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Last post

B cells as disease-drivers and therapeutic targets

Last post by jimmylegs « Sun Dec 05, 2021 7:14 am
Posted in MS Etiology and Pathogenesis

by jimmylegs » Sun Dec 05, 2021 7:14 am » in MS Etiology and Pathogenesis

getting up to speed on a few topics :) i've been interested in b10 cells lately.

Update on the autoimmune pathology of multiple sclerosis: B cells...

0 Replies

24 Views

Last post by jimmylegs
Sun Dec 05, 2021 7:14 am
Baclofen cautions

Last post by NHE « Sat Dec 04, 2021 6:20 pm
Posted in General Medications

by NHE » Sat Dec 04, 2021 6:20 pm » in General Medications

The Mayo Clinic reports that withdrawal from baclofen must be done in a tapered protocol in order to avoid severe side effects as discussed below....

0 Replies

25 Views

Last post by NHE
Sat Dec 04, 2021 6:20 pm
Vitamin D3 acts as an antioxidant

Last post by NHE « Wed Dec 01, 2021 12:36 pm
Posted in Natural Approach

by NHE » Wed Dec 01, 2021 12:36 pm » in Natural Approach

Antioxidative effect of vitamin D3 on zinc-induced oxidative stress in CNS
Ann N Y Acad Sci. 2005 Aug;1053:319-29.

Antioxidative mechanisms of...

0 Replies

49 Views

Last post by NHE
Wed Dec 01, 2021 12:36 pm
Towards Comprehensive MS Theory

Last post by jimmylegs « Sun Nov 28, 2021 5:39 am
Posted in General Discussion

by jimmylegs » Sun Nov 28, 2021 5:39 am » in General Discussion

Towards a comprehensive etiopathogenetic and pathophysiological theory of multiple sclerosis

... Conclusions: For better MS prevention and...

0 Replies

90 Views

Last post by jimmylegs
Sun Nov 28, 2021 5:39 am
Nutrition, Exercise, MS

Last post by jimmylegs « Sun Nov 28, 2021 1:56 am
Posted in General Discussion

by jimmylegs » Sun Nov 28, 2021 1:56 am » in General Discussion

The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

... Among the...

0 Replies

73 Views

Last post by jimmylegs
Sun Nov 28, 2021 1:56 am
more about HERVs and HERV-W

Last post by frodo « Fri Nov 26, 2021 2:44 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Nov 26, 2021 2:44 am » in MS Etiology and Pathogenesis

This is a review. There is nothing new, but it is interesting to read:

Human Endogenous Retrovirus and Multiple Sclerosis: a review and...

0 Replies

83 Views

Last post by frodo
Fri Nov 26, 2021 2:44 am
Melatonin inhibits neuroinflammation

Last post by NHE « Thu Nov 25, 2021 8:49 am
Posted in Natural Approach

by NHE » Thu Nov 25, 2021 8:49 am » in Natural Approach

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
Tahir Ali et al. J...

0 Replies

77 Views

Last post by NHE
Thu Nov 25, 2021 8:49 am
PI3K/Akt

Last post by Petr75 « Thu Nov 25, 2021 4:58 am
Posted in General Discussion

by Petr75 » Thu Nov 25, 2021 4:58 am » in General Discussion

2021 Nov 20
Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's...

0 Replies

83 Views

Last post by Petr75
Thu Nov 25, 2021 4:58 am
p21-activated kinases (PAKs)

Last post by Petr75 « Thu Nov 25, 2021 4:40 am
Posted in General Discussion

by Petr75 » Thu Nov 25, 2021 4:40 am » in General Discussion

2021 Nov 22
Department of Neurology, Shriners Hospitals for Children/School of Medicine, Institute for Pediatric Regenerative Medicine (IPRM),...

0 Replies

69 Views

Last post by Petr75
Thu Nov 25, 2021 4:40 am
Epstein-Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci

Last post by Tif « Mon Nov 22, 2021 9:00 am
Posted in MS Etiology and Pathogenesis

by Tif » Mon Nov 22, 2021 9:00 am » in MS Etiology and Pathogenesis

The interplay between environmental and genetic factors plays a key role in the development of many autoimmune diseases. In particular, the...

