs

Last post by frodo « Fri Sep 25, 2020 7:21 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Sep 25, 2020 7:21 am » in MS Etiology and Pathogenesis

Antibodies from multiple sclerosis brain identified Epstein-Barr virus nuclear antigen 1 & 2 epitopes which are recognized by oligoclonal bands...

0 Replies

48 Views

Last post by frodo
Fri Sep 25, 2020 7:21 am
biomarkers review

Last post by frodo « Tue Sep 22, 2020 11:21 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Sep 22, 2020 11:21 am » in MS Etiology and Pathogenesis

Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis

Background

Verification of...

0 Replies

51 Views

Last post by frodo
Tue Sep 22, 2020 11:21 am
CNS disorders market

Last post by jimmylegs « Mon Sep 21, 2020 5:19 am
Posted in General Discussion

by jimmylegs » Mon Sep 21, 2020 5:19 am » in General Discussion

A view into the central nervous system disorders market (2020)

Top products
Therapies for multiple sclerosis (MS) accounted for 7 of the top 15...

0 Replies

91 Views

Last post by jimmylegs
Mon Sep 21, 2020 5:19 am
angiogenesis disturbed in MS

Last post by frodo « Mon Sep 21, 2020 12:26 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Mon Sep 21, 2020 12:26 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Serum Anjiogenesis Factors of Neuropilin-1 andNeuropilin-2 Levels in CIS and RRMS

Discussion

In the present study, we showed Neuropilin-1 and...

0 Replies

80 Views

Last post by frodo
Mon Sep 21, 2020 12:26 am
Therapies tageting B cells

Last post by NHE « Sun Sep 20, 2020 2:53 pm
Posted in General Discussion

by NHE » Sun Sep 20, 2020 2:53 pm » in General Discussion

Therapies for multiple sclerosis targeting B cells
Croat Med J. 2019 Apr 30;60(2):87-98.

Increasing evidence suggests that B cells contribute...

0 Replies

106 Views

Last post by NHE
Sun Sep 20, 2020 2:53 pm
Molecular Biomarkers

Last post by Petr75 « Sun Sep 20, 2020 1:26 am
Posted in General Discussion

by Petr75 » Sun Sep 20, 2020 1:26 am » in General Discussion

2020 Aug 21
Precision Rheumatology INC, 2050 South Euclid Street, Anaheim
Molecular Biomarkers in Multiple Sclerosis and Its Related Disorders: A...

0 Replies

89 Views

Last post by Petr75
Sun Sep 20, 2020 1:26 am
Immune signatures

Last post by Petr75 « Fri Sep 18, 2020 11:03 am
Posted in General Discussion

by Petr75 » Fri Sep 18, 2020 11:03 am » in General Discussion

2020 Sep 1
Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians Universität München, Munich, Germany...

0 Replies

106 Views

Last post by Petr75
Fri Sep 18, 2020 11:03 am
Diarylheptanoids 6b and 6c

Last post by Petr75 « Fri Sep 18, 2020 10:31 am
Posted in General Discussion

by Petr75 » Fri Sep 18, 2020 10:31 am » in General Discussion

2020 Sep 3
Department of Science, University of Basilicata, Via dell'Ateneo Luca, Potenza, Italy
New synthesized polyoxygenated diarylheptanoids...

0 Replies

103 Views

Last post by Petr75
Fri Sep 18, 2020 10:31 am
Creatine metabolic alterations in MS

Last post by frodo « Thu Sep 17, 2020 6:55 am
Posted in MS Etiology and Pathogenesis

by frodo » Thu Sep 17, 2020 6:55 am » in MS Etiology and Pathogenesis

Creatine and multiple sclerosis

ABSTRACT

Multiple sclerosis (MS) is a complex and debilitating neurodegenerative disease, with unknown...

0 Replies

94 Views

Last post by frodo
Thu Sep 17, 2020 6:55 am
Voice Treatment

Last post by Petr75 « Tue Sep 15, 2020 10:19 am
Posted in General Discussion

by Petr75 » Tue Sep 15, 2020 10:19 am » in General Discussion

2020 Aug 18
IRCSS Fondazione Don Carlo Gnocchi, Milano, Italy
Effects of Intensive Voice Treatment (The Lee Silverman Voice Treatment ) in Subjects...

