Search found 5107 matches

by NHE
Thu May 02, 2019 9:59 am
Forum: General Discussion
Topic: Thyroid analog promotes remyelination in mice
Replies: 0
Views: 93

Thyroid analog promotes remyelination in mice

Myelin repair stimulated by CNS-selective thyroid hormone action JCI Insight. 2019;4(8):e126329. Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (MS), leads to neurodegeneration and disability. There are curr...
by NHE
Wed May 01, 2019 8:05 pm
Forum: Undiagnosed
Topic: Diagnosed with CIS today, more tests to come - things to know/ask?
Replies: 48
Views: 1635

Re: Diagnosed with CIS today, more tests to come - things to know/ask?

Well, the symptoms weren't gone with the oral steroids, so I started 1g IV prednisone today. Is it normal for symptoms to become seriously exacerbated after a high dose of that, for at least the first day? In my experience, MS patients in the midst of an exacerbation typically report feeling better...
by NHE
Tue Apr 30, 2019 12:57 am
Forum: Undiagnosed
Topic: Diagnosed with CIS today, more tests to come - things to know/ask?
Replies: 48
Views: 1635

Re: Diagnosed with CIS today, more tests to come - things to know/ask?

"I doubt I can expect to go a whole 8 years before another episode" Actually for most with MS this is not necessarily unusual. And fortunately there is a lot you can do to improve your chances of this outcome. Indeed! The lipoic acid trial by Oregon Health & Science University found a 68% reduction...
by NHE
Mon Apr 29, 2019 12:37 am
Forum: Undiagnosed
Topic: Diagnosed with CIS today, more tests to come - things to know/ask?
Replies: 48
Views: 1635

Re: Diagnosed with CIS today, more tests to come - things to know/ask?

I was symptom free for 8 years after my first attack and my second attack led to my diagnosis. As far as medication goes, I could have taken anything for those 8 years and, if I had, I likely would have concluded that the medication was really helping me. However, being symptom free for 8 years was ...
by NHE
Sun Apr 28, 2019 7:43 pm
Forum: Mental & Spiritual Health
Topic: 2018 review: Magnesium in addiction
Replies: 2
Views: 178

Re: 2018 review: Magnesium in addiction

Here's a more realistic perspective on the problem.

Frontline: Chasing Heroin

https://www.pbs.org/wgbh/frontline/film/chasing-heroin/
by NHE
Sat Apr 27, 2019 2:53 pm
Forum: Mayzent (Siponimod)
Topic: Siponimod reduces risk of disability progression by 21%
Replies: 2
Views: 736

Re: Siponimod reduces risk of disability progression by 21%

Scientists who conducted a randomised, double-blind, placebo-controlled, phase III study, evaluating siponimod versus a placebo in patients with secondary progressive multiple sclerosis (SPMS) have managed to reduce the risk of disability progression by 21 per cent. That sounds good. However, it's ...
by NHE
Sat Apr 27, 2019 2:23 pm
Forum: Undiagnosed
Topic: Diagnosed with CIS today, more tests to come - things to know/ask?
Replies: 48
Views: 1635

Re: Diagnosed with CIS today, more tests to come - things to know/ask?

If I had clinically isolated syndrome with magnetic imaging diagnostic of multiple sclerosis, I would take vitamin D 10,000 IU daily: Yes Multiple Sclerosis Journal, 2013 Jorge Correale http://msj.sagepub.com/content/19/2/137.full.pdf Only with sufficient magnesium supplementation, e.g., 400-600 mg...
by NHE
Sat Apr 27, 2019 3:46 am
Forum: Undiagnosed
Topic: Diagnosed with CIS today, more tests to come - things to know/ask?
Replies: 48
Views: 1635

Re: Diagnosed with CIS today, more tests to come - things to know/ask?

Hi AmbiCat.
Welcome to ThisIsMS. A deficiency in vitamin B12 can cause demyelination of the spinal cord. Have you had your vitamin B12 level tested? If so, what was the value (usually in pg/mL)?
by NHE
Thu Apr 25, 2019 3:08 pm
Forum: General Discussion
Topic: New treatment forum - Mavenclad
Replies: 0
Views: 426

New treatment forum - Mavenclad

Mavenclad (cladribine) is an oral treatment for relapsing MS and active secondary progressive MS. MAVENCLAD is a purine antimetabolite indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include relapsing-remitting disease and active secondary progressive disease, in adults...
by NHE
Thu Apr 25, 2019 12:30 pm
Forum: Mayzent (Siponimod)
Topic: Mayzent prescribing information
Replies: 0
Views: 111

Mayzent prescribing information

by NHE
Thu Apr 25, 2019 12:28 pm
Forum: General Discussion
Topic: New treatment forum - Mayzent
Replies: 0
Views: 369

New treatment forum - Mayzent

Mayzent is an oral treatment for relapse remitting MS and active secondary progressive MS. MAYZENT is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and acti...
by NHE
Fri Apr 19, 2019 10:53 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Notes from CureIous' at Stanford
Replies: 352
Views: 66115

Re: Notes from CureIous' at Stanford

Hi CureIous, You just hope and pray it doesnt disintegrate or cause problems in the lung it feeds, oh wait forget about it that has already happened. I'm sad to hear that your dislodged stent is causing problems. I remember that you did so well initially. How is the stent affecting your lung? I ofte...
by NHE
Fri Apr 19, 2019 1:20 am
Forum: General Discussion
Topic: Focus on the gut-brain axis
Replies: 32
Views: 2615

Re: Focus on the gut-brain axis

Petr75 wrote:
Thu Apr 18, 2019 8:21 pm
2018 Jan
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester
Microbiome, Immunomodulation, and the Neuronal System.
Free full text. https://www.ncbi.nlm.nih.gov/pmc/articl ... le_601.pdf
by NHE
Tue Apr 16, 2019 10:57 am
Forum: Undiagnosed
Topic: B12 question
Replies: 32
Views: 806

Re: B12 question

This limbo place is uncomfortable, to put it mildly. In the meantime, I am interested in taking the best care I can of myself whatever the case. I didn't have a chance to look at it again before my appointment today but I did take the blood test list that you suggested and I'm scheduled to go back ...