Search found 411 matches

by Squeakycat
Thu Dec 19, 2013 12:19 pm
Forum: General Discussion
Topic: Jimmylegs...too much vitamin d = ouch?
Replies: 271
Views: 19193

Re: Jimmylegs...too much vitamin d = ouch?

[1]In your post before this, are you trying to say calcitriol is essential to all cell death and/or inflammation? It seems to me like there could still be cell death and inflammation without its involvement...but maybe it is essential for the death of certain cells. [2]If plain old 25OH is parking ...
by Squeakycat
Wed Dec 18, 2013 8:02 pm
Forum: General Discussion
Topic: Jimmylegs...too much vitamin d = ouch?
Replies: 271
Views: 19193

Re: Jimmylegs...too much vitamin d = ouch?

Hard to read the quote in any other way: "However, vitamin D 25-hydroxy levels do not indicate the amount of vitamin D stored in your bodys tissues. [/size] Vitamin D, 1, 25-hydroxy is a better indicator of stored vitamin D . . ." That's funny...I can't read that vitamin d stores paragraph the way ...
by Squeakycat
Wed Dec 18, 2013 7:55 pm
Forum: General Discussion
Topic: Jimmylegs...too much vitamin d = ouch?
Replies: 271
Views: 19193

Re: Jimmylegs...too much vitamin d = ouch?

I wasn't speaking of the Blaney study. I was referring to the ideas of the authors of the page. It follows that any substance that slows the innate immune response will decrease this battle between man and microbe, causing the patient to feel better. The more the immune response is slowed, the grea...
by Squeakycat
Wed Dec 18, 2013 5:41 pm
Forum: General Discussion
Topic: Jimmylegs...too much vitamin d = ouch?
Replies: 271
Views: 19193

Re: Jimmylegs...too much vitamin d = ouch?

I've also dug up a page that claims the high calcitriol to low d ratio seen in ms may be protective. http://bacteriality.com/2009/08/10/iom/. It's not well supported...but neither are the theories pushing higher vitamin d levels (as far as I can tell). I don't think the Blaney study on which the ar...
by Squeakycat
Wed Dec 18, 2013 5:27 pm
Forum: General Discussion
Topic: Jimmylegs...too much vitamin d = ouch?
Replies: 271
Views: 19193

Re: Jimmylegs...too much vitamin d = ouch?

Hi squeaky, Thanks! I was trying that approach but with vitamin d too. I couldn't do 1200iu d, 400mg calcium, 400mg mag and some other nutrients like zinc without causing pain. Did she supplement the calcium combo while completely stopping d supps? 1,25OH is also supposed to shut down pth...I'm tem...
by Squeakycat
Wed Dec 18, 2013 4:14 pm
Forum: General Discussion
Topic: Jimmylegs...too much vitamin d = ouch?
Replies: 271
Views: 19193

Re: Jimmylegs...too much vitamin d = ouch?

Low serum phosphorus levels stimulate calcitriol synthesis, whereas high serum phosphorus levels inhibit it. http://www.ncbi.nlm.nih.gov/books/NBK56061/ So, your high levels of calcitriol would be the result of low phosphorous levels, according to THE book of Vitamin D, Dietary Reference Intakes fo...
by Squeakycat
Wed Dec 18, 2013 3:45 pm
Forum: General Discussion
Topic: Jimmylegs...too much vitamin d = ouch?
Replies: 271
Views: 19193

Re: Jimmylegs...too much vitamin d = ouch?

'Splain this... Concentration of vitamin D 25-hydroxy is the best indicator of your vitamin D status. It reflects vitamin D produced and obtained by your body and has a half-life of 15 days. However, vitamin D 25-hydroxy levels do not indicate the amount of vitamin D stored in your bodys tissues. V...
by Squeakycat
Sun Dec 15, 2013 6:19 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118608

Re: all things vitamin D

Maybe we need to ask some MS organization to make and fund such trial as soon as possible (or I hope they are doing that already) ! There should be some possibilites to accelerate this process not to wait years for the results... Doest need FDA approval :) Even ccsvi was investigated a lot in the p...
by Squeakycat
Sun Dec 15, 2013 4:26 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118608

Re: all things vitamin D

Is there any significant risk in trying the one dose of calcitriol and d3 regimen afterwards? I have been taking d3 for almost a year daily (5.000-10.000 iu in the form of vit. d3 water based drops) having my blood checked for d3 and calcium/creatinin levels every 2-3 months. The d3 levels varied f...
by Squeakycat
Fri Dec 13, 2013 1:08 pm
Forum: General Discussion
Topic: Single Calcitriol Dose Beats Back EAE in Mice
Replies: 17
Views: 2499

Re: Single Calcitriol Dose Beats Back EAE in Mice

Any word on trials? I certainly am up for it. Apparently, I am not deficient in anything by the results of my bloodwork for tecfidera and more bloodwork for a recent bought of terrible food poisoning. It would be so cool to be free of this rotten disease. Good luck to all. The structure of two basi...
by Squeakycat
Fri Dec 13, 2013 12:20 pm
Forum: General Discussion
Topic: Single Calcitriol Dose Beats Back EAE in Mice
Replies: 17
Views: 2499

Re: Single Calcitriol Dose Beats Back EAE in Mice

In any case, this research is incredibly interesting. I believe that MS is likely many different diseases which present similar symptoms which could explain why some therapies such as LDN, DMDs, diet, CCVSI, chemo and so on work for many but not all. Would also indicate why scientists have not foun...
by Squeakycat
Fri Dec 13, 2013 9:06 am
Forum: General Discussion
Topic: Single Calcitriol Dose Beats Back EAE in Mice
Replies: 17
Views: 2499

Re: Single Calcitriol Dose Beats Back EAE in Mice

Vitamin D3 is cheap. Maybe the research are working on a form of vitamin D which they can sell us for a lot of money. Professor Hayes has been studying the link between Vitamin D and MS for over 30 years. Calcitriol is a prescription medicine, but the dose needed for humans based on her mouse study...
by Squeakycat
Fri Dec 13, 2013 7:36 am
Forum: General Discussion
Topic: Single Calcitriol Dose Beats Back EAE in Mice
Replies: 17
Views: 2499

Re: Single Calcitriol Dose Beats Back EAE in Mice

I think most accept that vitamin D is important in treating MS. Why not buy the vitamin D3 over the counter. Why do the mice get better but the people do not? This is the key finding in the Hayes study: Over the counter vitamin D3 has to be converted to the bio-active form, calcitriol. Something in...
by Squeakycat
Thu Dec 12, 2013 10:04 pm
Forum: General Discussion
Topic: Single Calcitriol Dose Beats Back EAE in Mice
Replies: 17
Views: 2499

Re: Single Calcitriol Dose Beats Back EAE in Mice

“There are more than 100 compounds of proven efficacy in EAE, and we believe that it is pointless to add anymore to this list” -Sriram & Steiner Source: http://www.ncbi.nlm.nih.gov/pubmed/16315280 not to discount EAE, but no need to get too excited EAE is not MS and mice are not humans. I haven't r...
by Squeakycat
Thu Dec 12, 2013 9:13 pm
Forum: General Discussion
Topic: Single Calcitriol Dose Beats Back EAE in Mice
Replies: 17
Views: 2499

Re: Single Calcitriol Dose Beats Back EAE in Mice

Does anyone know of a human animal with MS that has tried a single dose of Calcitriol greater than say 10mcg? CureorBust? PN As far as I know, the highest studied dose was 2.5 mcg/d in Wingerchuk [/size] and an Iranian study which I can't put my hands on at the moment. To minimize hypercalcemia, hi...