0 Replies

81 Views

Last post by Tif
Mon Nov 22, 2021 9:00 am
BCI-FES

Last post by Petr75 « Tue Nov 16, 2021 12:10 pm
Posted in General Discussion

by Petr75 » Tue Nov 16, 2021 12:10 pm » in General Discussion

2021 Nov 15
Universidad Nacional de Entre Ríos Facultad de Ingeniería, ARGENTINA
Effects of brain-computer interface with functional electrical...

0 Replies

112 Views

Last post by Petr75
Tue Nov 16, 2021 12:10 pm
Monovaccine (Epstein - Barr virus) Market Overview 2021

Last post by Tif « Tue Nov 16, 2021 10:26 am
Posted in MS Etiology and Pathogenesis

by Tif » Tue Nov 16, 2021 10:26 am » in MS Etiology and Pathogenesis

Hi,

SEATTLE, WASHINGTON, UNITED STATES, November 16, 2021 /EINPresswire.com/ -- The increasing research and development activities and funding...

0 Replies

95 Views

Last post by Tif
Tue Nov 16, 2021 10:26 am
MedDay High-dose Biotin Fails Clinical Trial

Last post by NHE « Sun Nov 14, 2021 8:52 am
Posted in Biotin (Qizenday, Cerenday, MD1003)

by NHE » Sun Nov 14, 2021 8:52 am » in Biotin (Qizenday, Cerenday, MD1003)

Negative Results of High Dose Biotin (MD1003) Clinical Trial Published

October 29, 2020

A large Phase 3 clinical trial of high-dose Biotin...

0 Replies

94 Views

Last post by NHE
Sun Nov 14, 2021 8:52 am
Qunol Sleep?

Last post by NHE « Sat Nov 13, 2021 1:33 pm
Posted in Natural Approach

by NHE » Sat Nov 13, 2021 1:33 pm » in Natural Approach

I’m having difficulty getting regular sleep. I’ve used melatonin and have also combined it with gaba. Sometimes the combo helps, more often it...

0 Replies

86 Views

Last post by NHE
Sat Nov 13, 2021 1:33 pm
CBD Attenuates Neuroinflammation

Last post by NHE « Thu Nov 11, 2021 3:38 pm
Posted in Medical Marijuana

by NHE » Thu Nov 11, 2021 3:38 pm » in Medical Marijuana

Effects of Orally Administered Cannabidiol on Neuroinflammation and Intestinal Inflammation in the Attenuation of Experimental Autoimmune...

0 Replies

101 Views

Last post by NHE
Thu Nov 11, 2021 3:38 pm
Emotion

Last post by Petr75 « Wed Nov 10, 2021 10:46 pm
Posted in General Discussion

by Petr75 » Wed Nov 10, 2021 10:46 pm » in General Discussion

2021 Nov 8
University of Strasbourg and French National Centre for Scientific Research (CNRS), ICube Laboratory UMR 7357 and FMTS (Fédération de...

0 Replies

101 Views

Last post by Petr75
Wed Nov 10, 2021 10:46 pm
Smartphone

Last post by Petr75 « Mon Nov 01, 2021 9:11 am
Posted in General Discussion

by Petr75 » Mon Nov 01, 2021 9:11 am » in General Discussion

2021 Oct 31
Smartphone-derived keystroke dynamics are sensitive to relevant changes in multiple sclerosis

Abstract

Background: To investigate...

0 Replies

234 Views

Last post by Petr75
Mon Nov 01, 2021 9:11 am
A Study to Evaluate Tabelecleucel in Participants With Epstein-barr Virus-associated Diseases

Last post by Tif « Sun Oct 31, 2021 10:12 am
Posted in MS Etiology and Pathogenesis

by Tif » Sun Oct 31, 2021 10:12 am » in MS Etiology and Pathogenesis

ClinicalTrials.gov Identifier: NCT04554914

0 Replies

271 Views

Last post by Tif
Sun Oct 31, 2021 10:12 am
Safety and Immunogenicity of an Epstein-Barr Virus (EBV) gp350-Ferritin Nanoparticle Vaccine in Healthy Adults With or W

Last post by Tif « Sat Oct 30, 2021 12:45 pm
Posted in MS Etiology and Pathogenesis

by Tif » Sat Oct 30, 2021 12:45 pm » in MS Etiology and Pathogenesis

.... on October 27,2021 NIH began enrolling volunteers in a four-year clinical trial to test the safety of and immune response to a vaccine against...

