Search found 1521 matches

by frodo
Tue Jul 21, 2020 1:26 am
Forum: MS Etiology and Pathogenesis
Topic: Cacciaguerra’s criteria. Difference between MS, NMO and MOG
Replies: 0
Views: 157

Cacciaguerra’s criteria. Difference between MS, NMO and MOG

Evaluation of brain and spinal cord lesion distribution criteria at disease onset in distinguishing NMOSD from MS and MOG antibody-associated disorder https://journals.sagepub.com/doi/abs/10.1177/1352458520939008 Objective: To validate the recently proposed imaging criteria in distinguishing aquapo...
by frodo
Tue Jul 21, 2020 1:18 am
Forum: MS Etiology and Pathogenesis
Topic: cytotoxic B lymphocytes
Replies: 0
Views: 140

cytotoxic B lymphocytes

Study of b lymphocyte subpopulations in the peripheral blood and cephalorraquidian liquid of patients with primary progressive multiple sclerosis http://repositorio.unicamp.br/handle/REPOSIP/345646 Abstract : B lymphocytes actively participate in the pathogenesis of Multiple Sclerosis (MS). The aut...
by frodo
Fri Jul 17, 2020 9:13 am
Forum: MS Etiology and Pathogenesis
Topic: Last review about EBV
Replies: 0
Views: 233

Last review about EBV

State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of Multiple Sclerosis https://link.springer.com/article/10.1007/s40120-020-00202-7 Basic and Applied Molecular Research Molecular research is a key field...
by frodo
Tue Jul 14, 2020 7:41 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarker in the skin. Fibroblasts
Replies: 0
Views: 173

Biomarker in the skin. Fibroblasts

Information about fibroblasts in wikipedia: https://en.wikipedia.org/wiki/Dermal_fibroblast Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis https://pubmed.ncbi.nlm.nih.gov/32640422/ Abstract Multiple sclerosis (MS) is a central nervous sy...
by frodo
Mon Jul 13, 2020 8:50 am
Forum: MS Etiology and Pathogenesis
Topic: The picture of demyelinating diseases gets more complicated
Replies: 1
Views: 687

News about NFs: Plasma exchange for Immune-Mediated Neuropathies

Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies Abstract The inflammatory neuropathies are disabling conditions with diverse immunological mechanisms. In some, a pathogenic role for immunoglobulin G (IgG)-class autoantibodies is increasingly apprec...
by frodo
Mon Jul 13, 2020 8:26 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers: MRZ reaction distinguish MS and other disorders
Replies: 1
Views: 889

MRZ test extended: EMMRZ panel

Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis https://www.sciencedirect.com/science/article/pii/S0165572820302484 Abstract Antibody indices to MRZ are of diagnostic value in multiple sclerosis (MS). Here, we have investigated, if this panel could ...
by frodo
Mon Jul 13, 2020 8:21 am
Forum: MS Etiology and Pathogenesis
Topic: IMPORTANT: Dysfunctional RNA‐binding proteins in MS
Replies: 0
Views: 153

IMPORTANT: Dysfunctional RNA‐binding proteins in MS

As far as I know this is the first time that something like this has been reported. Neuronal RNA‐binding protein dysfunction in multiple sclerosis cortex https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51103 Abstract Objective Neurodegeneration is thought to be the primary cause of neurologica...
by frodo
Mon Jul 13, 2020 8:16 am
Forum: Drug Pipeline
Topic: Remarkable Recovery of Fulminant MS with Cyclophosphamide.
Replies: 0
Views: 261

Remarkable Recovery of Fulminant MS with Cyclophosphamide.

Remarkable Recovery of Fulminant Multiple Sclerosis After Treatment Induction with Cyclophosphamide. http://web.b.ebscohost.com/abstract?site=ehost&scope=site&jrnl=15372073&AN=144209763&h=yZyokUHB%2bE9b1GA9HYEaAdybFyyKTlBsSas8%2bjGTpnkSxj%2bVfqsIytSMS0EPbtTD2%2bHELU01PAInWy%2bz2M4K%2bw%3d%3d&crl=c&...
by frodo
Mon Jul 13, 2020 8:12 am
Forum: MS Etiology and Pathogenesis
Topic: Siponimod reduces progression with or without relapses
Replies: 0
Views: 195

Siponimod reduces progression with or without relapses

Siponimod Affects Disability Progression in Patients with Secondary Progressive Multiple Sclerosis Independent of Relapse Activity http://web.b.ebscohost.com/abstract?site=ehost&scope=site&jrnl=15372073&AN=144209775&h=25PC1G9eT1ua1b0Qqp9tAThM%2f9LRpfSsHbfL0TBUktAxNsoVil7Kc9wT28vexJOWixLCnriMq5RILN4W...
by frodo
Tue Jun 30, 2020 3:02 am
Forum: Tecfidera (BG-12, dimethyl fumarate)
Topic: Two new FDA approvals. Vumerity and Bafiertam. Tecfidera bioequivalents.
Replies: 0
Views: 250

Two new FDA approvals. Vumerity and Bafiertam. Tecfidera bioequivalents.

Two new FDA approvals. Both are bioequivalents to Dymethyl fumarate / Tecfidera. Diroximel fumerate (Vumerity). Approved by the FDA in October of 2019 https://investors.biogen.com/news-releases/news-release-details/biogen-and-alkermes-announce-fda-approval-vumeritytm-diroximel Monomethyl fumarate (B...
by frodo
Tue Jun 30, 2020 2:59 am
Forum: General Discussion
Topic: Two new FDA approvals. Vumerity and Bafiertam
Replies: 1
Views: 204

Two new FDA approvals. Vumerity and Bafiertam

Two new FDA approvals. Both are bioequivalents to Dymethyl fumarate / Tecfidera. Diroximel fumerate (Vumerity). Approved by the FDA in October of 2019 https://investors.biogen.com/news-releases/news-release-details/biogen-and-alkermes-announce-fda-approval-vumeritytm-diroximel Monomethyl fumarate (B...
by frodo
Tue Jun 30, 2020 12:37 am
Forum: MS Etiology and Pathogenesis
Topic: Highly active MS and specific treatment
Replies: 0
Views: 186

Highly active MS and specific treatment

It is not an official but regulatory agencies considered the highly active MS (HAMS) separated from the rest in their approval processes for cladribine/mavenclad (https://www.merckgroup.com/en/news/mavenclad-25-08-2017.html) Now is the same for Russia https://nnp.ima-press.net/nnp/article/view/1359 ...
by frodo
Tue Jun 30, 2020 12:05 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Cortical Grey Matter Hypoxia in MS
Replies: 3
Views: 429

Cortical Grey Matter Hypoxia in MS

Investigating the Relationship Between Cortical Grey Matter Hypoxia and Disability in Multiple Sclerosis https://prism.ucalgary.ca/handle/1880/112222 Abstract Multiple sclerosis (MS) is a progressive neurological disease characterized by inflammation and neurodegeneration. These pathological proces...
by frodo
Mon Jun 29, 2020 12:17 am
Forum: MS Etiology and Pathogenesis
Topic: Microglia are the culprits for slowly expanding lesions
Replies: 0
Views: 118

Microglia are the culprits for slowly expanding lesions

Slowly expanding lesions are suspected to be the cause of the MS progressive phase. Microglia and macrophages are cells that look similar and were previously impossible to separate, but now it is possible with a specific marker (TMEM119). This has shown that microglia and not macrophages are the cul...

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