0 Replies

104 Views

Last post by Petr75
Tue Sep 15, 2020 10:19 am
Dealing with wildfire smoke

Last post by NHE « Mon Sep 14, 2020 3:28 am
Posted in Daily Life

by NHE » Mon Sep 14, 2020 3:28 am » in Daily Life

There are lots of wildfires on the West Coast. These have filled the air with smoke and toxic particulate matter. In some cites, such as Portland,...

0 Replies

91 Views

Last post by NHE
Mon Sep 14, 2020 3:28 am
Two molecular types of lesions via MRI

Last post by frodo « Mon Sep 14, 2020 1:34 am
Posted in MS Etiology and Pathogenesis

by frodo » Mon Sep 14, 2020 1:34 am » in MS Etiology and Pathogenesis

Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI

Highlights :

• Macroscopic...

0 Replies

93 Views

Last post by frodo
Mon Sep 14, 2020 1:34 am
Gratitude

Last post by Petr75 « Sun Sep 13, 2020 1:19 am
Posted in General Discussion

by Petr75 » Sun Sep 13, 2020 1:19 am » in General Discussion

2020 Aug
Department of Clinical Psychology, Seattle Pacific University
Gratitude is positively associated with quality of life in multiple sclerosis...

0 Replies

136 Views

Last post by Petr75
Sun Sep 13, 2020 1:19 am
CBD acts as a sigma-1 antagonist

Last post by NHE « Sat Sep 12, 2020 6:46 am
Posted in Medical Marijuana

by NHE » Sat Sep 12, 2020 6:46 am » in Medical Marijuana

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
Mol Brain. 2018...

0 Replies

88 Views

Last post by NHE
Sat Sep 12, 2020 6:46 am
Impact of Diet on MS Symptoms

Last post by TheMSCookbook « Mon Sep 07, 2020 8:30 pm
Posted in Diet

by TheMSCookbook » Mon Sep 07, 2020 8:30 pm » in Diet

The MS Diet and The MS Cookbook is an amazing resource for people with MS or people just looking for a healthy diet to follow. It is so hard for...

0 Replies

106 Views

Last post by TheMSCookbook
Mon Sep 07, 2020 8:30 pm
Mechanotherapy

Last post by Petr75 « Mon Sep 07, 2020 6:33 am
Posted in General Discussion

by Petr75 » Mon Sep 07, 2020 6:33 am » in General Discussion

2020
Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia
Robotic mechanotherapy in patients with multiple sclerosis with...

0 Replies

138 Views

Last post by Petr75
Mon Sep 07, 2020 6:33 am
Transplanted glial cells repair MS damage in mice

Last post by NHE « Sun Sep 06, 2020 12:39 am
Posted in General Discussion

by NHE » Sun Sep 06, 2020 12:39 am » in General Discussion

Transplanted brain cells repair MS damage in mice
May 20th, 2020

When researchers transplanted specific human brain cells into animal models of...

0 Replies

141 Views

Last post by NHE
Sun Sep 06, 2020 12:39 am
Characteristics of multiple sclerosis in patients of Middle Eastern and North African

Last post by Petr75 « Sat Sep 05, 2020 8:40 pm
Posted in MS Etiology and Pathogenesis

by Petr75 » Sat Sep 05, 2020 8:40 pm » in MS Etiology and Pathogenesis

2020 Aug 11
Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada/Division of Neurology,...

0 Replies

117 Views

Last post by Petr75
Sat Sep 05, 2020 8:40 pm
Electroconvulsive therapy

Last post by Petr75 « Sat Sep 05, 2020 11:36 am
Posted in General Discussion

by Petr75 » Sat Sep 05, 2020 11:36 am » in General Discussion

2020 Sep 3
Smadar Goldfarb, Nina Fainstein, Tamir Ben-Hur
Electroconvulsive stimulation attenuates chronic neuroinflammation

Abstract...