0 Replies

247 Views

Last post by Tif
Sat Oct 30, 2021 12:45 pm
microstructural and metabolic alterations

Last post by frodo « Wed Oct 13, 2021 4:38 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Oct 13, 2021 4:38 am » in MS Etiology and Pathogenesis

Brain microstructural and metabolic alterations detected in vivo at onset of the first demyelinating event

Abstract

In early multiple...

0 Replies

234 Views

Last post by frodo
Wed Oct 13, 2021 4:38 am
soluble factors released from meningeal inflammation as the culprit

Last post by frodo « Wed Oct 13, 2021 4:34 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Oct 13, 2021 4:34 am » in MS Etiology and Pathogenesis

Surface-in pathology in multiple sclerosis: a new view on pathogenesis?

Abstract

While multiple sclerosis can affect any part of the CNS, it...

0 Replies

214 Views

Last post by frodo
Wed Oct 13, 2021 4:34 am
Ofatumumab has the best efficacy

Last post by frodo « Tue Oct 12, 2021 11:53 pm
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 12, 2021 11:53 pm » in MS Etiology and Pathogenesis

Emerging data on the treatment of multiple sclerosis

Background and objectives. In the past few years, a myriad of new studies were aimed to find...

0 Replies

228 Views

Last post by frodo
Tue Oct 12, 2021 11:53 pm
anti-CD20 MABs work by depleting EBV load

Last post by frodo « Tue Oct 12, 2021 11:46 pm
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 12, 2021 11:46 pm » in MS Etiology and Pathogenesis

The cellular immune response against Epstein-Barr virus decreases during ocrelizumab treatment.
Mult Scler Relat Disord. 2021 Sep 28;56:103282. doi:...

0 Replies

252 Views

Last post by frodo
Tue Oct 12, 2021 11:46 pm
Two statistical clusters of lesions

Last post by frodo « Tue Oct 05, 2021 4:32 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 05, 2021 4:32 am » in MS Etiology and Pathogenesis

Lesion features on magnetic resonance imaging discriminate multiple sclerosis patients

Abstract

Background : Magnetic resonance imaging...

0 Replies

261 Views

Last post by frodo
Tue Oct 05, 2021 4:32 am
Prodrome: White matter abnormalities before lesions

Last post by frodo « Tue Oct 05, 2021 4:22 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 05, 2021 4:22 am » in MS Etiology and Pathogenesis

Machine learning to investigate superficial white matter integrity in early multiple sclerosis

Abstract

Background and Purpose

This study...

0 Replies

251 Views

Last post by frodo
Tue Oct 05, 2021 4:22 am
Nervgen remyelination drug phase 1

Last post by DIM « Sun Oct 03, 2021 9:08 am
Posted in Drug Pipeline

by DIM » Sun Oct 03, 2021 9:08 am » in Drug Pipeline

0 Replies

392 Views

Last post by DIM
Sun Oct 03, 2021 9:08 am
older ppl, attitudes, status

Last post by jimmylegs « Sat Sep 25, 2021 9:13 am
Posted in Diet

by jimmylegs » Sat Sep 25, 2021 9:13 am » in Diet

Older Adults Who Use Vitamin/Mineral Supplements Differ from Nonusers in Nutrient Intake Adequacy and Dietary Attitudes

Conclusions

A large...

0 Replies

304 Views

Last post by jimmylegs
Sat Sep 25, 2021 9:13 am
Microglia clean up toxic lipids in multiple sclerosis

Last post by frodo « Fri Sep 24, 2021 12:45 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Sep 24, 2021 12:45 am » in MS Etiology and Pathogenesis

Microglia clean up toxic lipids in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and...

0 Replies

291 Views

Last post by frodo
Fri Sep 24, 2021 12:45 am
Genome Wide Associated Study: Genes involved in lesion locations

Last post by frodo « Thu Sep 23, 2021 11:39 pm
Posted in MS Etiology and Pathogenesis

by frodo » Thu Sep 23, 2021 11:39 pm » in MS Etiology and Pathogenesis

The authors propose that some existing drugs could be repurposed to target each the genetic pathway.

An integrative study of genetic variants with...

0 Replies

257 Views

Last post by frodo
Thu Sep 23, 2021 11:39 pm
getting DRIs right

Last post by jimmylegs « Thu Sep 23, 2021 11:18 am
Posted in Diet

by jimmylegs » Thu Sep 23, 2021 11:18 am » in Diet

aha, 'my people'! ;)

Options for basing Dietary Reference Intakes (DRIs) on chronic disease endpoints: report from a joint US-/Canadian-sponsored...

