Search found 411 matches

by Squeakycat
Sat Nov 16, 2013 2:13 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

Has anyone tried a megadose of calcitriol yet? If I am able to get the go ahead, I will do it. A controlled study would be great but none on my radar so far. Also, what can someone expect to feel when dosed so highly. Is the MTD the absolute limit? Thanks for all of the great info. No one yet, that...
by Squeakycat
Fri Nov 08, 2013 5:51 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: DrSclafani answers some questions
Replies: 8342
Views: 1657435

Re: DrSclafani answers some questions

Cece wrote:Squeakycat, do you have the full article? What do they mean by SCM stretching maneuver?
The full article.

http://www.biomedcentral.com/content/pd ... 13-162.pdf
by Squeakycat
Fri Nov 08, 2013 3:03 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: DrSclafani answers some questions
Replies: 8342
Views: 1657435

Re: DrSclafani answers some questions

And another new study which suggests a way to predict the outcome of venoplasty: Source URL: http://www.jvir.org/article/S1051-0443(13)01393-6/abstract DOI: 10.1016/j.jvir.2013.08.024 Journal Title: Journal of Vascular and Interventional Radiology Abstract URL: http://www.ncbi.nlm.nih.govhttp://www....
by Squeakycat
Fri Nov 08, 2013 2:31 pm
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: DrSclafani answers some questions
Replies: 8342
Views: 1657435

Re: DrSclafani answers some questions

Interesting new study [/b][/size] that shows a link between a set of venous abnormalities and the type of MS: No significant difference was found in the distribution of these miopragic veins with regard to MS duration. There was a strong association between the CCSVI scores and the complexity of jug...
by Squeakycat
Thu Nov 07, 2013 1:23 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

Hello, Wondering how the human male dose for calcitriol and d3 regimen can be calculated. 400ng for a mouse would be how much for 100kg man. My GP is interested in this study and is willing to let me try it. He just wants a figure before dosing me. Having a bit of a flare now and not a huge fan of ...
by Squeakycat
Thu Nov 07, 2013 1:18 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

Hello, Wondering how the human male dose for calcitriol and d3 regimen can be calculated. 400ng for a mouse would be how much for 100kg man. My GP is interested in this study and is willing to let me try it. He just wants a figure before dosing me. Having a bit of a flare now and not a huge fan of ...
by Squeakycat
Wed Oct 30, 2013 6:39 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

there is no question whatsoever in my mind that addressing deficiency would be beneficial, and that not doing so would be negligent. Jimmylegs, Agree COMPLETELY. When we win the lottery, we can fund the ultimate study that looks directly at counts for all the different immune cells implicated in MS...
by Squeakycat
Wed Oct 30, 2013 6:09 am
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

The zinc/MS question seems convoluted at best (at least in my mind at this time). NHE, Indeed! Getting rid of metal seems to help in a number of neurodegenerative diseases. There appears to be a very narrow Goldilocks range for most. Too little is bad. Too much is bad. But just right is therapeutic.
by Squeakycat
Tue Oct 29, 2013 6:58 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

I read it as: optimize zinc first, then test to determine if additional d3 or calcitriol are needed. since zinc corrects overexpression of TNF-alpha and IL-6 as above, AND zinc fosters proper renal hydroxylation of D3 to calcitriol as per the studies above, AND IF vit d3 status is positively correl...
by Squeakycat
Tue Oct 29, 2013 2:32 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

Good stuff. Zinc it is!

Along with calcitriol +D3.

Nothing here says that zinc alone will change status in MS, or do you read it that way?
by Squeakycat
Mon Oct 28, 2013 6:23 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

no drama, just clarifying and making distinctions between the context of the studies you're talking about, compared to the studies i'm talking about. i'm talking about the potential for zinc to correct that cellular failing. I don't go for approaches that bypass broken systems. I prefer to fix them...
by Squeakycat
Mon Oct 28, 2013 1:57 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

Jimmylegs, Peace. I didn't mean to come across as challenging you or showing a disdain for zinc. Really. The problem that Hayes protocol addresses is that cells are unable to convert 25(OH)D3 to calcitriol and calcitriol is the master, regulatory hormone of the adaptive immune system. What I was try...
by Squeakycat
Sun Oct 27, 2013 7:45 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

Squeaky...are you going to keep squeaking or try it??!! So far, it's next on my list if rituxan fails. I need to research it more though. It'd be nice if some guinea cat went before me. :P errrr. Do you have ms? I don't have MS, but I have offered to try up to 3X the dose to test safety. I have use...
by Squeakycat
Sun Oct 27, 2013 6:58 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419671/ "The synthesis of bioactive vitamin D requires hydroxylation at the 1α and 25 positions by cytochrome P450 enzymes in the kidney and liver, respectively. The mitochond...
by Squeakycat
Sun Oct 27, 2013 6:43 pm
Forum: Natural Approach
Topic: all things vitamin D
Replies: 1061
Views: 118609

Re: all things vitamin D

i have spent some time on that angle before. interesting interactions. Jimmylegs, How did I know if I said "Vitamin D," you would say "Zinc." :lol: But I think I can prove to you that this is not about zinc. 1. When Hayes gives her mice sufficient calcitriol to raise CSF levels, pro-inflammatory cy...