Search found 1521 matches

by frodo
Thu Aug 27, 2020 5:43 am
Forum: MS Etiology and Pathogenesis
Topic: Mass cytometry provides insight into the role of B cells
Replies: 0
Views: 167

Mass cytometry provides insight into the role of B cells

Mass cytometry provides unprecedented insight into the role of B cells during the pathogenesis of multiple sclerosis https://www.acnr.co.uk/wp-content/uploads/2020/08/ACNR-2020-V19I3PP12to14.pdf Abstract In recent years, it has become clear that B cells play a prominent role in the pathogenesis of ...
by frodo
Tue Aug 25, 2020 8:51 am
Forum: MS Etiology and Pathogenesis
Topic: NFL shows silent relapses in PPMS cases
Replies: 0
Views: 177

NFL shows silent relapses in PPMS cases

PPMS is supposed to advance in absence of relapses. Anyway, it seems than some silent relapses can be seen via NFL CSF neurofilament light chain testing as an aid to determine treatment strategies in MS https://nn.neurology.org/content/7/6/e880 Abstract Objective To evaluate the use of CSF neurofila...
by frodo
Sun Aug 23, 2020 11:38 pm
Forum: MS Etiology and Pathogenesis
Topic: Response to b-cell depletion can be predicted
Replies: 0
Views: 162

Response to b-cell depletion can be predicted

Autoantibodies against central nervous system antigens in a subset of B cell–dominant multiple sclerosis patients https://www.pnas.org/content/early/2020/08/17/2011249117.short Significance Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). B cells play a key role...
by frodo
Thu Aug 20, 2020 11:46 pm
Forum: MS Etiology and Pathogenesis
Topic: PET differentiates pathological variants of MS
Replies: 0
Views: 95

PET differentiates pathological variants of MS

TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló’s Concentric Sclerosis https://journals.lww.com/nuclearmed/Abstract/9000/TSPO_PET_With_18F_GE_180_to_Differentiate_Variants.96521.aspx Abstract PET ta...
by frodo
Thu Aug 20, 2020 3:51 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: The perivascular space (PVS): New frontier in MS research
Replies: 0
Views: 129

The perivascular space (PVS): New frontier in MS research

It seems that the perivascular space is where all begins. This would explain the relationship between MS and vascular problems. Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions https://academic.oup.com/brain/article/143/6/1714/5836675 Abstract Mul...
by frodo
Thu Aug 20, 2020 3:03 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Letter to the editor: How do you explain these findings?
Replies: 0
Views: 120

Letter to the editor: How do you explain these findings?

Letter to the Editor (Phlebological Review 2019; 27, 1: 15-16) Anatomy of venous abnormalities in multiple sclerosis patients https://www.termedia.pl/Anatomy-of-venous-abnormalities-in-multiple-sclerosis-patients,76,40026,1,1.html Dear Editor, More than ten years have passed since the publication of...
by frodo
Thu Aug 20, 2020 2:52 am
Forum: MS Etiology and Pathogenesis
Topic: Retinal damage could be due to subclinical inflammation in optic nerve
Replies: 1
Views: 183

More about retinal damage: microstructural vascular changes

Characterization of Retinal vascular changes in Multiple Sclerosis using Adaptive Optics and OCTA https://iovs.arvojournals.org/article.aspx?articleid=2768856 Abstract Purpose : Characterize microstructural retinal vascular changes in humans MS using AO-SLO. Methods : This prospective, observationa...
by frodo
Thu Aug 20, 2020 12:25 am
Forum: MS Etiology and Pathogenesis
Topic: OCB+ and OCB- patients show different evolution
Replies: 0
Views: 92

OCB+ and OCB- patients show different evolution

It seems that OCB-negative patients show less cerebelar lesions than OCB-positives. Advanced MRI features in relapsing multiple sclerosis patients with and without CSF oligoclonal IgG bands https://www.nature.com/articles/s41598-020-70693-9 Abstract Oligoclonal IgG bands (OCB) in cerebrospinal fluid...
by frodo
Thu Aug 20, 2020 12:03 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarker for response to interferon: ADC values
Replies: 0
Views: 85

Biomarker for response to interferon: ADC values

The role of ADC values within the normal-appearing brain in the prognosis of multiple sclerosis activity during interferon-β therapy in the 3-year follow-up: a preliminary report https://search.proquest.com/docview/2428762402?pq-origsite=gscholar&fromopenview=true Predictors of multiple sclerosis (...
by frodo
Wed Aug 19, 2020 11:48 pm
Forum: MS Etiology and Pathogenesis
Topic: Specific image biomarker: Paramagnetic rim lesions
Replies: 0
Views: 83

Specific image biomarker: Paramagnetic rim lesions

Currently there is no specific single test to diagnose MS. This won't be the first one because of its low sensitivity, but they say that specificity is 100% when PRL (paramagnetic rim lesions) is used together with OCB's, CVS (central vein sign) and DIS (dissemination in space) CVS detection alone h...
by frodo
Wed Aug 19, 2020 5:07 am
Forum: MS Etiology and Pathogenesis
Topic: Biotin could make MS worse
Replies: 2
Views: 250

Re: Biotin could make MS worse

I didn't know that. Thanks.
by frodo
Wed Aug 19, 2020 4:56 am
Forum: MS Etiology and Pathogenesis
Topic: anti-CD20 works on B-cells but also on T-cells
Replies: 0
Views: 104

anti-CD20 works on B-cells but also on T-cells

Most reports state that anti-CD20 treatment suppresses inflammation, but it also has an effect on the cd8+ T-cell attack. Unraveling the T–B tangle in anti-CD20 multiple sclerosis therapy https://www.pnas.org/content/116/51/25376 Multiple sclerosis (MS) is an inflammatory T cell-mediated disease of ...
by frodo
Mon Aug 17, 2020 2:47 am
Forum: MS Etiology and Pathogenesis
Topic: biochemical signature of progressive multiple sclerosis
Replies: 0
Views: 245

biochemical signature of progressive multiple sclerosis

A biochemical signature of progressive multiple sclerosis https://www.diva-portal.org/smash/record.jsf?pid=diva2%3A1455546&dswid=-472 Abstract Currently, very few treatments for patients in the progressive phases of multiple sclerosis (PMS) are available. To enable sensitive evaluation of future tr...
by frodo
Mon Aug 17, 2020 12:33 am
Forum: MS Etiology and Pathogenesis
Topic: Failed trials that can yield some clues into pathogenesis
Replies: 0
Views: 195

Failed trials that can yield some clues into pathogenesis

This paper speaks about several failures in clinical trials. Among them Atacicept, Tabalumab, Abatacept, Vitamin D, Temelimab (surprinsingly), Raltegravir, Rituximab (in PPMS), Imilecleucel (TCelna, Tovaxin), Fingolimod (for PPMS), Natalizumab for PPMS and Cyclophosphamide for SPMS, Failed, Interrup...
by frodo
Wed Aug 12, 2020 11:14 am
Forum: MS Etiology and Pathogenesis
Topic: biomarkers for pediatric MS
Replies: 0
Views: 199

biomarkers for pediatric MS

Analysis of plasma protein biomarkers in childhood onset multiple sclerosis https://www.sciencedirect.com/science/article/pii/S0165572820303246 Highlights • Significant proteomic differences were found between pediatric MS and healthy control groups. • The detected proteins were mostly in coagulati...

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