0 Replies

235 Views

Last post by jimmylegs
Thu Sep 23, 2021 11:18 am
Lenabasum

Last post by Petr75 « Tue Sep 21, 2021 5:20 am
Posted in Medical Marijuana

by Petr75 » Tue Sep 21, 2021 5:20 am » in Medical Marijuana

2021 Sep 20
Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome, Italy
Potent T cell mediated anti-inflammatory role...

0 Replies

221 Views

Last post by Petr75
Tue Sep 21, 2021 5:20 am
Does the venous pressure theory of multiple sclerosis pathophysiology deserve a second chance?

Last post by frodo « Fri Sep 17, 2021 3:01 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Fri Sep 17, 2021 3:01 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Does the venous pressure theory of multiple sclerosis pathophysiology deserve a second chance?

Summary

The theory that multiple sclerosis is...

0 Replies

382 Views

Last post by frodo
Fri Sep 17, 2021 3:01 am
central vein sign and iron in lesion as biomarkers

Last post by frodo « Wed Sep 15, 2021 11:02 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Wed Sep 15, 2021 11:02 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review and meta-analysis

Introduction

Susceptibility-based...

0 Replies

300 Views

Last post by frodo
Wed Sep 15, 2021 11:02 am
Metabolic alterations in MS

Last post by frodo « Wed Sep 15, 2021 10:53 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Sep 15, 2021 10:53 am » in MS Etiology and Pathogenesis

Carbohydrate and lipid metabolism in multiple sclerosis: Clinical implications for etiology, pathogenesis, diagnosis, prognosis, and therapy...

0 Replies

256 Views

Last post by frodo
Wed Sep 15, 2021 10:53 am
well that's just crazy

Last post by jimmylegs « Sat Sep 11, 2021 3:30 pm
Posted in General Discussion

by jimmylegs » Sat Sep 11, 2021 3:30 pm » in General Discussion

things to consider bringing to your family's attention

Reversible coma with prolonged absence of pupillary and brainstem reflexes
An unusual...

0 Replies

289 Views

Last post by jimmylegs
Sat Sep 11, 2021 3:30 pm
JUGULAR VENOUS OUTFLOW DISTURBANCE

Last post by vesta « Sat Sep 11, 2021 10:27 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by vesta » Sat Sep 11, 2021 10:27 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

JUGULAR VENOUS OUTFLOW DISTURBANCE (CEREBRAL VENOUS CONGESTION)

Sound familiar ?
As of 2018 we have a new « condition » which apparently is at the...

0 Replies

337 Views

Last post by vesta
Sat Sep 11, 2021 10:27 am
New-rology :D

Last post by jimmylegs « Fri Sep 10, 2021 3:39 am
Posted in General Discussion

by jimmylegs » Fri Sep 10, 2021 3:39 am » in General Discussion

The development of a diversity, equity, and inclusion committee in a neurology department and residency program (2021)

0 Replies

262 Views

Last post by jimmylegs
Fri Sep 10, 2021 3:39 am
Telitacicept

Last post by Petr75 « Wed Sep 01, 2021 5:23 am
Posted in Drug Pipeline

by Petr75 » Wed Sep 01, 2021 5:23 am » in Drug Pipeline

2021 Aug 31
Springer Nature, Mairangi Bay, New Zealand
Telitacicept: First Approval

Abstract

Telitacicept (Tai'ai®) is fusion protein...

0 Replies

363 Views

Last post by Petr75
Wed Sep 01, 2021 5:23 am
Review from Lassman. It includes "vascular comorbidities" influence.

Last post by frodo « Mon Aug 23, 2021 8:08 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Mon Aug 23, 2021 8:08 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Hans Lassman is one of the heavy weights in research. He has recently written this.

8) How do vascular comorbidities influence multiple...

0 Replies

308 Views

Last post by frodo
Mon Aug 23, 2021 8:08 am
Iron in immunopattern II

Last post by frodo « Mon Aug 23, 2021 7:47 am
Posted in MS Etiology and Pathogenesis

by frodo » Mon Aug 23, 2021 7:47 am » in MS Etiology and Pathogenesis

Iron Heterogeneity in Early Active Multiple Sclerosis Lesions

Abstract

Objective

Multiple sclerosis (MS) is a heterogeneous inflammatory...