0 Replies

136 Views

Last post by Petr75
Sat Sep 05, 2020 11:36 am
Three different biopsy patterns

Last post by frodo « Thu Sep 03, 2020 12:31 am
Posted in MS Etiology and Pathogenesis

by frodo » Thu Sep 03, 2020 12:31 am » in MS Etiology and Pathogenesis

Different pathological processes for acute white matter lesions in multiple sclerosis

Abstract

Introduction :

Multiple sclerosis (MS) has...

0 Replies

97 Views

Last post by frodo
Thu Sep 03, 2020 12:31 am
smoking x MS: quit ASAP

Last post by jimmylegs « Wed Sep 02, 2020 8:40 am
Posted in Mental & Spiritual Health

by jimmylegs » Wed Sep 02, 2020 8:40 am » in Mental & Spiritual Health

The impact of modifiable risk factors on lesion burden in patients with early multiple sclerosis (2020)

...Our results show that smoking status,...

0 Replies

86 Views

Last post by jimmylegs
Wed Sep 02, 2020 8:40 am
infections/vaccines/autoimmunity/MS

Last post by jimmylegs « Wed Sep 02, 2020 8:15 am
Posted in General Discussion

by jimmylegs » Wed Sep 02, 2020 8:15 am » in General Discussion

didn't seem like an intuitive result given the search terms, but okay:

Infections, Vaccines and Autoimmunity: A Multiple Sclerosis Perspective (2020)

0 Replies

139 Views

Last post by jimmylegs
Wed Sep 02, 2020 8:15 am
A pathogenic B cell transcriptome in active multiple sclerosis

Last post by frodo « Tue Sep 01, 2020 5:25 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Sep 01, 2020 5:25 am » in MS Etiology and Pathogenesis

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis

Abstract

Central nervous system B cells have several...

0 Replies

91 Views

Last post by frodo
Tue Sep 01, 2020 5:25 am
EMG

Last post by Petr75 « Mon Aug 31, 2020 11:04 am
Posted in General Discussion

by Petr75 » Mon Aug 31, 2020 11:04 am » in General Discussion

2020 Jul 15
Department of Health Sciences and Research, College of Health Professions, Medical University of South Carolina, Charleston
Can Operant...

0 Replies

144 Views

Last post by Petr75
Mon Aug 31, 2020 11:04 am
Voting

Last post by 1eye « Mon Aug 31, 2020 6:58 am
Posted in General Discussion

by 1eye » Mon Aug 31, 2020 6:58 am » in General Discussion

8)

Chris

0 Replies

121 Views

Last post by 1eye
Mon Aug 31, 2020 6:58 am
Reelin depletion for MS

Last post by jimmylegs « Sun Aug 30, 2020 10:48 am
Posted in MS Etiology and Pathogenesis

by jimmylegs » Sun Aug 30, 2020 10:48 am » in MS Etiology and Pathogenesis

Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes

...Our findings suggest Reelin...

0 Replies

94 Views

Last post by jimmylegs
Sun Aug 30, 2020 10:48 am
Mass cytometry provides insight into the role of B cells

Last post by frodo « Thu Aug 27, 2020 5:43 am
Posted in MS Etiology and Pathogenesis

by frodo » Thu Aug 27, 2020 5:43 am » in MS Etiology and Pathogenesis

Mass cytometry provides unprecedented insight into the role of B cells during the pathogenesis of multiple sclerosis

Abstract

In recent...

0 Replies

95 Views

Last post by frodo
Thu Aug 27, 2020 5:43 am
Lipoic acid modulates inflammatory response in RRMS

Last post by NHE « Thu Aug 27, 2020 2:04 am
Posted in Natural Approach

by NHE » Thu Aug 27, 2020 2:04 am » in Natural Approach

Lipoic acid modulates inflammatory responses of monocytes and monocyte-derived macrophages from healthy and relapsing-remitting multiple sclerosis...

0 Replies

66 Views

Last post by NHE
Thu Aug 27, 2020 2:04 am
NFL shows silent relapses in PPMS cases

Last post by frodo « Tue Aug 25, 2020 8:51 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Aug 25, 2020 8:51 am » in MS Etiology and Pathogenesis

PPMS is supposed to advance in absence of relapses. Anyway, it seems than some silent relapses can be seen via NFL

CSF neurofilament light chain...

