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Posting a link to two recently reported studies of estadiol and testosterone, under vitamin D because like calcitriol, the bioactive form of vitamin D, they are secosteroids and they interact. A complete guess, but I suspect that the benefits of both may well be linked to that interaction with calci...

Posting this here because estradiol and testosterone are, like vitamin D, secosteroids that interact. It may be that the benefits being found in recent studies are the result of this interaction with calcitriol, the bio-active form of vitamin D. (I don't know that. I'm just speculating that this may...

recall: Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III we limited our study population to 12257 participants The study provides important findings concerning POTENTIAL (emphasis added) metabolic intera...

Part of the issue in this discussion is the characterization of the vitamin D dose as high when at least in evolutionary terms and what the body sets as the upper limit, it is not high. I have been arguing that we should look at this issue in the calcitriol + D3 trial and have raised the issue with ...

i'll agree that d3 has had more than its fair share of the research attention, but that's about it. d3 will rise to some extent with supplementation, even when cofactor status is suboptimal. it's not an on-off switch. asserting that people only need to worry about co-factors if their d3 levels don'...

Ed has shown that D3 is the leading actor in the majority of pwMS. Co-factors are supporting actors in a minority of pwMS, we need to be aware of them if supplementing with natural D3 does not cause a rise in bloodlevels of D3. MarkW Were I king of MS diagnosis, I think I would make testing for mag...

This list is from an excellent review article on vitamin D and auto-immune diseases which looks at genetic and cellular basis for the link. Source URL: http://www.ncbi.nlm.nih.gov/pubmed/23359064 PMID: 23359064 DOI: http://dx.doi.org/10.1007/s12016-013-8361-3 Journal Title: Clinical reviews in aller...

I think we can all agree that calcium, magnesium, zinc and copper are co-factors of vitamin D and as such merit consideration. Given this, I would think it worthwhile to test whether there are deficiencies and whether correcting them changes clinical outcomes as a part of a trial of calcitriol + D3....

jimmylegs wrote:all right so for healthy controls probably low on mag and zinc, and the cal mag ratio is probably too high.

The actual numbers are 333 mg calcium carbonate, 133 mg magnesium oxide, and 5 mg zinc sulfate. There is also some magnesium stearate of an unspecified amount.

what are these rda levels of ca mg and cu, iima? if not using a zinc supplement, how many mgs of elemental zinc are you getting daily from diet? i'm surprised you're supplementing copper and not zinc. pretty counter-intuitive given how often a high copper zinc ratio is problematic, and how rarely t...

Good to see the research of the past is being used! Key points that impact this discussion. 1. The Vit D findings where low levels are common in PwMS and that increasing these levels changed the relapse rate are not conclusive that Vit D supplementing was an influencing factor, rather that it was a...

Were cost not an issue, I think we would all agree it makes sense to get tested for 25(OH)D levels as well as the main co-factors: calcium, zinc, magnesium and copper. certainly. and where cost of testing is an issue, patients considering high dose d3 still need to understand the importance of dail...

Testing for the main co-factors is a non starter on NHS. MarkW Do you know if B12 testing is standard with MS and covered by NHS? If it is, with some further study, it might be possible to make a case to not only allow, but to require co-factor testing in MS. With a fair wind in terms of financial ...

Hey squeaky, You must have found some studies since I first asked about calcitriol co factors. Links?? Are they all ckd sources?? No. I don't see what there is to find. 25OHD is not bioactive. It is just there to either be converted to calcitriol or degraded. Meanwhile, calcitriol is interacting wi...

Here is a link to a new Vitamin D study, which measured the affects of Vitamin D on endothelial health in a group of people who were vitamin D deficient with chronic kidney disease. What interested me is that they used hard science ways to test endothelial function before and after supplementing wi...