0 Replies

268 Views

Last post by frodo
Mon Aug 23, 2021 7:47 am
Two clusters of patients

Last post by frodo « Sat Aug 21, 2021 8:28 am
Posted in MS Etiology and Pathogenesis

by frodo » Sat Aug 21, 2021 8:28 am » in MS Etiology and Pathogenesis

Lesion features on MRI discriminate multiple sclerosis patients

Background: MRI provides insight into various pathological processes in multiple...

0 Replies

306 Views

Last post by frodo
Sat Aug 21, 2021 8:28 am
Dog

Last post by Petr75 « Tue Aug 10, 2021 4:04 am
Posted in General Discussion

by Petr75 » Tue Aug 10, 2021 4:04 am » in General Discussion

2021 Jul 4
Neurology, University of South Florida Morsani College of Medicine, Tampa, USA
Pet Therapy as a Nonpharmacological Treatment Option for...

0 Replies

308 Views

Last post by Petr75
Tue Aug 10, 2021 4:04 am
MRI Usage Guidelines in MS Patients

Last post by NHE « Thu Aug 05, 2021 9:35 am
Posted in General Discussion

by NHE » Thu Aug 05, 2021 9:35 am » in General Discussion

2021 MAGNIMS-CMSC-NAIMS Consensus Recommendations on the Use of MRI in Patients with Multiple Sclerosis
Lancet Neurol. 2021 Aug;20(8):653-670....

0 Replies

328 Views

Last post by NHE
Thu Aug 05, 2021 9:35 am
ms sux!

Last post by jimmylegs « Tue Aug 03, 2021 11:50 pm
Posted in Humor

by jimmylegs » Tue Aug 03, 2021 11:50 pm » in Humor

0 Replies

541 Views

Last post by jimmylegs
Tue Aug 03, 2021 11:50 pm
IgG M predicts immunosenescense

Last post by frodo « Sun Aug 01, 2021 4:19 am
Posted in MS Etiology and Pathogenesis

by frodo » Sun Aug 01, 2021 4:19 am » in MS Etiology and Pathogenesis

Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis...

0 Replies

265 Views

Last post by frodo
Sun Aug 01, 2021 4:19 am
Equine-assisted therapies

Last post by Petr75 « Sat Jul 31, 2021 7:01 am
Posted in General Discussion

by Petr75 » Sat Jul 31, 2021 7:01 am » in General Discussion

2021 Jul 23
VALFIS Research Group, Institute of Biomedicine (IBIOMED), Faculty of Physical Activity and Sports Sciences, University of León, Spain...

0 Replies

274 Views

Last post by Petr75
Sat Jul 31, 2021 7:01 am
Microglia in the NAWM

Last post by frodo « Sat Jul 31, 2021 6:03 am
Posted in MS Etiology and Pathogenesis

by frodo » Sat Jul 31, 2021 6:03 am » in MS Etiology and Pathogenesis

Longitudinal change in TSPO PET imaging in progressive multiple sclerosis

The objective of this pilot study was to assess a 2-year change in...

0 Replies

287 Views

Last post by frodo
Sat Jul 31, 2021 6:03 am
Metabolic abnormalities in MS

Last post by frodo « Sat Jul 31, 2021 5:08 am
Posted in MS Etiology and Pathogenesis

by frodo » Sat Jul 31, 2021 5:08 am » in MS Etiology and Pathogenesis

In vivo evidence of differential frontal cortex metabolic abnormalities in progressive and relapsing-remitting multiple sclerosis

The...

0 Replies

301 Views

Last post by frodo
Sat Jul 31, 2021 5:08 am
Ribose for MS fatigue

Last post by NHE « Mon Jul 26, 2021 3:31 am
Posted in Natural Approach

by NHE » Mon Jul 26, 2021 3:31 am » in Natural Approach

Supplemental d-ribose helps the body synthesize ATP. Have you tried d-ribose for MS fatigue? Was it helpful?

0 Replies

277 Views

Last post by NHE
Mon Jul 26, 2021 3:31 am
Hi all, well there was one small benefit from my displaced Stent.

Last post by CureIous « Sat Jul 24, 2021 4:09 pm
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by CureIous » Sat Jul 24, 2021 4:09 pm » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Long time
Exactly 1 month ago, I had a C4-7 disc fusion, hybrid surgery. You can clearly see my left side stovepipe , they came in from the right...

0 Replies

324 Views

Last post by CureIous
Sat Jul 24, 2021 4:09 pm

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