0 Replies

98 Views

Last post by frodo
Tue Aug 25, 2020 8:51 am
Response to b-cell depletion can be predicted

Last post by frodo « Sun Aug 23, 2020 11:38 pm
Posted in MS Etiology and Pathogenesis

by frodo » Sun Aug 23, 2020 11:38 pm » in MS Etiology and Pathogenesis

Autoantibodies against central nervous system antigens in a subset of B cell–dominant multiple sclerosis patients

Significance

Multiple...

0 Replies

82 Views

Last post by frodo
Sun Aug 23, 2020 11:38 pm
Sirt6

Last post by Petr75 « Sun Aug 23, 2020 2:40 am
Posted in General Discussion

by Petr75 » Sun Aug 23, 2020 2:40 am » in General Discussion

2020 Jul 31
Ospedale Policlinico San Martino, IRCCS, Largo R, Genova, Italy
Sirt6 inhibition delays the onset of experimental autoimmune...

0 Replies

108 Views

Last post by Petr75
Sun Aug 23, 2020 2:40 am
Thyroid hormone

Last post by Petr75 « Sat Aug 22, 2020 11:50 am
Posted in General Discussion

by Petr75 » Sat Aug 22, 2020 11:50 am » in General Discussion

2020 Jul 9
Department of Pathology, University of Pisa, Italy
Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the...

0 Replies

124 Views

Last post by Petr75
Sat Aug 22, 2020 11:50 am
Ofatumumab vs. Teriflunomide in Multiple Sclerosis, Phase III Trials

Last post by NHE « Sat Aug 22, 2020 4:18 am
Posted in Kesimpta (Ofatumumab)

by NHE » Sat Aug 22, 2020 4:18 am » in Kesimpta (Ofatumumab)

Ofatumumab versus Teriflunomide in Multiple Sclerosis
N Engl J Med. 2020 Aug 6;383(6):546-557.

Background: Ofatumumab, a subcutaneous anti-CD20...

0 Replies

83 Views

Last post by NHE
Sat Aug 22, 2020 4:18 am
Ofatumumab Phase IIb Trial, MIRROR Study

Last post by NHE « Sat Aug 22, 2020 4:05 am
Posted in Kesimpta (Ofatumumab)

by NHE » Sat Aug 22, 2020 4:05 am » in Kesimpta (Ofatumumab)

Subcutaneous ofatumumab in patients with relapsing-remitting multiple sclerosis: The MIRROR study
Neurology. 2018 May 15;90(20):e1805-e1814....

0 Replies

51 Views

Last post by NHE
Sat Aug 22, 2020 4:05 am
Smoking

Last post by Petr75 « Sat Aug 22, 2020 2:47 am
Posted in General Discussion

by Petr75 » Sat Aug 22, 2020 2:47 am » in General Discussion

2020 Jul 30
Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
Methylome and...

0 Replies

115 Views

Last post by Petr75
Sat Aug 22, 2020 2:47 am
New treatment forum: Kesimpta

Last post by NHE « Fri Aug 21, 2020 7:36 pm
Posted in General Discussion

by NHE » Fri Aug 21, 2020 7:36 pm » in General Discussion

Kesimpta, from Novartis, is a subcutaneously injected anti CD20 monoclonal antibody with a similar mode of activity to Ocrevus.

0 Replies

292 Views

Last post by NHE
Fri Aug 21, 2020 7:36 pm
Kesimpta prescribing information

Last post by NHE « Fri Aug 21, 2020 5:43 pm
Posted in Kesimpta (Ofatumumab)

by NHE » Fri Aug 21, 2020 5:43 pm » in Kesimpta (Ofatumumab)

Kesimpta prescribing information.

0 Replies

45 Views

Last post by NHE
Fri Aug 21, 2020 5:43 pm
Skin

Last post by Petr75 « Fri Aug 21, 2020 10:59 am
Posted in General Discussion

by Petr75 » Fri Aug 21, 2020 10:59 am » in General Discussion

2020 Jul 26
Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain
Skin Phototype Could Be a Risk Factor for Multiple Sclerosis...

