Search found 1521 matches

by frodo
Wed Aug 12, 2020 10:58 am
Forum: MS Etiology and Pathogenesis
Topic: biomarker for response to IFNbeta
Replies: 0
Views: 198

biomarker for response to IFNbeta

IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis https://www.sciencedirect.com/science/article/pii/S0024320520309851 Highlights • No biomarker is available for predicting treatment response and neuroinflammation in Multiple Sclerosis. • IFI35 increase...
by frodo
Wed Aug 12, 2020 9:37 am
Forum: General Discussion
Topic: ANAVEX2-73
Replies: 8
Views: 868

Re: ANAVEX2-73

Thanks. Interesting.
by frodo
Wed Aug 12, 2020 12:12 am
Forum: MS Etiology and Pathogenesis
Topic: Metallic elements in MS
Replies: 0
Views: 176

Metallic elements in MS

A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by icp‑MS https://search.proquest.com/docview/2430244991?pq-origsite=gscholar&fromopenview=true It is estimated that multiple sclerosis (MS) affects 35,000 Brazilians and 2.5 m...
by frodo
Tue Aug 11, 2020 2:32 am
Forum: MS Etiology and Pathogenesis
Topic: Retinal damage could be due to subclinical inflammation in optic nerve
Replies: 1
Views: 185

Retinal damage could be due to subclinical inflammation in optic nerve

Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years https://www.nature.com/articles/s41598-020-70255-z The mechanisms by which the retina is damaged in MS may involve primary retinal degeneration, trans-synaptic degeneration due to l...
by frodo
Tue Aug 11, 2020 2:13 am
Forum: MS Etiology and Pathogenesis
Topic: Biotin could make MS worse
Replies: 2
Views: 250

Biotin could make MS worse

Not good news for those on Biotin, but very interesting from the point of view of the pathogenesis research. The Rise and Fall of High-Dose Biotin to Treat Progressive Multiple Sclerosis https://link.springer.com/content/pdf/10.1007/s13311-020-00907-5.pdf Excerpt Thus, whether HDB (high dose biotin)...
by frodo
Tue Aug 11, 2020 2:06 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarker for the progressive phase
Replies: 0
Views: 169

Biomarker for the progressive phase

Distinctive sphingolipid patterns in chronic multiple sclerosis lesions https://www.jlr.org/content/early/2020/08/07/jlr.RA120001022.abstract Abstract Multiple sclerosis (MS) is a CNS disease characterized by immune-mediated demyelination and progressive axonal loss. MS-related CNS damage and its c...
by frodo
Tue Aug 11, 2020 2:03 am
Forum: MS Etiology and Pathogenesis
Topic: Rituxan better than Fingolimod, Dymethyl fumarate and Natalizumab
Replies: 0
Views: 164

Rituxan better than Fingolimod, Dymethyl fumarate and Natalizumab

Rituxan better than Fingolimod, Dymethyl fumarate and Natalizumab https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51111 Interpretation RTX demonstrated superior effectiveness and discontinuation outcomes compared to FTY and DMF. Although RTX demonstrated similar effectiveness and discontinuati...
by frodo
Thu Aug 06, 2020 7:39 am
Forum: MS Etiology and Pathogenesis
Topic: Novel blood-based biomarker for MS
Replies: 0
Views: 173

Novel blood-based biomarker for MS

Blood platelet RNA enables the detection of multiple sclerosis https://journals.sagepub.com/doi/full/10.1177/2055217320946784 Background In multiple sclerosis (MS), clinical assessment, MRI and cerebrospinal fluid are important in the diagnostic process. However, no blood biomarker has been confirm...
by frodo
Thu Jul 30, 2020 11:52 pm
Forum: MS Etiology and Pathogenesis
Topic: Retinal damage is not due to inflammation but MS process itself
Replies: 0
Views: 198

Retinal damage is not due to inflammation but MS process itself

Optical coherence tomography angiography in multiple sclerosis: A cross-sectional study https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236090 Objectives To evaluate retinal axonal density and retinal capillary flow density (CFD) variations in patients affected by multiple scleros...
by frodo
Thu Jul 30, 2020 11:49 pm
Forum: MS Etiology and Pathogenesis
Topic: Clinical course can be predicted
Replies: 0
Views: 154

Clinical course can be predicted

Clinical course can be predicted by a panel of 28 CSF biomarkers Disease phenotype prediction in multiple sclerosis https://www.diva-portal.org/smash/record.jsf?pid=diva2%3A1455173&dswid=-1635 Abstract Early identification of patients at risk for early conversion to progressive multiple sclerosis (P...
by frodo
Tue Jul 21, 2020 2:09 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers: Amino-acid and acylcarnitine profiles
Replies: 0
Views: 208

Biomarkers: Amino-acid and acylcarnitine profiles

Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls https://www.hindawi.com/journals/msi/2020/9010937/ Abstract McDonald criteria and magnetic resonance imaging (MRI) are used for the diagnosis of multiple sclerosis (MS);...
by frodo
Tue Jul 21, 2020 1:54 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarker: N-glucosylation in Multiple Sclerosis
Replies: 0
Views: 171

Biomarker: N-glucosylation in Multiple Sclerosis

A Multiple N-Glucosylated Peptide Epitope Efficiently Detecting Antibodies in Multiple Sclerosis https://www.mdpi.com/2076-3425/10/7/453 Abstract Diagnostics of Multiple Sclerosis (MS) are essentially based on the gold standard magnetic resonance imaging. Few alternative simple assays are available ...
by frodo
Tue Jul 21, 2020 1:33 am
Forum: MS Etiology and Pathogenesis
Topic: HIV prevents MS relapses
Replies: 0
Views: 200

HIV prevents MS relapses

Acquisition of human immunodeficiency virus infection in a patient with multiple sclerosis: could these conditions positively influence each other’s course? https://link.springer.com/article/10.1007/s13365-020-00876-7 Abstract Patients with human immunodeficiency virus (HIV) infection have a decrea...
by frodo
Tue Jul 21, 2020 1:29 am
Forum: MS Etiology and Pathogenesis
Topic: The lancet. Open call for using NFL in diagnosis and monitoring
Replies: 1
Views: 154

International panel on the same subject

Serum neurofilament light as a biomarker in progressive multiple sclerosis https://n.neurology.org/content/early/2020/07/16/WNL.0000000000010346.abstract Abstract There is an unmet need in multiple sclerosis (MS) therapy for treatments to stop progressive disability. The development of treatments ma...

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