0 Replies

77 Views

Last post by Petr75
Fri Aug 21, 2020 10:59 am
PET differentiates pathological variants of MS

Last post by frodo « Thu Aug 20, 2020 11:46 pm
Posted in MS Etiology and Pathogenesis

by frodo » Thu Aug 20, 2020 11:46 pm » in MS Etiology and Pathogenesis

TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis

Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and...

0 Replies

56 Views

Last post by frodo
Thu Aug 20, 2020 11:46 pm
The perivascular space (PVS): New frontier in MS research

Last post by frodo « Thu Aug 20, 2020 3:51 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Thu Aug 20, 2020 3:51 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

It seems that the perivascular space is where all begins. This would explain the relationship between MS and vascular problems.

Tissue-resident...

0 Replies

93 Views

Last post by frodo
Thu Aug 20, 2020 3:51 am
Letter to the editor: How do you explain these findings?

Last post by frodo « Thu Aug 20, 2020 3:03 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Thu Aug 20, 2020 3:03 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Letter to the Editor (Phlebological Review 2019; 27, 1: 15-16)

Anatomy of venous abnormalities in multiple sclerosis patients

Dear Editor,...

0 Replies

68 Views

Last post by frodo
Thu Aug 20, 2020 3:03 am
OCB+ and OCB- patients show different evolution

Last post by frodo « Thu Aug 20, 2020 12:25 am
Posted in MS Etiology and Pathogenesis

by frodo » Thu Aug 20, 2020 12:25 am » in MS Etiology and Pathogenesis

It seems that OCB-negative patients show less cerebelar lesions than OCB-positives.

Advanced MRI features in relapsing multiple sclerosis patients...

0 Replies

53 Views

Last post by frodo
Thu Aug 20, 2020 12:25 am
Biomarker for response to interferon: ADC values

Last post by frodo « Thu Aug 20, 2020 12:03 am
Posted in MS Etiology and Pathogenesis

by frodo » Thu Aug 20, 2020 12:03 am » in MS Etiology and Pathogenesis

The role of ADC values within the normal-appearing brain in the prognosis of multiple sclerosis activity during interferon-β therapy in the 3-year...

0 Replies

51 Views

Last post by frodo
Thu Aug 20, 2020 12:03 am
Specific image biomarker: Paramagnetic rim lesions

Last post by frodo « Wed Aug 19, 2020 11:48 pm
Posted in MS Etiology and Pathogenesis

by frodo » Wed Aug 19, 2020 11:48 pm » in MS Etiology and Pathogenesis

Currently there is no specific single test to diagnose MS. This won't be the first one because of its low sensitivity, but they say that specificity...

0 Replies

43 Views

Last post by frodo
Wed Aug 19, 2020 11:48 pm
anti-CD20 works on B-cells but also on T-cells

Last post by frodo « Wed Aug 19, 2020 4:56 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Aug 19, 2020 4:56 am » in MS Etiology and Pathogenesis

Most reports state that anti-CD20 treatment suppresses inflammation, but it also has an effect on the cd8+ T-cell attack.

Unraveling the T–B tangle...

0 Replies

68 Views

Last post by frodo
Wed Aug 19, 2020 4:56 am
MS and Ischemic Stroke

Last post by Petr75 « Mon Aug 17, 2020 11:52 am
Posted in General Discussion

by Petr75 » Mon Aug 17, 2020 11:52 am » in General Discussion

2020 Jul 3
Department of Neurology, Tianjin First Central Hospital, Tianjin, China
Genetic Etiology Shared by Multiple Sclerosis and Ischemic Stroke...

0 Replies

220 Views

Last post by Petr75
Mon Aug 17, 2020 11:52 am
FREE MS Diet Resource!

Last post by TheMSCookbook « Mon Aug 17, 2020 7:53 am
Posted in Diet

by TheMSCookbook » Mon Aug 17, 2020 7:53 am » in Diet

In 2004, my husband was diagnosed with multiple sclerosis, which motivated me to find ways to increase his energy and improve his quality of life....

0 Replies

224 Views

Last post by TheMSCookbook
Mon Aug 17, 2020 7:53 am

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